Results 81 to 90 of about 11,119 (186)
Restricting activation‐induced cytidine deaminase tumorigenic activity in B lymphocytes
Immunology, 2009 SummaryDNA breaks play an essential role in germinal centre B cells as intermediates to immunoglobulin class switching, a recombination process initiated by activation‐induced cytidine deaminase (AID). Immunoglobulin gene hypermutation is likewise catalysed by AID but is believed to occur via single‐strand DNA breaks.
Rafael, Casellas +3 more
openaire +3 more sources
Sex differences in the clinical presentation of patients with newly diagnosed multiple myeloma
Cancer, Volume 132, Issue 2, 15 January 2026.Abstract Introduction Standardized incidence rates of multiple myeloma (MM) are higher among males than females, suggesting that male sex is an important risk factor for MM, which may affect disease etiology, pathogenesis, and clinical presentation. Methods The association of sex with the prevalence of clinical features and chromosomal abnormalities ...
Krystle L. Ong +6 more
wiley +1 more source
Activation-induced cytidine deaminase splicing patterns in chronic lymphocytic leukemia
Blood Cells, Molecules, and Diseases, 2010 Activation-induced cytidine deaminase (AID) is critically implicated in somatic hypermutation (SHM) and class switch recombination (CSR). AID is expressed as a native transcript and as several splice variants, with as yet undefined roles. Chronic lymphocytic leukemia (CLL) leukemic B cells have also been shown to express AID transcripts, especially in ...
Foteini, Marantidou +11 more
openaire +3 more sources
DNA methyltransferase inhibitors in hematological malignancies and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger +3 more
wiley +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang +14 more
wiley +1 more source
A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts
European Journal of Immunology, Volume 56, Issue 1, January 2026.Picture‐book compartmentalization makes tonsillar tissue an ideal model to study spatial immunology. Using single‐molecule imaging (SMI) of whole‐tissue sections, we showcase many an alternative view on tissue composition and architecture that these data and concomitant analyses provide—at the level of single cells, cellular neighborhoods, and ...
Helena L. Crowell +11 more
wiley +1 more source
Activation-induced cytidine deaminase (AID): single activity – pleiotropic effect [PDF]
BioTechnologia, 2014 Activation-induced cytidine deaminase (AID) plays an essential role in the generation of a highly competent repertoire<br /> of antibodies by participating in class switch recombination (CSR) and somatic hypermutation (SHM). After<br /> B cell stimulation by antigens, AID initiates SHM and CSR by deamination of cytidine to uridine in the ...
Lucyna Budzko +2 more
openaire +1 more source
Navigating the evolving management of smoldering multiple myeloma
HemaSphere, Volume 10, Issue 1, January 2026.Abstract Smoldering multiple myeloma (SMM) represents an intermediate clinical stage between monoclonal gammopathy of undetermined significance (MGUS) and symptomatic multiple myeloma (MM). SMM carries a highly variable risk of progression to MM, requiring individualized risk stratification to guide management.
M. Bakri Hammami +6 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 1, Page 24-39, January 2026.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
Gene conversion-like events in the diversification of human rearranged IGHV3-23*01 gene sequences
Frontiers in Immunology, 2012 Gene conversion (GCV) as a mechanism of immunoglobulin diversification is well established in a few species. However, definitive evidence of GCV-like events in human immunoglobulin genes is scarce. GCV is mediated by activation-induced cytidine deaminase
Bhargavi eDuvvuri, Gillian E Wu
doaj +1 more source