Results 11 to 20 of about 7,192,603 (344)
FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab
Frontiers in Immunology, 2023 IntroductionTargeting costimulatory receptors of the tumor necrosis factor receptor (TNFR) superfamily with agonistic antibodies is a promising approach in cancer immuno therapy.
Judith Leitner +4 more
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Scalable carbon dioxide electroreduction coupled to carbonylation chemistry
Nature Communications, 2017 Electroreduction of CO2 to CO is a potential valorisation pathway of carbon dioxide for fine chemicals production. Here, the authors show a user-friendly device that couples CO2 electroreduction with carbonylation chemistry for up to gram scale synthesis
Mikkel T. Jensen +8 more
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Cell Reports, 2018 Summary: B cell responses are regulated by antigen acquisition, processing, and presentation to helper T cells. These functions are thought to depend on contractile activity of non-muscle myosin IIa.
Robbert Hoogeboom +6 more
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Cooperative redox activation for carbon dioxide conversion
Nature Communications, 2016 While CO2 can be converted to CO for further reactivity, typically this involves the generation of large amounts of waste. Here the authors report the conversion of CO2to CO, with the siloxane by-product being further used in a carbonylative Hiyama ...
Zhong Lian +4 more
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Cells, 2021 LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments.
Juan José Saez +5 more
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Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse
Nature Communications, 2019 The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti +10 more
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Not All Immune Checkpoints Are Created Equal
Frontiers in Immunology, 2018 Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory surface receptors that are considered to have potential as targets in ...
Annika De Sousa Linhares +3 more
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Transcriptional activators and activation mechanisms [PDF]
Protein & Cell, 2007 Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.
openaire +2 more sources
Nature Communications, 2022 Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Qu Chen +4 more
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Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility
EMBO Molecular Medicine, 2018 Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter +9 more
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