Results 21 to 30 of about 7,259,671 (332)
ACE2 ACTIVATION PROMOTES ANTITHROMBOTIC ACTIVITY
The FASEB Journal, 2009 Hyperactivity of the axis ACE/AngII/AT1R of the renin‐angiotensin system is associated with occurrence of acute thrombotic event. Recently a novel concept of a counterrugulatory axis, ACE2/Ang‐(1‐7)/Mas, has emerged. We hypothesized that ACE2 would be protective against thrombosis.
Rodrigo A, Fraga-Silva +10 more
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Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse
Nature Communications, 2019 The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti +10 more
doaj +1 more source
Not All Immune Checkpoints Are Created Equal
Frontiers in Immunology, 2018 Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory surface receptors that are considered to have potential as targets in ...
Annika De Sousa Linhares +3 more
doaj +1 more source
Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]
, 2017 Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette +11 more
core +2 more sources
Transcriptional activators and activation mechanisms [PDF]
Protein & Cell, 2007 Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.
openaire +2 more sources
Septentrio Conference Series, 2020 First year architecture students are introduced to the library by taking part in an “Escape Room” activity in the KTH library. The aim of this initiative is to introduce the students to the library space and the library's resources in an interactive and playful way and to enable them to learn and reflect upon their learning within the frame of an ...
Lenita Brodin Berggren, Ika Jorum
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Cells, 2021 LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments.
Juan José Saez +5 more
doaj +1 more source
Diffusion of volatile organic chemicals in porous media. 2. alcohol/templated porous carbon systems [PDF]
, 2006 The aim of the present report was to measure the diffusion coefficients, modes of transport, and activation energies of some alcohols into templated porous carbons.
Sakintuna, Billur +2 more
core +1 more source
Active colloidal molecules in activity gradients [PDF]
Physical Review E, 2022 We consider a rigid assembly of two active Brownian particles, forming an active colloidal dimer, in a gradient of activity. We show analytically that depending on the relative orientation of the two particles the active dimer accumulates in regions of either high or low activity, corresponding to, respectively, chemotaxis and antichemotaxis.
Hidde D. Vuijk +4 more
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Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility
EMBO Molecular Medicine, 2018 Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter +9 more
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