Results 21 to 30 of about 7,192,603 (344)

Interrogating ligand-receptor interactions using highly sensitive cellular biosensors

Nature Communications, 2023
Interactions of membrane-resident proteins are important targets for therapeutic interventions but most methods to study them are either costly, laborious or fail to reflect the physiologic interaction of membrane resident proteins in trans.
Maximilian A. Funk, Judith Leitner, Marlene C. Gerner, Jasmin M. Hammerler, Benjamin Salzer, Manfred Lehner, Claire Battin, Simon Gumpelmair, Karin Stiasny, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +10 more
doaj   +1 more source

Dinuclear PhosphoiminoBINOL-Pd Container for Malononitrile: Catalytic Asymmetric Double Mannich Reaction for Chiral 1,3-Diamine Synthesis

Scientific Reports, 2018
A phosphoiminoBINOL ligand was designed to form a dinuclear metal complex that could hold a malononitrile molecule. The dinuclear bis(phosphoimino)binaphthoxy-Pd2(OAc)2 complex catalyzed a double Mannich reaction of N-Boc-imines with malononitrile to ...
Takayoshi Arai, Katsuya Sato, Ayu Nakamura, Hiroki Makino, Hyuma Masu   +4 more
doaj   +1 more source

A Mouse Model to Study the Pathogenesis of γ-herpesviral Infections in Germinal Center B Cells

Cells, 2023
CD30-positive germinal center (GC)-derived B cell lymphomas are frequently linked to Epstein–Barr Virus (EBV) infection. However, a suitable animal model for the investigation of the interplay between γ-herpesvirus and host cells in B cell pathogenesis ...
Ursula Rambold, Stefanie Sperling, Zakir Chew, Yan Wang, Beatrix Steer, Krisztina Zeller, Lothar J. Strobl, Ursula Zimber-Strobl, Heiko Adler   +8 more
doaj   +1 more source

B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments

eLife, 2019
Antibody production depends on B cell internalization and presentation of antigens to helper T cells. To acquire antigens displayed by antigen-presenting cells, B cells form immune synapses and extract antigens by the mechanical activity of the acto ...
Sophie I Roper, Laabiah Wasim, Dessislava Malinova, Michael Way, Susan Cox, Pavel Tolar   +5 more
doaj   +1 more source

A Highly Sensitive Cell-Based TLR Reporter Platform for the Specific Detection of Bacterial TLR Ligands

Frontiers in Immunology, 2022
Toll-like receptors (TLRs) are primary pattern recognition receptors (PRRs), which recognize conserved microbial components. They play important roles in innate immunity but also in the initiation of adaptive immune responses.
Katharina Radakovics, Claire Battin, Judith Leitner, Sabine Geiselhart, Wolfgang Paster, Johannes Stöckl, Karin Hoffmann-Sommergruber, Peter Steinberger   +7 more
doaj   +1 more source

The Impact of Knowledge About Business Model Canvas (BMC) on Entrepreneurial Interest of Young Generation in Jabodetabek

Indonesian Journal of Business and Entrepreneurship
This research aims to investigate the influence of Business Model Canvas (BMC) knowledge on entrepreneurial knowledge among young generations in the Jabodetabek region.
Nur Hendrasto, Fauziah Chairiyati, Abdullah Haidar, Evania Herindar, Hafiz Mudassir Rehman   +4 more
doaj   +1 more source

New Directions in Transition Metal Catalyzed Carbonylation Chemistry

CHIMIA, 2018
Carbon monoxide (CO) represents an important C1-building block for the construction of some of the most fundamental chemical functionalities carrying a carbon–oxygen double bond.
Dennis U. Nielsen, Karoline T. Neumann, Troels Skrydstrup   +2 more
doaj   +1 more source

The Leech Nervous System: A Valuable Model to Study the Microglia Involvement in Regenerative Processes

Clinical and Developmental Immunology, 2013
Microglia are intrinsic components of the central nervous system (CNS). During pathologies in mammals, inflammatory processes implicate the resident microglia and the infiltration of blood cells including macrophages.
Françoise Le Marrec-Croq, Francesco Drago, Jacopo Vizioli, Pierre-Eric Sautière, Christophe Lefebvre   +4 more
doaj   +1 more source

First Results on Moss Biomonitoring of Trace Elements in the Central Part of Georgia, Caucasus

Atmosphere, 2021
The moss biomonitoring technique was used for assessment of air pollution in the central part of Georgia, Caucasus, in the framework of the UNECE ICP Vegetation.
Omari Chaligava, Igor Nikolaev, Khetag Khetagurov, Yulia Lavrinenko, Anvar Bazaev, Marina Frontasyeva, Konstantin Vergel, Dmitry Grozdov   +7 more
doaj   +1 more source

Actively Seeking Activating Sequences [PDF]

Cell, 2004
I thank R. Brent, I. Cartwright, L. Keegan, Z. Liu, M. Ptashne, and M. Xu for comments. I apologize that the page limit did not permit citation of all relevant work. This work was supported in part by the AHA and the NSF.
openaire   +2 more sources