Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Enhancement of license plate recognition performance using Xception with Mish activation function. [PDF]
Multimed Tools Appl, 2023 Pattanaik A, Balabantaray RC.
europepmc +1 more source
Activating FcγR function depends on endosomal-signaling platforms [PDF]
, 2023 Samira Benadda +8 more
openalex +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Author Correction: Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus. [PDF]
BMC Biol, 2023 Lee SH +10 more
europepmc +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A novel scaled-gamma-tanh (SGT) activation function in 3D CNN applied for MRI classification. [PDF]
Sci Rep, 2022 Khagi B, Kwon GR.
europepmc +1 more source
Impaired benthic macrofauna function 4 years after sediment capping with activated carbon in the Grenland fjords, Norway [PDF]
, 2020 Caroline Raymond +4 more
openalex +1 more source