Results 1 to 10 of about 3,963,692 (395)

Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. [PDF]

PLoS ONE, 2015
Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity.
Marquitta J White, Nuri M Kodaman, Reed H Harder, Folkert W Asselbergs, Douglas E Vaughan, Nancy J Brown, Jason H Moore, Scott M Williams   +7 more
doaj   +3 more sources

Mouse genetics: Catalogue and scissors [PDF]

BMB Reports, 2012
Phenotypic analysis of gene-specific knockout (KO) mice hasrevolutionized our understanding of in vivo gene functions. Asthe use of mouse embryonic stem (ES) cells is inevitable forconventional gene targeting, the generation of knockout miceremains a ...
Han-Woong Lee
doaj   +2 more sources

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

Nature Reviews Genetics, 2010
Sohail Malik, Robert G Roeder
exaly   +2 more sources

Genetics of Somatic Mammalian Cells: Demonstration of a Human Esterase Activator Gene Linked to the AdeB Gene

Proceedings of the National Academy of Sciences of the United States of America, 1972
Fa‐Ten Kao, Theodore T. Puck
openalex   +3 more sources

Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance [PDF]

, 2013
Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson, Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of ...
Atkinson, Nigel S., Ghezzi, Alfredo, Krishnan, Harish R., Lew, Linda, Ong, Darryl S., Prado III, Francisco J.   +5 more
core   +15 more sources

CRISPR-Cas9 Technology for the Creation of Biological Avatars Capable of Modeling and Treating Pathologies: From Discovery to the Latest Improvements

Cells, 2022
This is a spectacular moment for genetics to evolve in genome editing, which encompasses the precise alteration of the cellular DNA sequences within various species. One of the most fascinating genome-editing technologies currently available is Clustered
Ali Nasrallah, Eric Sulpice, Farah Kobaisi, Xavier Gidrol, Walid Rachidi   +4 more
doaj   +1 more source

Targeted mutagenesis in the malaria mosquito using TALE nucleases. [PDF]

PLoS ONE, 2013
Anopheles gambiae, the main mosquito vector of human malaria, is a challenging organism to manipulate genetically. As a consequence, reverse genetics studies in this disease vector have been largely limited to RNA interference experiments.
Andrea L Smidler, Olivier Terenzi, Julien Soichot, Elena A Levashina, Eric Marois   +4 more
doaj   +1 more source

Recent advances in genetically modified large-animal models of human diseases

BIO Integration, 2022
Large-animal models show greater advantages than rodents in recapitulating human genetic diseases, primarily because of their higher similarity to humans in terms of anatomy, physiology and genetics.
Jing Zhang, Xiaoyue Sun, Chunwei Cao
doaj   +1 more source

The dawn of active genetics [PDF]

BioEssays, 2015
On December 18, 2014, a yellow female fly quietly emerged from her pupal case. What made her unique was that she had only one parent carrying a mutant allele of this classic recessive locus.
Valentino M, Gantz, Ethan, Bier
openaire   +2 more sources

KATP channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapies

Frontiers in Endocrinology, 2023
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh, Assmaa ElSheikh, Show-Ling Shyng   +2 more
doaj   +1 more source