Results 1 to 10 of about 3,709,674 (359)

Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. [PDF]

PLoS ONE, 2015
Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity.
Marquitta J White, Nuri M Kodaman, Reed H Harder, Folkert W Asselbergs, Douglas E Vaughan, Nancy J Brown, Jason H Moore, Scott M Williams   +7 more
doaj   +3 more sources

Mouse genetics: Catalogue and scissors [PDF]

BMB Reports, 2012
Phenotypic analysis of gene-specific knockout (KO) mice hasrevolutionized our understanding of in vivo gene functions. Asthe use of mouse embryonic stem (ES) cells is inevitable forconventional gene targeting, the generation of knockout miceremains a ...
Han-Woong Lee
doaj   +2 more sources

Genetics of somatic mammalian cells: demonstration of a human esterase activator gene linked to the adeB gene. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1972
F. Kao, T. Puck
semanticscholar   +2 more sources

MPF Regulates Oocyte and Embryo Development During Parthenogenesis Induction in Silkworm, Bombyx mori [PDF]

Insects
In most species, oocytes are arrested at the prophase or metaphase of meiosis I and require sperm-derived or external stimuli to resume meiosis. Maturation-promoting factor (MPF) is an oocyte maturation factor composing the catalytic subunit Cdc2 and the
Chenkai Ma, Fang Xu, Chengjie Hu, Chunguang Cui, Xin Du, Jine Chen, Linbao Zhu, Shaofang Yu, Xingjian He, Wei Yu, Yongqiang Wang, Xia Xu   +11 more
doaj   +2 more sources

Unraveling the impact of blood RANKL and OPG levels on Alzheimer's disease: Independent of bone mineral density and inflammation [PDF]

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Observational studies have revealed a close relationship between reduced bone mineral density (BMD) and Alzheimer's disease (AD) risk. The receptor activator of nuclear factor kappa‐B ligand (RANKL) and osteoprotegerin (OPG) system, pivotal ...
Xingzhi Guo, Wenzhi Shi, Juanjuan Lu, Peng Tang, Rui Li   +4 more
doaj   +2 more sources

CRISPR-Cas9 Technology for the Creation of Biological Avatars Capable of Modeling and Treating Pathologies: From Discovery to the Latest Improvements

Cells, 2022
This is a spectacular moment for genetics to evolve in genome editing, which encompasses the precise alteration of the cellular DNA sequences within various species. One of the most fascinating genome-editing technologies currently available is Clustered
Ali Nasrallah, Eric Sulpice, Farah Kobaisi, Xavier Gidrol, Walid Rachidi   +4 more
doaj   +1 more source

Targeted mutagenesis in the malaria mosquito using TALE nucleases. [PDF]

PLoS ONE, 2013
Anopheles gambiae, the main mosquito vector of human malaria, is a challenging organism to manipulate genetically. As a consequence, reverse genetics studies in this disease vector have been largely limited to RNA interference experiments.
Andrea L Smidler, Olivier Terenzi, Julien Soichot, Elena A Levashina, Eric Marois   +4 more
doaj   +1 more source

Recent advances in genetically modified large-animal models of human diseases

BIO Integration, 2022
Large-animal models show greater advantages than rodents in recapitulating human genetic diseases, primarily because of their higher similarity to humans in terms of anatomy, physiology and genetics.
Jing Zhang, Xiaoyue Sun, Chunwei Cao
doaj   +1 more source

PRMT5 Cooperates with pICln to Function as a Master Epigenetic Activator of DNA Double-Strand Break Repair Genes

iScience, 2020
Summary: DNA double-strand break (DSB) repair is critical for cell survival and genome integrity. Upon recognition of DSBs, repair proteins are transiently upregulated to facilitate repair through homologous recombination (HR) or non-homologous end ...
Jake L. Owens, Elena Beketova, Sheng Liu, Samantha L. Tinsley, Andrew M. Asberry, Xuehong Deng, Jiaoti Huang, Chenglong Li, Jun Wan, Chang-Deng Hu   +9 more
doaj   +1 more source

KATP channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapies

Frontiers in Endocrinology, 2023
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh, Assmaa ElSheikh, Show-Ling Shyng   +2 more
doaj   +1 more source