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The dawn of active genetics [PDF]
BioEssays, 2015 On December 18, 2014, a yellow female fly quietly emerged from her pupal case. What made her unique was that she had only one parent carrying a mutant allele of this classic recessive locus. Then, one generation later, after mating with a wild‐type male, all her offspring displayed the same recessive yellow phenotype.
Valentino M. Gantz, Ethan Bier
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Regulation of transcription elongation in response to osmostress [PDF]
, 1967 Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell fitness when yeast cells are exposed
Begley, Victoria Sarah +7 more
core +11 more sources
Genetic Constructs for the Control of Astrocytes’ Activity [PDF]
Cells, 2021 In the current review, we aim to discuss the principles and the perspectives of using the genetic constructs based on AAV vectors to regulate astrocytes’ activity. Practical applications of optogenetic approaches utilizing different genetically encoded opsins to control astroglia activity were evaluated.
O. L. Vlasova +5 more
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The Genetic Activity Profile Database [PDF]
Environmental Health Perspectives, 1991 A graphic approach termed a Genetic Activity Profile (GAP) has been developed to display a matrix of data on the genetic and related effects of selected chemical agents. The profiles provide a visual overview of the quantitative (doses) and qualitative (test results) data for each chemical.
Michael D. Waters +3 more
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Genetics of plasma paroxonase activity [PDF]
Journal of Medical Genetics, 1982 Complex segregation analysis of plasma paroxonase activity gives evidence for a major locus with incomplete dominance (d = 0·70) causing high activity plus a background of multifactorial inheritance (heritability = 0·09).
D A P Evans, L Iselius, J R Playfer
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Genome-Wide Multiple Sclerosis Association Data and Coagulation [PDF]
, 2019 The emerging concept of a crosstalk between hemostasis, inflammation, and immune system prompt recent works on coagulation cascade in multiple sclerosis (MS).
Arianna Fornasiero +10 more
core +2 more sources
Genetic control of active neural circuits [PDF]
Frontiers in Molecular Neuroscience, 2009 The use of molecular tools to study the neurobiology of complex behaviors has been hampered by an inability to target the desired changes to relevant groups of neurons. Specific memories and specific sensory representations are sparsely encoded by a small fraction of neurons embedded in a sea of morphologically and functionally similar cells.
Leon Reijmers +3 more
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Distinct regions of the Swi5 and Ace2 transcription factors are required for specific gene activation [PDF]
, 1999 Swi5 and Ace2 are cell cycle-regulated transcription factors that activate expression of early G1-specific genes in Saccharomyces cerevisiae. Swi5 and Ace2 have zinc finger DNA-binding domains that are highly conserved, and the two proteins bind to the ...
McBride, Helen J. +2 more
core +2 more sources
Genetic Dissection of Antibiotic Adjuvant Activity
mBio, 2022 One strategy to confront the antibiotic resistance crisis is through the development of adjuvant compounds that increase the efficacy of established drugs. A key step in the development of a natural product adjuvant as a drug is identifying the resistance process it undermines to enhance antibiotic activity.
J. Bailey +6 more
openaire +3 more sources
Scaling and regeneration of self-organized patterns [PDF]
, 2015 Biological patterns generated during development and regeneration often scale with organism size. Some organisms, e.g., flatworms, can regenerate a rescaled body plan from tissue fragments of varying sizes.
Amigo, Manuel Beirán +5 more
core +2 more sources