Results 1 to 10 of about 211,068 (353)

Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. [PDF]

open access: goldPLoS ONE, 2015
Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity.
Marquitta J White   +7 more
doaj   +3 more sources

MPF Regulates Oocyte and Embryo Development During Parthenogenesis Induction in Silkworm, Bombyx mori [PDF]

open access: yesInsects
In most species, oocytes are arrested at the prophase or metaphase of meiosis I and require sperm-derived or external stimuli to resume meiosis. Maturation-promoting factor (MPF) is an oocyte maturation factor composing the catalytic subunit Cdc2 and the
Chenkai Ma   +11 more
doaj   +2 more sources

Unraveling the impact of blood RANKL and OPG levels on Alzheimer's disease: Independent of bone mineral density and inflammation [PDF]

open access: yesAlzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Observational studies have revealed a close relationship between reduced bone mineral density (BMD) and Alzheimer's disease (AD) risk. The receptor activator of nuclear factor kappa‐B ligand (RANKL) and osteoprotegerin (OPG) system, pivotal ...
Xingzhi Guo   +4 more
doaj   +2 more sources

Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance [PDF]

open access: yes, 2013
Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson, Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of ...
Atkinson, Nigel S.   +5 more
core   +19 more sources

CRISPR-Cas9 Technology for the Creation of Biological Avatars Capable of Modeling and Treating Pathologies: From Discovery to the Latest Improvements

open access: yesCells, 2022
This is a spectacular moment for genetics to evolve in genome editing, which encompasses the precise alteration of the cellular DNA sequences within various species. One of the most fascinating genome-editing technologies currently available is Clustered
Ali Nasrallah   +4 more
doaj   +1 more source

The dawn of active genetics [PDF]

open access: yesBioEssays, 2015
On December 18, 2014, a yellow female fly quietly emerged from her pupal case. What made her unique was that she had only one parent carrying a mutant allele of this classic recessive locus. Then, one generation later, after mating with a wild‐type male, all her offspring displayed the same recessive yellow phenotype.
Valentino M. Gantz, Ethan Bier
openaire   +3 more sources

Targeted mutagenesis in the malaria mosquito using TALE nucleases. [PDF]

open access: yesPLoS ONE, 2013
Anopheles gambiae, the main mosquito vector of human malaria, is a challenging organism to manipulate genetically. As a consequence, reverse genetics studies in this disease vector have been largely limited to RNA interference experiments.
Andrea L Smidler   +4 more
doaj   +1 more source

Genetic Constructs for the Control of Astrocytes’ Activity [PDF]

open access: yesCells, 2021
In the current review, we aim to discuss the principles and the perspectives of using the genetic constructs based on AAV vectors to regulate astrocytes’ activity. Practical applications of optogenetic approaches utilizing different genetically encoded opsins to control astroglia activity were evaluated.
O. L. Vlasova   +5 more
openaire   +4 more sources

Recent advances in genetically modified large-animal models of human diseases

open access: yesBIO Integration, 2022
Large-animal models show greater advantages than rodents in recapitulating human genetic diseases, primarily because of their higher similarity to humans in terms of anatomy, physiology and genetics.
Jing Zhang, Xiaoyue Sun, Chunwei Cao
doaj   +1 more source

KATP channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapies

open access: yesFrontiers in Endocrinology, 2023
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh   +2 more
doaj   +1 more source

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