Results 11 to 20 of about 3,917,874 (426)
Genetics of Somatic Mammalian Cells: Demonstration of a Human Esterase Activator Gene Linked to the AdeB Gene [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1972 Prototrophic hybrids formed from an adenine-requiring Chinese hamster cell and human fibroblasts uniformly display new esterase activity that differs from that of either parental cell in electrophoretic mobility and substrate specificity.
Fa‐Ten Kao, Theodore T. Puck
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Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. [PDF]
PLoS ONE, 2015 Plasminogen activator inhibitor 1 (PAI-1), a major modulator of the fibrinolytic system, is an important factor in cardiovascular disease (CVD) susceptibility and severity.
Marquitta J White +7 more
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Mouse genetics: Catalogue and scissors [PDF]
BMB Reports, 2012 Phenotypic analysis of gene-specific knockout (KO) mice hasrevolutionized our understanding of in vivo gene functions. Asthe use of mouse embryonic stem (ES) cells is inevitable forconventional gene targeting, the generation of knockout miceremains a ...
Han-Woong Lee
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MPF Regulates Oocyte and Embryo Development During Parthenogenesis Induction in Silkworm, <i>Bombyx mori</i>. [PDF]
InsectsIn most species, oocytes are arrested at the prophase or metaphase of meiosis I and require sperm-derived or external stimuli to resume meiosis. Maturation-promoting factor (MPF) is an oocyte maturation factor composing the catalytic subunit Cdc2 and the
Ma C +11 more
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Unraveling the impact of blood RANKL and OPG levels on Alzheimer's disease: Independent of bone mineral density and inflammation. [PDF]
Alzheimers Dement (N Y)INTRODUCTION Observational studies have revealed a close relationship between reduced bone mineral density (BMD) and Alzheimer's disease (AD) risk. The receptor activator of nuclear factor kappa‐B ligand (RANKL) and osteoprotegerin (OPG) system, pivotal ...
Guo X, Shi W, Lu J, Tang P, Li R.
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Cells, 2022 This is a spectacular moment for genetics to evolve in genome editing, which encompasses the precise alteration of the cellular DNA sequences within various species. One of the most fascinating genome-editing technologies currently available is Clustered
Ali Nasrallah +4 more
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Active information requirements for fixation on the Wright-Fisher model of population genetics [PDF]
BIO-Complexity 2020(4):1-6, 2021 In the context of population genetics, active information can be extended to measure the change of information of a given event (e.g., fixation of an allele) from a neutral model in which only genetic drift is taken into account to a non-neutral model that includes other sources of frequency variation (e.g., selection and mutation).
arxiv +1 more source
Targeted mutagenesis in the malaria mosquito using TALE nucleases. [PDF]
PLoS ONE, 2013 Anopheles gambiae, the main mosquito vector of human malaria, is a challenging organism to manipulate genetically. As a consequence, reverse genetics studies in this disease vector have been largely limited to RNA interference experiments.
Andrea L Smidler +4 more
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Recent advances in genetically modified large-animal models of human diseases
BIO Integration, 2022 Large-animal models show greater advantages than rodents in recapitulating human genetic diseases, primarily because of their higher similarity to humans in terms of anatomy, physiology and genetics.
Jing Zhang, Xiaoyue Sun, Chunwei Cao
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Frontiers in Endocrinology, 2023 Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh +2 more
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