Results 11 to 20 of about 260,779 (356)
The dawn of active genetics [PDF]
BioEssays, 2015 On December 18, 2014, a yellow female fly quietly emerged from her pupal case. What made her unique was that she had only one parent carrying a mutant allele of this classic recessive locus. Then, one generation later, after mating with a wild‐type male, all her offspring displayed the same recessive yellow phenotype.
Valentino M. Gantz, Ethan Bier
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Genetic Constructs for the Control of Astrocytes’ Activity [PDF]
Cells, 2021 In the current review, we aim to discuss the principles and the perspectives of using the genetic constructs based on AAV vectors to regulate astrocytes’ activity. Practical applications of optogenetic approaches utilizing different genetically encoded opsins to control astroglia activity were evaluated.
O. L. Vlasova +5 more
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The Genetic Activity Profile Database [PDF]
Environmental Health Perspectives, 1991 A graphic approach termed a Genetic Activity Profile (GAP) has been developed to display a matrix of data on the genetic and related effects of selected chemical agents. The profiles provide a visual overview of the quantitative (doses) and qualitative (test results) data for each chemical.
Michael D. Waters +3 more
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Genetics of plasma paroxonase activity [PDF]
Journal of Medical Genetics, 1982 Complex segregation analysis of plasma paroxonase activity gives evidence for a major locus with incomplete dominance (d = 0·70) causing high activity plus a background of multifactorial inheritance (heritability = 0·09).
D A P Evans, L Iselius, J R Playfer
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iScience, 2018 Summary: TUC338 is an ultraconserved long non-coding RNA that contributes to transformed cell growth in hepatocellular carcinoma (HCC). Genomic regions of TUC338 occupancy were enriched in unique or known binding motifs homologous to the tumor ...
Hui-Ju Wen +5 more
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Genetic control of active neural circuits [PDF]
Frontiers in Molecular Neuroscience, 2009 The use of molecular tools to study the neurobiology of complex behaviors has been hampered by an inability to target the desired changes to relevant groups of neurons. Specific memories and specific sensory representations are sparsely encoded by a small fraction of neurons embedded in a sea of morphologically and functionally similar cells.
Leon Reijmers +3 more
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Identification and characterization of a Mef2 transcriptional activator in schistosome parasites. [PDF]
PLoS Neglected Tropical Diseases, 2012 Myocyte enhancer factor 2 protein (Mef2) is an evolutionarily conserved activator of transcription that is critical to induce and control complex processes in myogenesis and neurogenesis in vertebrates and insects, and osteogenesis in vertebrates.
John N Milligan, Emmitt R Jolly
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EBioMedicine, 2023 Summary: Background: Identifying new drug targets for inflammatory bowel disease (IBD) is urgently needed. The proteome is a major source of therapeutic targets.
Jie Chen +11 more
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The Overlapping and Distinct Roles of HAM Family Genes in Arabidopsis Shoot Meristems
Frontiers in Plant Science, 2020 In Arabidopsis shoot apical meristems (SAMs), a well-characterized regulatory loop between WUSCHEL (WUS) and CLAVATA3 (CLV3) maintains stem cell homeostasis by regulating the balance between cell proliferation and cell differentiation.
Han Han +13 more
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Sexual Dimorphism in Osteoclasts
Cells, 2020 Osteoclasts are the principal mediators of bone resorption. They form through the fusion of mononuclear precursor cells under the principal influence of the cytokines macrophage colony stimulating factor (M-CSF, aka CSF-1) and receptor activator of NF-κB
Joseph Lorenzo
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