Results 81 to 90 of about 222,051 (290)

Targeting Clostridium difficile Surface Components to Develop Immunotherapeutic Strategies Against Clostridium difficile Infection

Frontiers in Microbiology, 2018
New therapies are needed to prevent and treat Clostridium difficile infection and to limit the rise in antibiotic resistance. Besides toxins, several surface components have been characterized as colonization factors and have been shown as immunogenic ...
Séverine Péchiné, Jean F. Bruxelle, Claire Janoir, Anne Collignon   +3 more
doaj   +1 more source

Structural insights and biomedical potential of IgNAR scaffolds from sharks [PDF]

, 2014
Peer reviewedPublisher ...
Barelle, Caroline, Empting, Martin, Grzeschik, Julius, Kolmar, Harald, Könning, Doreen, Zielonka, Stefan   +5 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Active and passive immunizations with HtsA, a streptococcal heme transporter protein, protect mice from subcutaneous group A Streptococcus infection

Journal of Microbiology, Immunology and Infection, 2020
Background/Purpose: HtsA (Streptococcus heme transporter A) is the lipoprotein component of the streptococcal heme ABC transporter (HtsABC). The aim of this study is to investigate whether the HtsA protein has immunoprotective effect against group A ...
Yingli Song, XiaoLan Zhang, Minghui Cai, Chunmei Lv, Yuan Zhao, Deqin Wei, Hui Zhu   +6 more
doaj   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Guiding the security protection of critical information infrastructure with scientific network security concept

物联网学报, 2019
In the current increasingly competitive international cyberspace security game,critical information infrastructure is facing a severe security situation.From the view of scientific principle,the essence of network security risk is the limitation of ...
Yangzhao LI, Changxiang SHEN, Nan TIAN
doaj  

The natural human adaptive IgG-specific immune response is skewed towards non-protective tail domains of DNABII proteins

Frontiers in Immunology
Biofilm-mediated infections are highly recalcitrant to antibiotics and host immune system clearance. The matrix that envelopes biofilm-resident bacteria is stabilized by extracellular DNA as well as integrated ubiquitous bacterial DNABII proteins that ...
Kathryn Q. Wilbanks, Jaime D. Rhodes, Steven D. Goodman, Steven D. Goodman, Sanjay Sethi, Sanjay Sethi, Timothy F. Murphy, Lauren O. Bakaletz, Lauren O. Bakaletz   +8 more
doaj   +1 more source

Active immunization trial in Aβ42-injected P301L tau transgenic mice

Neurobiology of Disease, 2006
Amyloid β-peptide (Aβ) containing plaques and neurofibrillary tangles (NFT) are the two major histopathological hallmarks of Alzheimer's disease (AD). According to the amyloid cascade hypothesis, deposition of Aβ is an initial and essential step in the ...
Luka Kulic, Pascal Kurosinski, Feng Chen, Jay Tracy, M. Hasan Mohajeri, Hong Li, Roger M. Nitsch, Jürgen Götz   +7 more
doaj   +1 more source

New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]

, 2014
There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P., Stavenhagen, Jeffrey B., Teeling, Jessica L.   +2 more
core   +3 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that preces the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source