Results 71 to 80 of about 2,358,768 (289)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The condition number for circulant networks [PDF]
, 2013 In this paper we prove that it is possible to use techniques specific to electromagnetic field synthesis in the study of some electrical circuits. The definition of a circulant network will be presented.
De Mey, Gilbert, Micu, Dan
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Phytic acid modified polycaprolactone electrospun matrix for active nerve regeneration
Results in ChemistryPhysicochemical modification of biomaterials has enormous potential for enhanced functionality and applications. Phytic acid (PA) is a sustainable, non-toxic, and environmentally friendly material used for surface modification in different applications ...
Ganesh Prasad Awasthi +5 more
doaj +1 more source
Photoluminescence of CdSe/ZnS quantum dots in nematic liquid crystals in electric fields
Beilstein Journal of Nanotechnology, 2018 We have experimentally investigated the effect of the reorientation of a nematic liquid crystal (LC) in an electric field on the photoluminescence (PL) of CdSe/ZnS semiconductor quantum dots (QDs).
Margarita A. Kurochkina +2 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Observer-based control for active suspension system with time-varying delay and uncertainty
Advances in Mechanical Engineering, 2019 Time-varying input delay of actuators, uncertainty of model parameters, and input and output disturbances are important issues in the research on active suspension system of vehicle.
Kuiyang Wang +6 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Nanoscale Structural Plasticity of the Active Zone Matrix Modulates Presynaptic Function
Cell Reports, 2017 The active zone (AZ) matrix of presynaptic terminals coordinates the recruitment of voltage-gated calcium channels (VGCCs) and synaptic vesicles to orchestrate neurotransmitter release.
Oleg O. Glebov +7 more
doaj +1 more source