Results 81 to 90 of about 2,358,768 (289)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Synergetic effects of nano-boehmite and Y nano-zeolite on catalytic cracking of residue oil

Scientific Reports
Boehmite nanoparticles and NaY nanozeolite were synthesized by co-precipitation and hydrothermal methods, respectively, and characterized by XRD, FT-IR, TG-DTA, BET, and SEM techniques.
Ehsan Amini, Kamran Ahmadi, Alimorad Rashidi, Amir Ali Youzbashi, Mehran Rezaei, Sakineh Mesgar   +5 more
doaj   +1 more source

Bioenergetic-active hydrogel drives extracellular matrix synthesis for cartilage repair

Bioactive Materials
Bioenergy plays a fundamental role in cartilage anabolic processes such as extracellular matrix (ECM) synthesis. The design of bioenergetic-active materials for accelerating these processes provides a prospective strategy for cartilage repair.
Shangtong Jiang, Ziyang Lan, Xin Zhang, Xulong Liu, Jun Xu, Yanhao Chen, Jiaqi Li, Chen Chen, Danni Liu, Minghao Chen, Jianglin Wang, Yingying Du, Shengmin Zhang   +12 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Piezoelectric composite materials [PDF]

, 1983
A laminated structural devices has the ability to change shape, position and resonant frequency without using discrete motive components. The laminate may be a combination of layers of a piezoelectrically active, nonconductive matrix material.
Kiraly, L. J.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

(3+2) Neutrino Scheme From A Singular Double See-Saw Mechanism

, 2007
We obtain a 3+2 neutrino spectrum within a left-right symmetric framework by invoking a singular double see-saw mechanism. Higgs doublets are employed to break $SU_{R}(2)$ and three additional fermions, singlets under the left-right symmetric gauge group,
A. Mastrano, A. Smirnov, B. H. J. McKellar, D. Du, F. Dydak, K. L. McDonald, K. Lande, M. Apollonio, M. Gell-Mann, T. Yanagida, T. J. Allen, W. Grimus, W. Hampel   +12 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Two Zero Mass Matrices and Sterile Neutrinos

, 2012
Recent experimental data is indicative of the existence of sterile neutrinos. The minimal scheme that can account for the data and is consistent with cosmological observations is the 3+1 picture which consists of three predominantly active and one ...
Ghosh, Monojit, Goswami, Srubabati, Gupta, Shivani   +2 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source