Results 161 to 170 of about 8,578,817 (287)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Optimization of short-circuit current density for tailored active region in BiFeO₃ layer: a computational step into 3rd generation perovskite solar cells. [PDF]

RSC Adv
Ameen M, Bilal M, Salman MU, Luqman M, Ramay SM, Mahmood W, Atiq S.   +6 more
europepmc   +1 more source

Camp No. 14 - granite hills to south-east [picture] /

, 1891
Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an6647833 ...
Elliott, Frederick, active 1855-1897.
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Active Region Mode Control for High-Power, Low-Linewidth Broadened Semiconductor Optical Amplifiers for Light Detection and Ranging. [PDF]

Sensors (Basel)
Tang H, Zhang M, Liang L, Zhang T, Qin L, Song Y, Lei Y, Jia P, Wang Y, Qiu C, Zheng C, Li X, Chen Y, Li D, Ning Y, Wang L.   +15 more
europepmc   +1 more source

Understanding Heating in Active Region Cores through Machine Learning. I. Numerical Modeling and Predicted Observables. [PDF]

Astrophys J, 2019
Barnes WT, Bradshaw SJ, Viall NM.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Kadlunga Station. Shropshires at rest [picture] /

, 1891
Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an11254186 ...
McGann, Terence, active 1891-1900.
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor-ligand signaling complex. [PDF]

Proc Natl Acad Sci U S A
Zeng J, Loi GWZ, Saipuljumri EN, Romero Durán MA, Silva-García O, Perez-Aguilar JM, Baizabal-Aguirre VM, Lo CH.   +7 more
europepmc   +1 more source