Results 101 to 110 of about 18,480,131 (251)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Impact of Screen Time on Diet and Physical Activity among Students at UiTM Puncak Alam [PDF]
This cross-sectional study examines the correlation between screen time, dietary intake, and physical activity among 150 students. Data were collected through a 3-day dietary recall, the International Physical Activity Questionnaire (IPAQ), and a screen ...
Majid, Norhaini +3 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Complementary Therapies in MedicineBackground: While physical activity (PA) provides established benefits for youth (children and adolescents) development, the differential effects of mentally passive versus mentally active screen time (ST) on academic achievement and social behavior ...
Benlu Liao, Maolin Tian
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Screen time vs. lean time : age group 15-18
Do you know how much entertainment screen time kids get? Time in front of a screen is time kids aren't active. See how much scrfeen time kids of different ages get and tips for healthier activities.getmoving_15-18 ...
core
Cajoling screen media students back on-campus – and keeping them there!
, 2023 Research shows that in today’s post-COVID era, “student engagement” at university has declined, and with it, attrition has increased. Like many universities, a cohort of students at the researchers’ university are dissatisfied with rapid online learning ...
Bentley, Rachel (R15033) +1 more
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Screen time vs. lean time : age group 8-10
Do you know how much entertainment screen time kids get? Time in front of a screen is time kids aren't active. See how much scrfeen time kids of different ages get and tips for healthier activities.getmoving_8-10 ...
core