Results 121 to 130 of about 17,725,252 (297)
BMJ Public HealthBackground The widespread ownership of digital devices among adolescents presents challenges and opportunities in schools, particularly during recess.
Soren Brage +9 more
doaj +1 more source
The Impact of Physical Activity and Screen Time on Motor Creativity in Kindergarteners
ChildrenBackground/Objectives: Motor creativity and physical activity are essential to early childhood development, impacting physical, cognitive, and socio-emotional development. This study investigates the relationships among motor creativity, motor working memory (MSTM), screen time, and physical activity (PA) in kindergarten children, focusing on the ...
openaire +3 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
The influence of screen time on preschooler's fluid intelligence
reservedDiversi studi hanno analizzato gli effetti dell'esposizione agli schermi (screen time) sugli aspetti cognitivi, emotivi, sociali, comportamentali e fisici di bambini e adulti. La letteratura al riguardo è tuttavia discordante in quanto a seconda
ORLANDI, LUISA
core
Complementary Therapies in MedicineBackground: While physical activity (PA) provides established benefits for youth (children and adolescents) development, the differential effects of mentally passive versus mentally active screen time (ST) on academic achievement and social behavior ...
Benlu Liao, Maolin Tian
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Frontiers in PsychiatryIntroductionOur society’s reliance on smartphones is a growing phenomenon. Misuse or overuse of smartphones has been associated with negative effects on physical health and psychological functioning, including reduced quality of sleep when used before ...
Thao Hanh Vu, Marco Tagliabue
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source