Results 181 to 190 of about 32,212 (230)

Activins and activin antagonists in the prostate and prostate cancer

Molecular and Cellular Endocrinology, 2012
Activins are members of the TGF-β super-family. There are 4 mammalian activin subunits (β(A), β(B), β(C) and β(E)) that combine to form functional proteins. The role of activin A (β(A)β(A)) is well characterized and known to be a potent growth and differentiation factor.
Gail Risbridger, Elspeth Gold
exaly   +3 more sources

Activin A and Activin Receptors in Thyroid Cancer

Thyroid, 2001
Proliferation is controlled by a network of mitogenic and growth inhibitory factors. Transforming growth factor-beta1 (TGF-beta1) and activin A are the most important growth inhibitors of benign follicular epithelial cells of the human thyroid. The effects of these substances on malignant primary thyrocytes are not known.
K M, Schulte, C, Jonas, R, Krebs, H D, Röher   +3 more
openaire   +2 more sources

Inhibins and Activins

1988
Publisher Summary This chapter discusses the isolation, structure, characterization, and biosynthesis of inhibins and activins. The two pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) which regulate the development and maturation of the gonad, are identified.
N, Ling, N, Ueno, S Y, Ying, F, Esch, S, Shimasaki, M, Hotta, P, Cuevas, R, Guillemin   +7 more
openaire   +2 more sources

Activin, Activin-Binding Protein (Follistatin) and Activin Receptor

1993
The principal regulators of the pituitary gonadotropins LH and FSH in mammals are the gonadotropin-releasing hormone (GnRH) from the hypothalamus and the gonadal steroids.
Hiromu Sugino, Takanori Nakamura, Kishiko Sugino, Koiti Titani   +3 more
openaire   +1 more source

Activin A In Brain Injury

2007
Activin A is a growth factor composed of two betaA subunits belonging to the transforming growth factor beta (TGF-beta) superfamily of dimeric proteins. The biological activity of activin A is mediated by two different types of receptors, the type I (ARI and ARIB) and the type II receptors (ARII and ARIIB), and by two activin-binding proteins ...
Florio, Pasquale, Gazzolo, Diego, Luisi, Stefano, Petraglia, Felice   +3 more
openaire   +3 more sources

Activins and activin antagonists in the human ovary and ovarian cancer

Molecular and Cellular Endocrinology, 2015
Activins are members of the transforming growth factor β superfamily that play an important role in controlling cell proliferation and differentiation in many organs including the ovary. It is essential that activin signalling be tightly regulated as imbalances can lead to uncontrolled cell proliferation and cancer. This review describes the expression
Karen L, Reader, Elspeth, Gold
openaire   +2 more sources

Localization of an activin/activin receptor system in the porcine ovary

Molecular Reproduction and Development, 2001
AbstractThe aim of this study was to locate a possible activin/activin receptor system within porcine ovaries containing functional corpora lutea. In situ hybridization was used to assess the gene expression of βA‐ and βB‐activin subunits, and immunohistochemical studies were done to detect activin‐A protein and activin receptor type II.
van den Hurk, R., van der Pavert, S.A.
openaire   +3 more sources

Inhibins and activins in pregnancy

Molecular and Cellular Endocrinology, 2004
Human placenta, decidua, and fetal membranes are the major sites of production and secretion of inhibin A and activin A in maternal serum, amniotic fluid, and umbilical cord blood. These tissues also express follistatin-related gene and betaglycan, the binding proteins of activin A and inhibin A, respectively, recently identified. They show a different
FLORIO, P., LUISI, S., CIARMELA, P., SEVERI, F. M., BOCCHI, C., PETRAGLIA, F.   +5 more
openaire   +5 more sources

Characterization of Activin A-, Activin-AB and Activin-B-Responding Cells by Their Responses to Hypothalamic Releasing Hormones

Biochemical and Biophysical Research Communications, 1994
Activin A-, AB- and B-responding cells were characterized by their responsiveness in cytosolic free calcium ([Ca2+])i) to four hypothalamic releasing hormones, CRH, GHRH, TRH and GnRH. First, rat pituitary cells responding to activin A, AB and B in [Ca2+]i were determined in a mixed population of pituitary cells. The populations of the activin A-, AB-,
K, Tasaka, K, Kasahara, N, Masumoto, J, Mizuki, K, Fukami, A, Miyake, T, Nakamura, H, Sugino   +7 more
openaire   +2 more sources

Activins and Inhibins and Their Signaling

Annals of the New York Academy of Sciences, 2004
Abstract: Activins and inhibins, which were discovered by virtue of their abilities to stimulate or inhibit, respectively, the secretion of FSH, are members of the transforming growth factor‐β (TGFβ) superfamily and exert a broad range of effects on the diffentiation, proliferation and functions of numerous cell types.
Wylie, Vale, Ezra, Wiater, Peter, Gray, Craig, Harrison, Louise, Bilezikjian, Senyon, Choe   +5 more
openaire   +2 more sources