Results 111 to 120 of about 14,689 (206)

Presurgical miR‐675‐5p Associates With the Inflammatory Response Following Surgery and Increases Inflammatory Gene Expression In Vitro

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background A loss of muscle mass and strength is a marker of poor outcomes following surgery. Changes in muscle gene expression following surgery are likely to contribute to postsurgical muscle loss, but the mechanisms controlling these changes are not known. We have previously shown that miRNAs associate with muscle loss in disease, including
Narmin Akhundova, Richard Paul, Benjamin Fletcher, Martin Connolly, Mark J. Griffiths, Paul R. Kemp   +5 more
wiley   +1 more source

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source

Heterotopic Ossification: Molecular Drivers, Subtype-Specific Mechanisms, and Translational Therapeutic Advances. [PDF]

Biomolecules
Chen S, Lin H.
europepmc   +1 more source

Establishment of Human Formative Pluripotent Stem Cell‐Like Cells Exhibiting Amniotic Differentiation Potentials

Cell Proliferation, Volume 59, Issue 8, August 2026.
The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang, Qizhi Wang, Yu Wu, Chen Gu, Mingfei Li, Yong Fan, Xiangjin Kang, Lei Li, Zheng Gao, Mingyan Hei, Jianqiao Liu, Lei Li   +11 more
wiley   +1 more source

The Evolving Landscape of Pulmonary Hypertension Treatment: From Vasodilation to Disease Modification

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Pulmonary hypertension (PH) is a complex disorder associated with significant morbidity and mortality. PH is characterized by an elevated pulmonary vascular load, leading to right ventricular dysfunction and remodeling, with right heart failure and premature death if left untreated.
Surya Ayalasomayajula, Ednan K. Bajwa, Alexandra G. Cornell, Maria Jose Loureiro, Samuel S. Kim, Julia Richmond DiBello, Eric Sterner, Richard Chen, Islam R. Younis   +8 more
wiley   +1 more source

Periodontitis induces skeletal muscle atrophy by increasing circulating levels of activin A. [PDF]

Nat Commun
Shim W, Suh J, Kim HK, Kim NK, Kim Y, Jeong YT, Kim MS, Lee SJ, Lee YS.   +8 more
europepmc   +1 more source

miR‐640 Enhances Abemaciclib Sensitivity by Suppressing CDK Inhibitor Resistance‐Associated Genes in Breast Cancer Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT We investigated the potential of miR‐640 to downregulate CDK4/6 inhibitor resistance‐associated genes and evaluated its apoptotic, anti‐metastatic and anti‐proliferative effects, both alone and in combination with abemaciclib in breast cancer cells. miR‐640 was identified via GSE126125 dataset analysis.
Ismail Mert Alkac, Cigir Biray Avci
wiley   +1 more source

Recurrent evolution of ligand-binding domain multiplicity fine-tunes TGFβ signaling in vertebrates. [PDF]

Nat Commun
Jatzlau J, Trumpp M, Kühlwein J, Obendorf L, Le Y, Kuhl H, Preussner M, Mendez PL, Burkert H, Burdzinski W, Mundlos S, Winkler C, Stöck M, Knaus P.   +13 more
europepmc   +1 more source

Serum Activin A Level and 1-Year Mortality in Atrial Septal Defect-Associated Pulmonary Artery Hypertension: A Case-Control Study From the COHARD-PH Registry. [PDF]

Int J Vasc Med
Rinastiti P, Hartopo AB, Cipta CE, Maharani SG, Anggrahini DW, Emoto N, Dinarti LK.   +6 more
europepmc   +1 more source

Myostatin Research: From Molecular Understanding to Clinical Translation for Musculoskeletal and Metabolic Disorders. [PDF]

Int J Mol Sci
Lei C, Jiang H, Yang X, Ding S, Yu Y, Zhang Z, Wang L, Gao C, Lyu A, Qin L, Zhang G, Zhang BT.   +11 more
europepmc   +1 more source