Results 101 to 110 of about 32,974 (249)

Enhanced differentiation of human embryonic stem cells towards definitive endoderm on ultrahigh aspect ratio nanopillars [PDF]

, 2015
Differentiation of human embryonic stem cells is widely studied as a potential unlimited source for cell replacement therapy to treat degenerative diseases such as diabetes.
Dufva, Martin, Gadegaard, Nikolaj, Hansson, Mattias, Holzmann Rasmussen, Camilla, McMeeking, Robert M., Petersen, Dorthe Roenn, Reynolds, Paul   +6 more
core   +2 more sources

The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Obesity is often accompanied by skeletal muscle atrophy, which aggravates insulin resistance and metabolic dysfunction. Chronic inflammation is implicated in this process, but the molecular mediators linking obesity‐induced inflammation to muscle wasting have remained unclear.
An Liyuan, Yu Hirata, Tomoya Inoue, Kenji Sugawara, Wataru Ogawa   +4 more
wiley   +1 more source

Gonadotropin and kisspeptin gene expression, but not GnRH, are impaired in cFOS deficient mice. [PDF]

, 2015
cFOS is a pleiotropic transcription factor, which binds to the AP1 site in the promoter of target genes. In the pituitary gonadotropes, cFOS mediates induction of FSHβ and GnRH receptor genes.
Coss, Djurdjica, Jonak, Carrie R, Kauffman, Alexander S, Xie, Changchuan   +3 more
core   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Vactosertib, a Novel, Orally Bioavailable Activin Receptor-Like Kinase 5 Inhibitor, Promotes Regression of Fibrotic Plaques in a Rat Model of Peyronie’s Disease

The World Journal of Men's Health, 2020
Purpose: To examine the therapeutic effect of Vactosertib, a small molecule inhibitor of transforming growth factor-β (TGF-β) type I receptor (activin receptor-like kinase-5, ALK5), in an experimental model of Peyronie’s disease (PD) and determining ...
Kang-Moon Song, Doo Yong Chung, Min Ji Choi, Kalyan Ghatak, Nguyen Nhat Minh, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Guo Nan Yin, Dae-Kee Kim, Ji-Kan Ryu, Jun-Kyu Suh   +11 more
doaj   +1 more source

Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. [PDF]

J Biol Chem, 2022
Chu KY, Malik A, Thamilselvan V, Martinez-Hackert E.   +3 more
europepmc   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder

Frontiers in Molecular Biosciences
The activin-follistatin-inhibin (AFI) axis plays a crucial role in sexual development and reproduction. Recently it was demonstrated that these proteins are also synthesized by many local tissues and regulate different biological activities, including ...
Weipu Mao, Tracy Zhang, Huan Chen, Sagar Barge, Zongwei Wang, Aria Olumi, Seth Alper, Weiqun Yu   +7 more
doaj   +1 more source

Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15

Cell Reports, 2018
Summary: The age-related effects of GDF11 have been a subject of controversy. Here, we find that elevated GDF11 causes signs of cachexia in mice: reduced food intake, body weight, and muscle mass.
Juli E. Jones, Samuel M. Cadena, Chenguang Gong, Xiaomei Wang, Zhiping Chen, Sharon X. Wang, Chad Vickers, Hong Chen, Estelle Lach-Trifilieff, John R. Hadcock, David J. Glass   +10 more
doaj   +1 more source

Endothelial‐to‐mesenchymal transition in the fetoplacental macrovasculature and microvasculature in pregnancies complicated by gestational diabetes

The Journal of Physiology, EarlyView.
Abstract figure legend Transforming growth factor (TGF)‐β2 and interleukin (IL)‐1β induced morphological and molecular changes consistent with endothelial‐to‐mesenchymal transition (EndMT) in HUVECs isolated from both pregnancies complicated by gestational diabetes (GDM) and non‐GDM pregnancies.
Abigail R. Byford, Georgia Fakonti, Ziyu Shao, Sharanam Soni, Sophie L. Earle, Muath Bajarwan, Lara C. Morley, Beth Holder, Eleanor M. Scott, Karen Forbes   +9 more
wiley   +1 more source