Maximal expression of Foxl2 in pituitary gonadotropes requires ovarian hormones. [PDF]
PLoS ONE, 2015 Gonadotropin-releasing hormone (GnRH) and activin regulate synthesis of FSH and ultimately fertility. Recent in vivo studies cast SMAD4 and FOXL2 as master transcriptional mediators of activin signaling that act together and independently of GnRH to ...
Maria K Herndon, John H Nilson
doaj +1 more source
Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]
, 2016 Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core +1 more source
Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder [PDF]
, 2018 The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome.
Sugatani, Toshifumi
core +2 more sources
Cripto forms a complex with activin and type II activin receptors and can block activin signaling [PDF]
Proceedings of the National Academy of Sciences, 2003 Activin, nodal, Vg1, and growth and differentiation factor 1 are members of the transforming growth factor β superfamily and signal via the activin type II (ActRII/IIB) and type I (ALK4) serine/threonine kinase receptors. Unlike activins, however, signaling by nodal, Vg1, and growth and differentiation factor 1 requires a coreceptor from the epidermal ...
Peter C, Gray +2 more
openaire +2 more sources
PPAR Research, 2013 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) and activin are implicated in the control of apoptosis, cell proliferation, and inflammation in cells. We examined both the mechanism by which 15d-PGJ2 regulates the transcription of activin-induced activin ...
Seung-Won Park +5 more
doaj +1 more source
A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling [PDF]
, 2019 Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, lethal malignancy that invades adjacent vasculatures and spreads to distant sites before clinical detection.
Alimperti, Styliani +8 more
core +1 more source
The mechanical stimulation of myotubes counteracts the effects of tumor-derived factors through the modulation of the activin/follistatin ratio [PDF]
, 2019 Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Adamo, Sergio +8 more
core +1 more source
Downregulation of Organ-Derived Activin A Attenuates Muscle Atrophy and Intramuscular Fat Infiltration in Cancer Cachexia Mice. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Cancer cachexia is a multifactorial wasting syndrome marked by profound skeletal muscle loss. Tumours can release high levels of Activin A (ActA), which activates the ubiquitin‐proteasome pathway (UPP) and drives muscle wasting.
Wang C +14 more
europepmc +2 more sources
Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids
Advanced Science, EarlyView.Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang +12 more
wiley +1 more source
Communications BiologyThe Activin-A precursor dimer can be cleaved by furin, but how this proteolytic maturation is regulated in vivo and how it facilitates access to signaling receptors is unclear.
Katarina Pinjusic +8 more
doaj +1 more source