Results 81 to 90 of about 32,974 (249)

Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors. [PDF]

PLoS ONE, 2013
Mortality from prostate cancer (PCa) is due to the formation of metastatic disease. Understanding how that process is regulated is therefore critical. We previously demonstrated that endoglin, a type III transforming growth factor β (TGFβ) superfamily ...
Michael J Breen, Diarmuid M Moran, Wenzhe Liu, Xiaoke Huang, Calvin P H Vary, Raymond C Bergan   +5 more
doaj   +1 more source

Characterization of isoforms of activin receptor-interacting protein 2 that augment activin signaling [PDF]

Journal of Endocrinology, 2006
Activin type II receptors (ActRIIs) including ActRIIA and ActRIIB are serine/threonine kinase receptors that form complexes with type I receptors to transmit intracellular signaling of activins, nodal, myostatin and a subset of bone morphogenetic proteins.
Z H, Liu, K, Tsuchida, T, Matsuzaki, Y L, Bao, A, Kurisaki, H, Sugino   +5 more
openaire   +2 more sources

Bright Ferritin for Non‐Invasive MRI Monitoring of the Fate of Transplanted hPSC‐Cardiomyocytes in the Infarcted Rat Heart

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To demonstrate that a recently reported bright ferritin magnetic resonance imaging (MRI) platform can track transplanted human pluripotent stem cell (hPSC)‐derived cardiomyocytes (hPSC‐CMs) longitudinally and on‐demand in the rat heart.
Keyu Zhuang, Faisal J. Alibhai, Beiping Qiang, Rocco Romagnuolo, Kyle D. W. Vollett, Bradley K. C. Freeman, M. Juliana Gomez‐Garcia, Tamilla Sadikov Valdman, Tameshwar Ganesh, Yu‐Qing Zhou, Hai‐Ying Mary Cheng, Michael A. Laflamme, Hai‐Ling Margaret Cheng   +12 more
wiley   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

When it Pays to Rush: Interpreting Morphogen Gradients Prior to Steady-State

, 2009
During development, morphogen gradients precisely determine the position of gene expression boundaries despite the inevitable presence of fluctuations. Recent experiments suggest that some morphogen gradients may be interpreted prior to reaching steady ...
Erdmann T Howard M ten Wolde P R, Houchmandzadeh B, Lander A D, Martin Howard, Timothy Saunders, Wehrli M   +5 more
core   +1 more source

Signal Processing during Developmental Multicellular Patterning [PDF]

, 2008
Developing design strategies for tissue engineering and regenerative medicine is limited by our nascent understanding of how cell populations self-organize into multicellular structures on synthetic scaffolds. Mechanistic insights can be gleaned from the
Asthagiri, Anand R., Giurumescu, Claudiu A.   +1 more
core   +1 more source

Identification of a Drosophila activin receptor. [PDF]

Proceedings of the National Academy of Sciences, 1993
Activins are cytokines of the transforming growth factor beta superfamily that control various events during vertebrate embryo development and cell differentiation in the adult, and act through transmembrane receptors that contain a cytoplasmic protein-serine/threonine kinase domain.
S R, Childs, J L, Wrana, K, Arora, L, Attisano, M B, O'Connor, J, Massagué   +5 more
openaire   +2 more sources

Adaptation of the invasive pest Drosophila suzukii to a specialized nutritional niche

Insect Science, EarlyView.
Unlike most Drosophila larvae that feed on spoiled food, Drosophila suzukii larvae thrive on ripening fruits and consequently face a low‐protein, high‐carbohydrate nutritional challenge. Comparisons of growth among D. suzukii, D. biarmipes, and D. melanogaster larvae across diets with varying protein‐to‐carbohydrate ratios demonstrate that D.
Yan Hou, Ying Zhen
wiley   +1 more source

Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons

eLife, 2020
Establishing appropriate sizes and shapes of dendritic arbors is critical for proper wiring of the central nervous system. Here we report that Insulin-like Peptide 2 (DILP2) locally activates transiently expressed insulin receptors in the central ...
Jiangnan Luo, Chun-Yuan Ting, Yan Li, Philip McQueen, Tzu-Yang Lin, Chao-Ping Hsu, Chi-Hon Lee   +6 more
doaj   +1 more source

EGF and TGF-β1 effects on thyroid function [PDF]

, 2011
Normal epithelial thyroid cells in culture are inhibited by TGF-β1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF-β responsiveness could be due to a reduced expression of TGF-β receptors, as
Gabriella Mincione, Maria Carmela Di Marcantonio, Chiara Tarantelli, D'INZEO, SONIA, NICOLUSSI, Arianna, NARDI, Francesco, Caterina Francesca Donini, COPPA, Anna   +7 more
core   +2 more sources