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Acute-on-Chronic Liver Failure [PDF]

New England Journal of Medicine, 2020
Acute-on-chronic liver failure (ACLF) is a recently recognised and defined syndrome seen in patients with liver cirrhosis and carries a high short-term mortality in excess of 15% at 28 days. ACLF is defined by organ failures (OFs) and is distinct from simple 'acute decompensation' (AD) of cirrhosis.
Vicente Arroyo, Richard Moreau, Rajiv Jalan   +2 more
exaly   +13 more sources

Acute-on-Chronic Liver Failure [PDF]

Dtsch Arztebl Int
Cirrhosis is the end stage of chronic liver disease. Cirrhosis causes portal hypertension, which, in turn, can lead to acute on chronic liver failure (ACLF), which is defined as acute decompensation combined with failure of the liver, coagulation system, kidneys, lungs, and/or circulatory system, or hepatic encephalopathy.This review is based on a ...
Girish V, Mousa OY, Syed K, John S.
europepmc   +9 more sources

Acute-on-chronic liver failure [PDF]

Clinical and Molecular Hepatology, 2013
Acute-on-chronic liver failure (ACLF) is an increasingly recognized distinct disease entity encompassing an acute deterioration of liver function in patients with chronic liver disease.
Tae Yeob Kim, Dong Joon Kim
doaj   +3 more sources

Acute-on-chronic liver failure [PDF]

Lancet, The, 2015
Acute-on-chronic liver failure combines an acute deterioration in liver function in an individual with pre-existing chronic liver disease and hepatic and extrahepatic organ failures, and is associated with substantial short-term mortality. Common precipitants include bacterial and viral infections, alcoholic hepatitis, and surgery, but in more than 40%
William Bernal, Rajiv Jalan, Alberto Quaglia   +2 more
exaly   +6 more sources

Acute-on-Chronic Liver Failure—Current Management and Future Perspectives [PDF]

Biomedicines
Acute-on-chronic liver failure (ACLF) is a distinct clinical syndrome characterized by an acute decompensation of chronic liver disease in association with extrahepatic organ failure(s) and a high short-term mortality.
Benedict Allhoff, Christoph Neumann-Haefelin, Philipp Kasper   +2 more
doaj   +2 more sources

Acute-on chronic liver failure

Journal of Hepatology, 2012
Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality.
Rajiv Jalan, Pere Ginès, Jody C Olson
exaly   +3 more sources

Liver transplantation for acute-on-chronic liver failure [PDF]

Hepatology International, 2009
To evaluate the outcome of liver transplantation for acute-on-chronic liver failure.From November 1991 to December 2007, 517 patients underwent liver transplantation at Queen Mary Hospital, Hong Kong. Among them, 149 had acute-on-chronic liver failure as defined in the recent Asian Pacific Association for the Study of Liver Consensus Meeting.
See Ching Chan, K K C Ng
exaly   +5 more sources

Development and validation of a dynamic prognostic score for hepatitis B virus–related acute-on-chronic liver failure [PDF]

Journal of International Medical Research
Objective Hepatitis B virus–related acute-on-chronic liver failure is a rapidly progressive syndrome associated with high mortality. The aim of this study was to develop a dynamic prognostic score for precise outcome prediction in patients with hepatitis
Jiemenglu Li, Jian Yang, Chunyan Jiang, Qingting Zhao, Yufeng Gao, Jiang Li   +5 more
doaj   +2 more sources

Unbiased clustering of acute-on-chronic liver failure patients using machine learning in a real-world ICU cohort [PDF]

Nature Communications
Acute-on-chronic liver failure is a complex condition with varied definitions, complicating risk stratification and targeted management. We apply unsupervised clustering to data from 1,256 patients with acute-on-chronic liver failure as defined by the ...
Mengyi Zhang, Fanpu Ji, Jian Zu, Yingli He, Tao Chen, Yi Liu, Hirsh D. Trivedi, Ju Dong Yang, Vinay Sundaram, Yuan Wang, Xiaodan Sun, Zhujun Cao, Chun-Ying Wu, Yee Hui Yeo, Rajiv Jalan   +14 more
doaj   +2 more sources

Effect of cirrhosis on prognosis in patients with acute-on-chronic liver failure: a systematic review and meta-analysis [PDF]

PeerJ
Background Acute-on-chronic liver failure (ACLF) is a prevalent complication among cirrhosis patients, whose high mortality is linked to cirrhosis combined with ACLF. Nevertheless, there is a paucity of systematic reviews.
Chunyang Dong, Xiaoxiao Liu, Dongshuai Zhang, Deyou Jiang   +3 more
doaj   +3 more sources