Results 31 to 40 of about 53,571 (225)

The interplay between acute bacterial skin and skin structure infections and depression: a vicious circle of major clinical importance

, 2020
PURPOSE OF REVIEW: Previous studies suggest an association between depression and increased risk of various type of infections, including acute bacterial skin and skin structure infections (ABSSSI).
Marini, M.G., Giamarellos-Bourboulis, E.J., Gournellis, R., Balestrieri, M., Almirante, B., Grande, I., Bassetti, M.   +6 more
core   +3 more sources

Improved economic and clinical outcomes with oritavancin versus a comparator group for treatment of acute bacterial skin and skin structure infections in a community hospital.

PLoS ONE, 2021
BackgroundOritavancin is a lipoglycopeptide antibiotic with in vitro bactericidal activity against gram-positive pathogens indicated for use in adults with acute bacterial skin and skin structure infections (ABSSSI).
Kimberly Saddler, Jason Zhang, Jennifer Sul, Pruthvi Patel, Miriams Castro-Lainez, Mark L Stevens, Sheryl Kosler, Emily Lowery, Miguel Sierra-Hoffman   +8 more
doaj   +1 more source

Pyrazole-Derived Antibacterial Compounds Effectively Treat Methicillin-Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase. [PDF]

Adv Sci (Weinh)
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Yang X, Cao X, Dai L, Yang F, Wang J, Ma Y, Bu T, Gong Z, Liu X, Bai C, Miao X, Shang X.   +11 more
europepmc   +2 more sources

Development of a Risk-Scoring Tool to Determine Appropriate Level of Care in Acute Bacterial Skin and Skin Structure Infections in an Acute Healthcare Setting

Infectious Diseases and Therapy, 2018
Introduction Acute bacterial skin and skin structure infections (ABSSSIs) represent a large burden to the US healthcare system. There is little evidence-based guidance regarding the appropriate level of care for ABSSSIs.
Kimberly C. Claeys, Evan J. Zasowski, Abdalhamid M. Lagnf, Noor Sabagha, Donald P. Levine, Susan L. Davis, Michael J. Rybak   +6 more
doaj   +1 more source

Empiric treatment approach for the management of post-operative incisional infections with omadacycline

Foot & Ankle Surgery: Techniques, Reports & Cases, 2023
: Background: Surgical wound dehiscence (SWD) is one of the most common complications of surgical incision sites after foot surgeries because of blood flow and circulation issues that may occur in the foot. Such SWD complications can potentially lead to
Philip Wrotslavsky
doaj   +1 more source

Mucosal immune responses following intestinal nematode infection. [PDF]

, 2014
In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years).
Harris, N. L., P. J. Cooper, Zaph, C, Cooper, P. J., C. Zaph, Cooper, PJ, Harris, NL, Zaph, C., Cooper, Philip, N. L. Harris   +9 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Cancer is chronic but antimicrobial stewardship is iconic: A retrospective cohort of optimal antibiotic use in ambulatory oncology clinics

Antimicrobial Stewardship & Healthcare Epidemiology, 2023
Objective: To evaluate antibiotic prescribing in ambulatory oncology clinics and to identify opportunities to improve antibiotic use. Methods: Retrospective cohort of adult patients who received care at 4 ambulatory oncology clinics from May 2021 to ...
Tiffany A. Ho, Katelyn M. Patterson, Shirish M. Gadgeel, Rachel M. Kenney, Michael P. Veve   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Necrotizing Fasciitis Within 72 hours After Presentation with Skin and Skin Structure Infection [PDF]

, 2020
Introduction: A small percentage of patients with skin infections later develop necrotizing fasciitis (NF). Diagnostic testing is needed to identify patients with skin infections at low risk of NF who could be discharged from the emergency ...
Dunne, Michael W., Nguyen, H. Bryant, Akinapelli, Karthik, Puttagunta, Sailaja, Ojaimi, Caroline, Rappo, Urania   +5 more
core   +1 more source