Results 1 to 10 of about 1,651 (123)

Deep Learning Enables Identification of Antimicrobial Peptides Through Mechanochromic Fingerprints. [PDF]

Angew Chem Int Ed Engl
We demonstrate a new platform for antimicrobial peptide identification by combining polydiacetylene, hyperspectral imaging, and deep learning. The trained model classifies distinct spectral fingerprints into 14 peptide classes with 96.79% accuracy, revealing previously hidden molecular information beyond conventional colorimetric sensing.
Chen J, Chin CL, Zhu Q, Chao L, Sugihara K.   +4 more
europepmc   +3 more sources

Evaluating oritavancin for Gram-positive infections: a systematic review of on-label and off-label use [PDF]

Drugs in Context
Background: Oritavancin is a long-acting lipoglycopeptide antibiotic approved for acute bacterial skin and skin structure infections (ABSSSI) with potential applicability across difficult-to-treat Gram-positive infections such as osteomyelitis ...
Alex Soriano, Carlo Tascini, Marco Falcone, Laura Morata, Marco Bongiovanni, Federico Pea, Pierluigi Viale   +6 more
doaj   +2 more sources

Oritavancin safety: a real-world pharmacovigilance study of the FAERS database [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundOritavancin, a long-acting lipoglycopeptide antibiotic, demonstrates bactericidal activity against gram-positive pathogens including drug-resistant strains.
Bo Xie, Yu-Fei Zhou, Hai-Chi Song, Xiao-Jiao Cui   +3 more
doaj   +2 more sources

Oritavancin in LVAD related infections - a chance for shortening therapy and improving outcomes [PDF]

BMC Infectious Diseases
Background LVAD utility in heart failure patients is growing. Despite advancement in technology rates of LVAD- related infections remain high limiting outcomes. We aimed to assess the effectiveness and safety of oritavancin for LVAD-related Gram-positive
Marta Załęska-Kocięcka, Szymon Mielczarek, Piotr Góral, Kamil Marcinkiewicz, Katarzyna Byczkowska, Karina Zatorska, Justyna Cieślik, Karolina Paszyń, Aleksandra Tomaszek, Piotr Kołsut, Katarzyna Jóźwik-Plebanek, Jarosław Kuriata, Jarosław Szymański, Przemysław Leszek   +13 more
doaj   +2 more sources

Oritavancin for Gram-Positive Bone and Joint Infections: A Comprehensive Review of the Literature [PDF]

Antibiotics
Background: Bone and joint infections (BJIs), including osteomyelitis, septic arthritis, and periprosthetic joint infections, typically require prolonged antimicrobial therapy and often involve complex outpatient management.
Zain Ahmed Raza, Alex Giannini, Marco Bongiovanni   +2 more
doaj   +2 more sources

Saving Beds and Budgets: Real-World Efficacy, Safety, and Pharmacoeconomics of Long-Acting Lipoglycopeptides (LALs) in a Day Hospital Setting [PDF]

Pathogens
Background: Long-acting lipoglycopeptides (LALs), including dalbavancin and oritavancin, may facilitate outpatient-oriented management of Gram-positive infections by reducing the need for prolonged hospitalization and daily intravenous therapy.
Andrea Marino, Emmanuele Venanzi Rullo, Giuseppe Pipitone, Alessandro Giorgio Geremia, Andrea De Vito, Antonio Albanese, Nicholas Geremia, Alessandro Franzò, Federica Cosentino, Paolo Italia, Maria Elena Ciuppa, Andrea Buzzi, Laura Santoro, Chiara Iaria, Giordano Madeddu, Carmelo Iacobello, Rosa Manuele, Fabrizio Pulvirenti, Bruno Cacopardo, Giuseppe Nunnari   +19 more
doaj   +2 more sources

Oritavancin Multiple Dosing for Complex Infections: A Pharmacokinetic/Pharmacodynamic Simulation Study [PDF]

Pharmaceutics
Background/Objectives: Oritavancin therapy for complex infections remains challenging due to the lack of well-established dosing regimens. The objective of this work was to apply PK/PD modeling and Monte Carlo simulation considering different PK/PD ...
Ana Alarcia-Lacalle, Miguel Ángel Morán-Rodríguez, Laura Morata, Arantxa Isla, Andrés Canut-Blasco, Alicia Rodríguez-Gascón   +5 more
doaj   +2 more sources

Long-Term Therapy with Long-Acting Lipoglycopeptide Antibiotics in the Treatment of Cardiovascular Prosthetic Infections: A Systematic Review [PDF]

Antibiotics
Background: Dalbavancin and oritavancin are long-acting lipoglycopeptides increasingly used off-label for a variety of Gram-positive infections. While their efficacy has been described in osteomyelitis, bacteremia, and infective endocarditis, evidence ...
Francesca Gavaruzzi, Guido Granata, Alessandro Capone, Pierangelo Chinello, Stefania Cicalini   +4 more
doaj   +2 more sources

Oritavancin a Therapeutic Option for Periprosthetic Joint Infections in Selected Cases: A Comprehensive Review [PDF]

Pharmaceuticals
Background: Periprosthetic joint infections (PJIs) remain among the most challenging complications in orthopedic surgery, often requiring prolonged antibiotic therapy and complex surgical interventions.
Rares-Mircea Birlutiu, Victoria Birlutiu
doaj   +2 more sources

Oritavancin in Complicated Bloodstream Infections and Endocarditis in Spain and Italy (ORIBAC Study): A Retrospective Multicenter Observational Study [PDF]

Infectious Diseases and Therapy
Introduction The management of complicated Gram-positive bloodstream infections (cBSI) and infective endocarditis (IE) often requires prolonged intravenous therapy.
Antonio Vena, Laura Mezzogori, Matteo Bassetti, Antonio Mastroianni, Sonia Greco, Valeria Vangeli, Salvador López-Cárdenas, Marina Murillo-Pineda, Sofía de la Villa-Martínez, Agustín Estévez-Prieto, Daniele Roberto Giacobbe, Renato Pascale, Emanuele Pontali, Maria Pilar Ruiz-Seco, Carlos de Andrés David, Ivan Adan, Patricia Muñoz, ORIBAC study group   +17 more
doaj   +2 more sources