Results 11 to 20 of about 2,974 (211)

Oritavancin a Therapeutic Option for Periprosthetic Joint Infections in Selected Cases: A Comprehensive Review [PDF]

Pharmaceuticals
Background: Periprosthetic joint infections (PJIs) remain among the most challenging complications in orthopedic surgery, often requiring prolonged antibiotic therapy and complex surgical interventions.
Rares-Mircea Birlutiu, Victoria Birlutiu
doaj   +2 more sources

Oritavancin in Complicated Bloodstream Infections and Endocarditis in Spain and Italy (ORIBAC Study): A Retrospective Multicenter Observational Study [PDF]

Infectious Diseases and Therapy
Introduction The management of complicated Gram-positive bloodstream infections (cBSI) and infective endocarditis (IE) often requires prolonged intravenous therapy.
Antonio Vena, Laura Mezzogori, Matteo Bassetti, Antonio Mastroianni, Sonia Greco, Valeria Vangeli, Salvador López-Cárdenas, Marina Murillo-Pineda, Sofía de la Villa-Martínez, Agustín Estévez-Prieto, Daniele Roberto Giacobbe, Renato Pascale, Emanuele Pontali, Maria Pilar Ruiz-Seco, Carlos de Andrés David, Ivan Adan, Patricia Muñoz, ORIBAC study group   +17 more
doaj   +2 more sources

Oritavancin: Mechanism of Action [PDF]

Clinical Infectious Diseases, 2012
Oritavancin is a semisynthetic lipoglycopeptide analogue of vancomycin that contains the heptapeptide core common to all glycopeptides. It differs from vancomycin by the presence of a hydrophobic N-4-(4-chlorophenyl)benzyl (also referred to as 4'-chlorobiphenylmethyl) substituent on the disaccharide sugar, the addition of a 4-epi-vancosamine ...
George G Zhanel, Frank Schweizer, James A Karlowsky   +2 more
exaly   +3 more sources

Comparative Analysis of Adverse Drug Reactions Between Oritavancin Diphosphate and Oritavancin-HPβCD Using FAERS Data. [PDF]

Hosp Pharm
Background: Acute bacterial skin and skin structure infections (ABSSSI) are serious infections predominantly caused by Gram-positive pathogens such as Staphylococcus aureus and Streptococcus pyogenes ...
Castellana E, Chiappetta MR.
europepmc   +2 more sources

Difficult-to-Treat Skin and Soft Tissue Infections Caused by Panton-Valentine Leukocidin-Producing Community-Associated Methicillin-Resistant Staphylococcus aureus: A Case Series [PDF]

Infectious Disease Reports
Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as a genetically distinct lineage from healthcare-associated MRSA (HA-MRSA), often producing Panton-Valentine leukocidin (PVL) and causing severe skin and ...
Luca Pipitò, Chiara Vincenza Mazzola, Giulio D’Agati, Eleonora Bono, Raffaella Rubino, Silvia Bonura, Claudia Gioè, Teresa Fasciana, Antonio Cascio   +8 more
doaj   +2 more sources

Oritavancin Versus Daptomycin for Osteomyelitis Treatment After Surgical Debridement

Infectious Diseases and Therapy
Introduction Weekly intravenous (IV) oritavancin and daily daptomycin were compared in an outpatient setting following extensive surgical debridement for treating patients with osteomyelitis.
Nicholas W. Van Hise, Russell M. Petrak, Kairav Shah, Melina Diaz, Vishnu Chundi, Mark Redell   +5 more
doaj   +3 more sources

A Comparative Review of the Pharmacology of Dalbavancin and Oritavancin for Gram-Positive Infections: Birds of a Feather or Apples and Oranges? [PDF]

Infectious Diseases and Therapy
The clinical landscape of Gram-positive infections has been reshaped with the introduction of long-acting lipoglycopeptides, particularly dalbavancin and oritavancin.
Maytham Hussein, James Barclay, Mark Baker, Yuezhou Wu, Varsha J. Thombare, Nitin Patil, Ananya B. Murthy, Rajnikant Sharma, Gauri G. Rao, Mark A. T. Blaskovich, Jian Li, Tony Velkov   +11 more
doaj   +2 more sources

One-Shot, One Opportunity: Retrospective Observational Study on Long-Acting Antibiotics for SSTIs in the Emergency Room—A Real-Life Experience [PDF]

Pathogens
Background: Skin and soft tissue infections (SSTIs) are a major cause of emergency room (ER) visits and hospitalizations. Long-acting lipoglycopeptides (LALs), such as dalbavancin and oritavancin, offer potential for early discharge and outpatient ...
Giacomo Ciusa, Giuseppe Pipitone, Alessandro Mancuso, Stefano Agrenzano, Claudia Imburgia, Agostino Massimo Geraci, Alberto D’Alcamo, Luisa Moscarelli, Antonio Cascio, Chiara Iaria   +9 more
doaj   +2 more sources

What Place Is There for Long-Acting Antibiotics in the Management of Gram-Positive Infections? A Qualitative Cross-Sectional Study [PDF]

Antibiotics
Objectives. To identify the current practices with long half-life lipoglycopeptides (LGPs) and potential use/position of oritavancin. Results.
Aurélien Dinh, Guillaume Béraud, Johan Courjon, Yann Le Goff, Nicolas Kader Ettahar, Matthieu Grégoire, Eric Senneville   +6 more
doaj   +2 more sources

Improved economic and clinical outcomes with oritavancin versus a comparator group for treatment of acute bacterial skin and skin structure infections in a community hospital.

PLoS ONE, 2021
BackgroundOritavancin is a lipoglycopeptide antibiotic with in vitro bactericidal activity against gram-positive pathogens indicated for use in adults with acute bacterial skin and skin structure infections (ABSSSI).
Kimberly Saddler, Jason Zhang, Jennifer Sul, Pruthvi Patel, Miriams Castro-Lainez, Mark L Stevens, Sheryl Kosler, Emily Lowery, Miguel Sierra-Hoffman   +8 more
doaj   +1 more source