Results 31 to 40 of about 2,974 (211)

Expediting Discharge in Hospitalized, Adult Patients with Skin and Soft Tissue Infections Who Received Empiric Vancomycin Therapy with Oritavancin: Description of Findings from an Institutional Pathway

Drugs - Real World Outcomes, 2020
Background An internal quality assurance review at AtlantiCare Regional Medical Center (ARMC) revealed that patients admitted with skin and soft tissue infections (SSTIs) remained in hospital post-resolution of acute symptoms and demonstrated a delayed ...
Cristen Whittaker, Thomas P. Lodise, Ethan Nhan, Joseph Reilly   +3 more
doaj   +1 more source

Early Directed Oritavancin Therapy in the Emergency Department May Lead to Hospital Avoidance Compared to Standard Treatment for Acute Bacterial Skin and Skin Structure Infections: A Real-World Retrospective Analysis

Drugs - Real World Outcomes, 2020
Objectives Acute bacterial skin and soft tissue infections (ABSSSIs) are a leading cause of presentation to the emergency department (ED). This study aimed to determine the potential impact of utilizing oritavancin in the ED or observation unit (OBS) on ...
Brittany Helton, Ashley MacWhinnie, Sarah Brooks Minor, Thomas P. Lodise, Kelly D. Rafferty, Steven L. Allison   +5 more
doaj   +1 more source

Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect [PDF]

, 2018
Background Glycopeptide antibiotics inhibit bacterial cell-wall synthesis, and are important for the treatment of infections caused by multi drug-resistant strains of enterococci, streptococci and staphylococci.
Santos Beneit, Fernando
core   +1 more source

New antimicrobials [PDF]

, 2017
Since 2010 the new antimicrobials introduced have activity against resistant Gram negative bacteria, long half-lives against Gram positive bacteria, better activity against Clostridium difficile, and safer antifungal properties. Limiting factors to using
Roland, Will
core   +1 more source

Treatment of Acute Osteomyelitis with Once-Weekly Oritavancin: A Two-Year, Multicenter, Retrospective Study

Drugs - Real World Outcomes, 2020
Background Acute osteomyelitis is typically caused by Gram-positive pathogens, commonly antibiotic-resistant Staphylococcus species. Standard antibiotic treatment is challenging due to required multiple daily doses, therapeutic drug monitoring, and ...
Nicholas W. Van Hise, Vishnu Chundi, Vishal Didwania, Michael Anderson, David McKinsey, Ingrid Roig, Akhilesh Sharma, Russell M. Petrak   +7 more
doaj   +1 more source

Comparative Activity of Lipoglycopeptide Antibiotics Against Gram-Positive Bacteria

Антибиотики и Химиотерапия, 2022
Lipoglycopeptide antibiotics are semi-synthetic derivatives of glycopeptides and are characterized by a pronounced bactericidal activity against gram-positive pathogens.
V. V. Gostev, O. S. Sulian, O. S. Kalinogorskaya, L. N. Popenko, A. N. Kruglov, S. A. Gordeeva, E. V. Nesterova, D. P. Gladin, N. N. Trophimova, P. S. Chulkova, I. V. Ageevets, V. A. Ageevets, T. V. Chernenkaya   +12 more
doaj   +1 more source

Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics [PDF]

, 2009
Novel therapeutic strategies are urgently needed for the treatment of serious diseases caused by viral, bacterial and parasitic infections, because currently used drugs are facing the problem of rapidly emerging resistance.
Bernardini, F, Bisang, C, DeMarco, S J, Gombert, F O, Moehle, K, Obrecht, D, Robinson, J A   +6 more
core   +1 more source

Role of Oritavancin in the Treatment of Infective Endocarditis, Catheter- or Device-Related Infections, Bloodstream Infections, and Bone and Prosthetic Joint Infections in Humans: Narrative Review and Possible Developments

Life, 2023
Oritavancin is a long-acting lipoglycopeptide with in vitro activity against Gram-positive pathogens, as well as good bactericidal activity and sterilisation ability in biofilm. It has been approved for acute bacterial skin and skin structure infections (
Tommaso Lupia, Ilaria De Benedetto, Roberta Bosio, Nour Shbaklo, Francesco Giuseppe De Rosa, Silvia Corcione   +5 more
doaj   +1 more source

Beyond conventional antibiotics for the future treatment of methicillin-resistant Staphylococcus aureus infections: two novel alternatives. [PDF]

, 2012
The majority of antibiotics currently used to treat methicillin-resistant Staphylococus aureus (MRSA) infections target bacterial cell wall synthesis or protein synthesis. Only daptomycin has a novel mode of action.
Devocelle, Marc, Fitzgerald-Hughes, Deirdre, Humphreys, Hilary   +2 more
core   +1 more source

Oritavancin for the treatment of complicated gram-positive infection in persons who inject drugs

BMC Pharmacology and Toxicology, 2020
Background Treatment of complicated infections in persons who inject drugs (PWID) and patients experiencing homelessness poses a unique challenge to clinicians.
Aileen Ahiskali, Heather Rhodes
doaj   +1 more source