Results 41 to 50 of about 1,651 (123)

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, Volume 22, Issue 16, 17 March 2026.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Evaluating the Effect of Therapeutic Antibiotics in Prosthetic Joint Infections Culturing: A Narrative Review

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims One of the important complications of knee and hip replacement arthroplasty is prosthetic joint infection (PJI), which is usually accompanied by negative culture that leads to severe consequences compared to positive ones. This study aims to evaluate the arbitrary use or mistreatment of antibiotics for therapeutic purposes ...
Moein Zangiabadian, Mehrdad Jafari Tadi, Fateme Yousefimoghaddam, Ali Zangiabadian, Amir Ghaffari Jolfayi   +4 more
wiley   +1 more source

Vascular Graft Impregnation with a Fosfomycin/Oritavancin Combination to Prevent Early Infection

Pharmaceutics
Background/Objectives: Vascular graft infections (VGIs) represent a life-threatening complication, occurring in 0.2–6% of patients following aortic prosthetic placements. Historically, the primary focus for reducing VGIs has been on prevention. Currently,
Inês Cruz, Stefano Di Bella, Mario D’Oria, Cristina Lagatolla, M. Cristina L. Martins, Cláudia Monteiro   +5 more
doaj   +1 more source

Glycopeptide Hypersensitivity and Adverse Reactions

Pharmacy, 2020
Glycopeptides, such as vancomycin and teicoplanin, are primarily used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, such as cellulitis, endocarditis, meningitis, pneumonia, and septicemia, and are some of the most ...
Vanthida Huang, Nicola A. Clayton, Kimberly H. Welker   +2 more
doaj   +1 more source

Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis

Annals of Clinical Microbiology and Antimicrobials, 2022
Background Methicillin-resistant Staphylococcus aureus (MRSA) infections are considered an important public health problem, and treatment options are limited.
Fei Liu, Sajad Rajabi, Chunhua Shi, Ghazale Afifirad, Nazanin Omidi, Ebrahim Kouhsari, Saeed Khoshnood, Khalil Azizian   +7 more
doaj   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon, Victoria R. Wong, Samuelson E. Osifo, Timothy Edwards, Himanshu Rao, Jewelia Rempuszewski, Andrew J. Frear, Shaan Sadhwani, Neel B. Shah, Kenneth L. Urish   +9 more
wiley   +1 more source

Vancomycin‐Functionalized Nanodelivery Systems for Antibacterial Tissue Engineering Scaffolds

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review consolidates recent advancements in VAN nanoformulations, critically evaluating their design principles, release mechanisms, and efficacy profiles against resistant Gram‐positive pathogens. While promising in vitro and in vivo results have been demonstrated, the clinicaltranslation of these technologies necessitates further rigorous ...
Nima Beheshtizadeh, Mahsa Mohammadzadeh, Amir Abbas Seraji, Ali Pirsadeghi, Elham Zendedel, Maliheh Gharibshahian   +5 more
wiley   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Efficacy and safety of novel glycopeptides versus vancomycin for the treatment of gram-positive bacterial infections including methicillin resistant Staphylococcus aureus: A systematic review and meta-analysis.

PLoS ONE, 2021
ObjectiveTo compare between current evidence of novel glycopeptides against vancomycin for the treatment of gram-positive bacterial infections.MethodologyA systematic review and meta-analysis was done.
Wissal Jame, Bilgen Basgut, Abdikarim Abdi   +2 more
doaj   +1 more source

Medical source control with oritavancin in complicated gram-positive bacterial infections: A case series

International Journal of Infectious Diseases
Objectives: This retrospective observational case series describes a population with complicated gram-positive infections treated with oritavancin as part of a highly individualized strategy.
Francesco Giuseppe De Rosa, Tommaso Lupia, Valentina Fornari, Rita Viglianti, Saverio Marena, Antonio Curtoni, Francesca Molino, Francesca Canta, Simone Mornese Pinna, Silvia Scabini, Ilaria De Benedetto, Silvia Corcione   +11 more
doaj   +1 more source