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Nature Reviews Disease Primers, 2021 Acute kidney injury (AKI) is defined by a sudden loss of excretory kidney function. AKI is part of a range of conditions summarized as acute kidney diseases and disorders (AKD), in which slow deterioration of kidney function or persistent kidney dysfunction is associated with an irreversible loss of kidney cells and nephrons, which can lead to chronic ...
J. Kellum +5 more
semanticscholar +6 more sources
Clinical Medicine, 2009 The term acute kidney injury (AKI) has now replaced the term acute renal failure (ARF) and represents the entire spectrum of the latter. It is best characterised by a rapid decline in kidney function over hours to weeks with the retention of nitrogenous waste products and creatinine.
M. Rosner
semanticscholar +4 more sources
BioMed Research International, 2015 Acute kidney injury (AKI) is a frequent and serious clinical condition which is associated with poor outcomes, including high mortality rate. Classically, it was considered as an acute condition, potentially reversible with full restitution if patient survives the acute phase of the disease.
Raúl Lombardi +3 more
+16 more sources
Revista da Associação Médica Brasileira, 2020 Acute renal failure definitions have changed dramatically over the last 5 to 10 years as a result of criteria established through the following consensus statements/organizations: RIFLE (Risk, Injury, Failure, Loss of function, End stage renal disease), AKIN (Acute Kidney Injury Network), and KDIGO (Kidney Disease: Improving Global Outcomes).
Carlos V.R. Brown +2 more
+9 more sources
Annual Review of Medicine, 2016 Simple acid-base disorders are defined by changes in pH and the initial change in 1 of the 2 variables, serum bicarbonate (HCO3-) and PCO2. Low pH indicates acidosis, and high pH indicates alkalosis. If 1 of the 2 components (HCO3-or PCO2) decreases, the other component also decreases (a compensatory change that minimizes the change in the ratio and ...
Ankit Sakhuja, Kianoush Kashani
+11 more sources
A clinically applicable approach to continuous prediction of future acute kidney injury
Nature, 2019 Alan Karthikesalingam +2 more
exaly +2 more sources
BMJ Open Quality, 2021 Acute kidney injury (AKI) is a common health issue. It is a sudden episode of kidney failure that is almost entirely associated with episodes of acute illness.
Becky Bonfield
doaj +1 more source
Journal of Injury and Violence Research, 2014 Acute kidney injury is a frequent and serious complication in hospitalized patients. Mortality rates have not substantially been decreased during the last 20 years. In most patients AKI results from transient renal hypoperfusion or ischemia. The consequences include tubular cell dysfunction/damage, inflammation of the organ, and post-ischemic ...
Patschan, Daniel, Müller, Gerhard Anton
+10 more sources
Critical Care, 2022 Background Several biomarkers have been proposed to predict the occurrence of acute kidney injury (AKI); however, their efficacy varies between different trials.
Heng-Chih Pan +17 more
doaj +1 more source
Mitochondria ROS and mitophagy in acute kidney injury
Autophagy, 2022 Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged mitochondria and the production of reactive oxygen species (ROS).
L. Su +4 more
semanticscholar +1 more source