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Experimental Models of Acute Lung Injury to Study Inflammation and Pathophysiology: A Narrative Review [PDF]
AntioxidantsAcute lung injury (ALI) is characterized by acute respiratory insufficiency, including tachypnea, cyanosis refractory to oxygen, decreased lung compliance, and diffuse alveolar infiltrates, which is a condition associated with high morbidity and ...
Akinori Cardozo Nagato +4 more
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Clinical Medicine, 2011 #### Key points Acute lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS) are the pulmonary manifestations of an acute systemic inflammatory process characterised clinically by pulmonary infiltrates, hypoxaemia and oedema.
Dhruv, Parekh +2 more
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Current Problems in Surgery, 2020 Acute lung injury causes three major pathologic patterns of injury to the lung. These include acute and organizing diffuse alveolar damage, organizing pneumonia, and acute fibrinous organizing pneumonia. This pathology is characteristically temporally uniform, i.e., occurs at a single point in time, and is found in the setting of overlapping clinical ...
Nathan T. Mowery +2 more
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Critical Care Explorations, 2021 OBJECTIVES:. Hyper- and hypoinflammatory subphenotypes discovered in patients with acute respiratory distress syndrome predict clinical outcomes and therapeutic responses. These subphenotypes may be important in broader critically ill patient populations
Callie M. Drohan, MD +8 more
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Research Progress of Ferroptosis in Acute Lung Injury [PDF]
Zhongguo quanke yixue, 2023 Ferroptosis, a novel programmed cell death characterized by intracellular accumulation of lipid peroxides, has played an important role in a wide range of diseases. Acute lung injury is a critical illness caused by several reasons, and the mortality rate
ZHOU Sijiang, NING Zong
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Factor H preserves alternative complement function during ARDS, linked to improved survival
ERJ Open Research, 2023 Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain +11 more
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Pediatric acute lung injury [PDF]
Paediatric Respiratory Reviews, 2007 Among ventilated children, the incidence of acute lung injury (ALI) was 9%; of that latter group 80% developed the acute respiratory distress syndrome (ARDS). The population-based prevalence of pediatric ARDS was 5.5 cases/100.000 inhabitants.
P, Dahlem, W M C, van Aalderen, A P, Bos
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Hyperoxic Acute Lung Injury [PDF]
Respiratory Care, 2013 Prolonged breathing of very high F(IO(2)) (F(IO(2)) ≥ 0.9) uniformly causes severe hyperoxic acute lung injury (HALI) and, without a reduction of F(IO(2)), is usually fatal. The severity of HALI is directly proportional to P(O(2)) (particularly above 450 mm Hg, or an F(IO(2)) of 0.6) and exposure duration.
Kallet, Richard H, Matthay, Michael A
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Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
Frontiers in Immunology, 2021 The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized.
Hernán F. Peñaloza +5 more
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