Results 1 to 10 of about 302,494 (119)

Experimental Models of Acute Lung Injury to Study Inflammation and Pathophysiology: A Narrative Review [PDF]

Antioxidants
Acute lung injury (ALI) is characterized by acute respiratory insufficiency, including tachypnea, cyanosis refractory to oxygen, decreased lung compliance, and diffuse alveolar infiltrates, which is a condition associated with high morbidity and ...
Akinori Cardozo Nagato, Pedro Alves Machado-Junior, Samuel Santos Valenca, Remo Castro Russo, Frank Silva Bezerra   +4 more
doaj   +2 more sources

Biomarker-Based Classification of Patients With Acute Respiratory Failure Into Inflammatory Subphenotypes: A Single-Center Exploratory Study

Critical Care Explorations, 2021
OBJECTIVES:. Hyper- and hypoinflammatory subphenotypes discovered in patients with acute respiratory distress syndrome predict clinical outcomes and therapeutic responses. These subphenotypes may be important in broader critically ill patient populations
Callie M. Drohan, MD, S. Mehdi Nouraie, MD, PhD, William Bain, MD, Faraaz A. Shah, MD, MPH, John Evankovich, MD, Yingze Zhang, PhD, Alison Morris, MD, MS, Bryan J. McVerry, MD, Georgios D. Kitsios, MD, PhD   +8 more
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Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection

mBio, 2021
Pseudomonas ...
Hernán F. Peñaloza, Tolani F. Olonisakin, William G. Bain, Yanyan Qu, Rick van der Geest, Jill Zupetic, Mei Hulver, Zeyu Xiong, Michael W. Newstead, Chunbin Zou, Jonathan K. Alder, Joel A. Ybe, Theodore J. Standiford, Janet S. Lee   +13 more
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Research Progress of Ferroptosis in Acute Lung Injury [PDF]

Zhongguo quanke yixue, 2023
Ferroptosis, a novel programmed cell death characterized by intracellular accumulation of lipid peroxides, has played an important role in a wide range of diseases. Acute lung injury is a critical illness caused by several reasons, and the mortality rate
ZHOU Sijiang, NING Zong
doaj   +1 more source

Factor H preserves alternative complement function during ARDS, linked to improved survival

ERJ Open Research, 2023
Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain, Mohammadreza Tabary, Sara R. Moore, Xiaojing An, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Viviana P. Ferreira, Janet S. Lee, S. Mehdi Nouraie   +11 more
doaj   +1 more source

Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases

Frontiers in Immunology, 2021
The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized.
Hernán F. Peñaloza, Rick van der Geest, Joel A. Ybe, Theodore J. Standiford, Janet S. Lee, Janet S. Lee   +5 more
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Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionKlebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in ...
Rick van der Geest, Hongye Fan, Hernán F. Peñaloza, William G. Bain, William G. Bain, Zeyu Xiong, Naina Kohli, Emily Larson, Mara L. G. Sullivan, Jonathan M. Franks, Donna B. Stolz, Ryota Ito, Kong Chen, Yohei Doi, Yohei Doi, Melanie J. Harriff, Melanie J. Harriff, Janet S. Lee, Janet S. Lee, Janet S. Lee   +19 more
doaj   +1 more source

FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells

Respiratory Research, 2018
Background The ubiquitin-proteasome pathway, mediated in part, by ubiquitin E3 ligases, is critical in regulating cellular processes such as cell proliferation, apoptosis, and migration.
Tomeka L. Suber, Ina Nikolli, Michael E. O’Brien, James Londino, Jing Zhao, Kong Chen, Rama K. Mallampalli, Yutong Zhao   +7 more
doaj   +1 more source

A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells

Frontiers in Pharmacology, 2022
Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the composition of glandular secretions.
John Villandre, John Villandre, Virginia White, Travis B. Lear, Travis B. Lear, Yanwen Chen, Ferhan Tuncer, Emily Vaiz, Beyza Tuncer, Karina Lockwood, Dan Camarco, Yuan Liu, Yuan Liu, Yuan Liu, Bill B. Chen, Bill B. Chen, Bill B. Chen, John Evankovich, John Evankovich   +18 more
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Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury

EBioMedicine, 2016
Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown.
Jing Zhao, Jianxin Wei, Su Dong, Rachel K. Bowser, Lina Zhang, Anastasia M. Jacko, Yutong Zhao   +6 more
doaj   +1 more source