Results 31 to 40 of about 542,420 (309)

Sustained inflation at birth did not alter lung injury from mechanical ventilation in surfactant-treated fetal lambs. [PDF]

, 2014
BackgroundSustained inflations (SI) are used with the initiation of ventilation at birth to rapidly recruit functional residual capacity and may decrease lung injury and the need for mechanical ventilation in preterm infants.
Hillman, Noah H, Jobe, Alan H, Kallapur, Suhas G, Kemp, Matthew W, Miura, Yuichiro   +4 more
core   +2 more sources

Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection.

JCI Insight, 2019
Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal acute lung injury (ALI) by driving hypercytokinemia and aggressive inflammation through ...
Li Liu, Q. Wei, Q. Lin, Jun Fang, Haibo Wang, H. Kwok, Hangying Tang, K. Nishiura, Jie Peng, Z. Tan, Tongjin Wu, Ka-wai Cheung, Kwok-Hung Chan, X. Alvarez, C. Qin, A. Lackner, S. Perlman, K. Yuen, Zhiwei Chen   +18 more
semanticscholar   +1 more source

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

Cellular & Molecular Biology Letters, 2020
Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis in lipopolysaccharide (LPS)-induced acute lung injury (ALI) has not been explored
Pengfei Liu, Yetong Feng, Hanwei Li, Xin Chen, Guangsuo Wang, Shiyuan Xu, Yalan Li, Lei Zhao   +7 more
semanticscholar   +1 more source

Acute lung injury - from pathophysiology to treatment.

Physiological Research, 2021
Acute lung injury is characterized by acute respiratory insufficiency with tachypnea, cyanosis refractory to oxygen, decreased lung compliance, and diffuse alveolar infiltrates on chest X-ray.
D. Mokra
semanticscholar   +1 more source

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Nature Communications, 2017
How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.
Joseph S. Bednash, Nathaniel Weathington, James Londino, Mauricio Rojas, Dexter L. Gulick, Robert Fort, SeungHye Han, Alison C. McKelvey, Bill B. Chen, Rama K. Mallampalli   +9 more
doaj   +1 more source

Adipose-derived stem cells weigh in as novel therapeutics for acute lung injury [PDF]

, 2014
Acute lung injury is characterized by intense neutrophilic lung inflammation and increased alveolar-capillary barrier permeability leading to severe hypoxemia, and is associated with high mortality despite improvements in supportive care.
Gupta, Kushagra, Hergrueter, Anja, Owen, Caroline A   +2 more
core   +1 more source

Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury

Frontiers in Immunology, 2020
The lung is a primary organ for gas exchange in mammals that represents the largest epithelial surface in direct contact with the external environment.
Vijay Kumar
semanticscholar   +1 more source

The role of ferroptosis in acute lung injury

Molecular and Cellular Biochemistry, 2022
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common disease with high morbidity and mortality, and its pathogenesis is believed to be related to oxidative stress, apoptosis, inflammation, and hypoxia.
Xin Liu, Junqiang Zhang, Wang Xie
semanticscholar   +1 more source

The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor

Journal of Immunology Research, 2015
Interleukin- (IL-) 22 signaling is protective in animal models of pneumonia and bacteremia by Klebsiella pneumoniae and mediates tissue recovery from influenza and Staph aureus infection.
Joseph Franz, Jacob Jerome, Travis Lear, Qiaoke Gong, Nathaniel M. Weathington   +4 more
doaj   +1 more source

E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia

Cell Reports, 2014
Summary: Acute lung injury (ALI) is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are linked on the molecular level. Cardiolipin, a mitochondrial-specific lipid, is generated by
Bill B. Chen, Tiffany A. Coon, Jennifer R. Glasser, Chunbin Zou, Bryon Ellis, Tuhin Das, Alison C. McKelvey, Shristi Rajbhandari, Travis Lear, Christelle Kamga, Sruti Shiva, Chenjian Li, Joseph M. Pilewski, Jason Callio, Charleen T. Chu, Anuradha Ray, Prabir Ray, Yulia Y. Tyurina, Valerian E. Kagan, Rama K. Mallampalli   +19 more
doaj   +1 more source