Results 141 to 150 of about 1,516,904 (247)

Isolated Bilateral Nephromegaly as the Initial Presentation of Acute Lymphoblastic Leukaemia: A Rare Case and Review of the Literature. [PDF]

Eur J Case Rep Intern Med
Hamdan R, Musleh M, Alhamadeh Alswij M, Ibraheem Y, Laflouf M, Mohamed Alyousef A.   +5 more
europepmc   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

Central nervous system involvement and relapse in adult acute lymphoblastic leukaemia-a population-based analysis in 2007-2022. [PDF]

Br J Haematol
Boberg E, Lübking A, Lennmyr EB, Dietrich CE, Joelsson J, Smedby KE, Wästerlid T, Hallböök H.   +7 more
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Identification of GSE1 as a PAX5 fusion partner and characterization of PAX5 fusion signature in B-cell acute lymphoblastic leukaemia. [PDF]

Br J Haematol
Wang H, Xue J, Yan W, Gao Y, Zong X, Zhou D, Huang D, Liu H, Zhang X, Yan J.   +9 more
europepmc   +1 more source

Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia [PDF]

, 2013
Blair, Allison, Moppett, John P, Diamanti, Paraskevi, Cox, Charlotte V   +3 more
core   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

Transplantation outcomes in patients with Down syndrome-associated acute lymphoblastic leukaemia: Implications for treatment intensity and the use of novel therapies. [PDF]

Br J Haematol
Ishida H, Okamoto Y, Sakaguchi H, Arai Y, Ueda T, Yamamoto S, Yano M, Yokosuka T, Okada K, Sato M, Karakawa S, Kobayashi R, Kato K, Koh K, Fujiki T, Goi K, Saito S, Takita J, Miyamura T, Koga Y, Yoshida N, Sato A, Hino M, Tabuchi K, Arakawa Y.   +24 more
europepmc   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Selumetinib as an Effective Therapy of Histiocytic Sarcoma Evolving From a B-Cell Acute Lymphoblastic Leukaemia. [PDF]

EJHaem
Largeaud L, Syrykh C, Vial J, Canali A, Luquet I, Vergez F, Dufrechou S, Prade N, Baruchel A, Gerby B, Nolla M, Delabesse E, Pasquet M.   +12 more
europepmc   +1 more source