Results 11 to 20 of about 1,516,904 (247)

The role of homeobox gene in leukaemia [PDF]

open access: yes, 2013
This thesis was submitted for the degree of Master of Philosophy and was awarded by Brunel UniversityHomeobox genes are known to be active during development and they are turned off after the early stages of developmental life.
Alshehri, Areej
core   +7 more sources

Childhood leukaemia: long-term excess mortality and the proportion 'cured'. [PDF]

open access: yes, 2008
Survival from childhood leukaemia has increased, but the proportion of children cured is unknown. The proportion 'cured' is defined as the proportion of survivors for whom, as a group, there is no longer excess mortality compared to the general ...
Shah, A.   +21 more
core   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

open access: yesHepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan   +19 more
wiley   +1 more source

Obesity and metabolic syndrome in adolescent survivors of standard risk childhood acute lymphoblastic leukemia in Saudi Arabia [PDF]

open access: yes, 2012
This study estimated prevalence of unhealthy weight status and metabolic syndrome (MS) amongst Saudi survivors of standard risk ALL. Procedure. We recruited 56 survivors, mean age 13.4 years (SD 4.1), a mean of 9.1 years (SD 4.1) postdiagnosis.
Aldhafiri, Fahad   +5 more
core   +4 more sources

Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia [PDF]

open access: yes, 2015
Although children with acute lymphoblastic leukemia (ALL) generally have a good outcome, some patients do relapse and survival following relapse is poor.
Mitchell, Chris D   +41 more
core   +1 more source

Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients

open access: yesActa Dermato-Venereologica, 2022
Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time.
Hwa Jung Yook   +8 more
doaj   +1 more source

Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia

open access: yesHaematologica, 2011
Acute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms ...
Amy L. Sherborne   +35 more
doaj   +1 more source

Severe L-asparaginase-induced Hypertriglyceridaemia Treated with Plasmapheresis

open access: yesEuropean Journal of Case Reports in Internal Medicine, 2021
L-asparaginase is used for the treatment of acute lymphoblastic leukaemia. Hypertriglyceridaemia is a side effect and associated with potentially fatal complications, including acute pancreatitis.
José Silvano   +3 more
doaj   +1 more source

Intrinsic and extrinsic apoptosis responses in leukaemia cells following daunorubicin treatment

open access: yesBMC Cancer, 2021
Background Daunorubicin is used clinically in the treatment of myeloma, acute lymphatic and myelocytic leukaemia. The toxic lesions caused by daunorubicin induce various modes of cell death, including apoptosis.
Hussain Mubarak Al-Aamri   +3 more
doaj   +1 more source

Immunotherapy in leukaemia

open access: yesActa Biochimica et Biophysica Sinica, 2023
Leukaemia is the common name for a group of malignant diseases of the haematopoietic system with complex classifications and characteristics. Remarkable progress has been made in basic research and preclinical studies for acute leukaemia compared to that
Mu Xingmei   +7 more
doaj   +1 more source

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