Results 41 to 50 of about 1,516,904 (247)

High-Resolution Genome-Wide Single Nucleotide Polymorphism Mapping in Acute Myeloid Leukaemia [PDF]

, 2008
PhDInvestigation of the genetics of acute myeloid leukaemia (AML) has revealed the underlying basis of the disease and led to targets for therapy. High-resolution single nucleotide polymorphism (SNP) arrays detected regions of loss of heterozygosity ...
Raghavan, Manoj
core   +4 more sources

Stenotrophomonas Maltophilia/S. Maltophilia Sepsis Presenting with Perianal Cellulitis and Pneumonia in a Leukemic Child

Journal of Pediatric Research, 2018
Infections caused by Stenotrophomonas maltophilia may be fatal in diseases such as leukaemia which causes immunodeficiency. Herein, we report a rare case of 8-year-old girl with acute lymphoblastic leukaemia, who developed perianal cellulitis and ...
Zeynep Canan Özdemir, Ayşe Bozkurt Turhan, Özcan Bör   +2 more
doaj   +1 more source

Detection and analysis of tumour biomarkers to strengthen the diagnosis of acute and chronic leukaemias

Revista Médica del Hospital General de México, 2015
Molecular markers in leukaemia are essential to diagnose, establish prognosis factors and determine the correct treatment of patients; therefore, it is imperative to include molecular biology studies, so that, combined with cytomorphology and ...
R. Cerón-Maldonado, A. Martínez-Tovar, C.O. Ramos-Peñafiel, E. Miranda-Peralta, I. Mendoza-Salas, E. Mendoza-García, E. Rozen-Fuller, J.J. Kassack-Ipiña, J. Collazo-Jaloma, A. Martínez-Herrera, I. Olarte-Carrillo   +10 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Selective targeting of NOTCH-1 for therapeutic purposes in xenograft models of T-acute lymphoblastic leukemia [PDF]

, 2013
T-cell acute lymphoblastic leukemia (T-ALL) is an heterogeneous disease, characterized by several genetic alterations and polymorphic clinical features both in children and adults.
Agnusdei, Valentina
core  

A novel three-colour fluorescence in situ hybridization approach for the detection of t(7;12)(q36;p13) in acute myeloid leukaemia reveals new cryptic three way translocation t(7;12;16) [PDF]

, 2013
© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).The t(7;12)(q36;p13 ...
Vetter, M, Sabrina Tosi, Plekhanova, O, Fleischman, E, Grigory Tsaur, Tsaur, G, Harbott, J, Sokova, O, Jochen Harbott, Tosi, S, Elena Fleischman, Olga Sokova, Naiel, A, Michael Vetter, Olga Plekhanova, Abdulbasit Naiel   +15 more
core   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Down syndrome-associated leukaemias: current evidence and challenges

Therapeutic Advances in Hematology
Children with Down syndrome (DS) are at increased risk of developing haematological malignancies, in particular acute megakaryoblastic leukaemia and acute lymphoblastic leukaemia.
Nicola R. Mason, Hilary Cahill, Yonatan Diamond, Karen McCleary, Rishi S. Kotecha, Glenn M. Marshall, Marion K. Mateos   +6 more
doaj   +1 more source

Key environmental stress biomarker candidates for the optimisation of chemotherapy treatment of leukaemia [PDF]

, 2014
The impact of fluctuations of environmental parameters such as oxygen and starvation on the evolution of leukaemia is analysed in the current review.
Pefani, Eleni, Pistikopoulos, Efstratios N., Brito Dos Santos, Susana, Misener, Ruth, Mantalaris, Athanasios, Velliou, Eirini G., Panoskaltsis, Nicki, Fuentes-Garí, Maria   +7 more
core   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source