Results 1 to 10 of about 264,861 (313)

Treatment of Central Nervous System Relapse in Acute Promyelocytic Leukemia by Venetoclax: A Case Report

Frontiers in Oncology, 2021
Extramedullary relapse of acute promyelocytic leukemia is a rare phenomenon and is associated with a poor prognosis, with the central nervous system being the most common site of relapse. The current treatments are still limited.
Xuzhao Zhang, Jinliang Chen, Weiqin Wang, Xian Li, Yanbin Tan, Xiaohong Zhang, Wenbin Qian   +6 more
doaj   +2 more sources

Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism

Haematologica, 2020
Obesity correlates with hematologic malignancies including leukemias, but risk of specific leukemia subtypes like acute promyelocytic leukemia and underlying molecular mechanisms are poorly understood.
Luca Mazzarella, Edoardo Botteri, Anthony Matthews, Elena Gatti, Davide Di Salvatore, Vincenzo Bagnardi, Massimo Breccia, Pau Montesinos, Teresa Bernal, Cristina Gil, Timothy J Ley, Miguel Sanz, Krishnan Bhaskaran, Francesco Lo Coco, Pier Giuseppe Pelicci   +14 more
doaj   +2 more sources

Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives

OncoTargets and Therapy, 2017
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) with a unique morphological appearance, associated coagulopathy and canonical balanced translocation of genetic material between chromosomes 15 and 17. APL was first
Derek McCulloch, Christina Brown, Harry Iland   +2 more
openalex   +3 more sources

Arsenic trioxide is required in the treatment of newly diagnosed acute promyelocytic leukemia. Analysis of a randomized trial (APL 2006) by the French Belgian Swiss APL group

Haematologica, 2018
In standard-risk acute promyelocytic leukemia, recent results have shown that all-trans retinoic acid plus arsenic trioxide combinations are at least as effective as classical all-trans retinoic acid plus anthracycline-based chemotherapy while being less
Lionel Adès, Xavier Thomas, Agnes Guerci Bresler, Emmanuel Raffoux, Olivier Spertini, Norbert Vey, Tony Marchand, Christian Récher, Arnaud Pigneux, Stephane Girault, Eric Deconinck, Claude Gardin, Olivier Tournilhac, Jean Francois Lambert, Patrice Chevallier, Stephane de Botton, Julie Lejeune, Hervé Dombret, Sylvie Chevret, Pierre Fenaux   +19 more
doaj   +2 more sources

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia [PDF]

Haematology and blood transfusion, 1988
Meng‐Er Huang, YC Ye, SR Chen, JR Chai, JX Lu, L Zhoa, LJ Gu, ZY Wang   +7 more
openalex   +2 more sources

Acute Promyelocytic Leukemia [PDF]

Cancers, 2020
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion between the promyelocytic leukemia (PML) gene and retinoic acid receptor-α (RARα) [...]
Xavier Thomas, Maël Heiblig
  +6 more sources

Current management of newly diagnosed acute promyelocytic leukemia [PDF]

Annals of Oncology, 2016
Laura Cicconi, Francesco Lo‐Coco
openalex   +2 more sources

Acute promyelocytic leukemia current treatment algorithms

Blood Cancer Journal, 2021
In 1957, Hillestad et al. defined acute promyelocytic leukemia (APL) for the first time in the literature as a distinct type of acute myeloid leukemia (AML) with a “rapid downhill course” characterized with a severe bleeding tendency. APL, accounting for
M. Yilmaz, H. Kantarjian, F. Ravandi
semanticscholar   +1 more source

Acute Promyelocytic Leukemia Presenting With a Myeloid Sarcoma of the Spine: A Case Report and Literature Review

Frontiers in Oncology, 2022
Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. Certain known acute myeloid leukemia cytogenetic abnormalities, in particular t(8,21), has been associated with a higher incidence.
Xuemei Shu, Qiuling Wu, Tao Guo, Hua Yin, Jingdi Liu   +4 more
doaj   +1 more source

Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears

BMC Cancer, 2022
Acute promyelocytic leukemia (APL) is considered a hematologic emergency due to high risk of bleeding and fatal hemorrhages being a major cause of death.
Jan-Niklas Eckardt, T. Schmittmann, S. Riechert, M. Kramer, A. S. Sulaiman, K. Sockel, F. Kroschinsky, J. Schetelig, Lisa Wagenführ, U. Schuler, U. Platzbecker, C. Thiede, F. Stölzel, C. Röllig, M. Bornhäuser, K. Wendt, J. Middeke   +16 more
semanticscholar   +1 more source