Results 41 to 50 of about 264,861 (313)

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA

Haematologica, 2016
The PML/RARA fusion protein occurs as a result of the t(15;17) translocation in the acute promyelocytic leukemia subtype of human acute myeloid leukemia.
Karen Keeshan, Pauline Vieugué, Shahzya Chaudhury, Loveena Rishi, Coline Gaillard, Lu Liang, Elaine Garcia, Takuro Nakamura, Nader Omidvar, Scott C. Kogan   +9 more
doaj   +1 more source

Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment Strategies

Cancers, 2019
This review highlights new findings that have deepened our understanding of the mechanisms of leukemogenesis, therapy and resistance in acute promyelocytic leukemia (APL).
N. Noguera, Gianfranco Catalano, C. Banella, M. Divona, I. Faraoni, T. Ottone, William Arcese, M. Voso   +7 more
semanticscholar   +1 more source

Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Braun, S., Duell, T., Gerhartz, Helmut Heinrich, Mittermueller, J., Schmetzer, Helga Maria, Wiesner, D.   +5 more
core   +1 more source

Acute promyelocytic leukemia (APL): remaining challenges towards a cure for all

Leukemia and Lymphoma, 2019
The application of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has revolutionized the treatment of acute promyelocytic leukemia (APL). More than 80–90% of patients are expected to be cured with a combination of ATRA, ATO and/or chemotherapy.
M. Stahl, M. Tallman
semanticscholar   +1 more source

FLT3 Length Mutations as Marker for Follow-Up Studies in Acute Myeloid Leukaemia [PDF]

, 2004
Length mutations within the FLT3 gene (FLT3-LM) can be found in 23% of acute myeloid leukaemia (AML) and thus are the most frequent mutations in AML. FLT3-LM are highly correlated with AML with normal karyotype and other cytogenetic aberrations of the ...
Haferlach, Torsten, Hiddemann, Wolfgang, Kern, Wolfgang, Schnittger, Susanne, Schoch, Claudia   +4 more
core   +1 more source

Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells [PDF]

, 2019
In this work, we have exploited the unique properties of a chimeric archaeal-human ferritin to encapsulate, deliver and release cytochrome c and induce apoptosis in a myeloid leukemia cell line.
Baiocco, P., Boffi, A., Bonamore, A., Fazi, F., Macone, A., Masciarelli, S., Palombarini, Federica, Quaglio, D., Trabuco, M. C.   +8 more
core   +2 more sources

Treatment advances have not improved the early death rate in acute promyelocytic leukemia

Haematologica, 2012
Early mortality in acute promyelocytic leukemia has been reported to occur in less than 10% of patients treated in clinical trials. This study reports the incidence and clinical features of acute promyelocytic leukemia patients treated at Stanford ...
James Scott McClellan, Holbrook E. Kohrt, Steven Coutre, Jason R. Gotlib, Ravindra Majeti, Ash A. Alizadeh, Bruno C. Medeiros   +6 more
doaj   +1 more source

Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]

, 2017
Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo, Ana Cañete, Arguello, Cardoso, Dary, De Luca, Elena Cano, Gebremedhin, Gerster, Grande, Guo, Haussler, Kuwata, Lo-Coco, McLaren, Nervi, North, Ottersbach, O’Donnell, Ramón Muñoz-Chápuli, Rita Carmona, Ross, Testa, West   +23 more
core   +4 more sources

A giant thrombus in the right atrium of a patient with acute promyelocytic leukemia M3

Radiology Case Reports, 2023
Acute promyelocytic leukemia is a special type of acute myeloid leukemia. Patients with this disease are at high risk of complications. Right atrial thrombosis is a rare but potentially serious complication.
Pham Ngoc Thach, MD, Ho Tran Ban, MD, Huynh-Thi Vu Quynh, MD, Tran-Thi Thanh, MD, Phan Thao Nguyen, MD, Trinh Nguyen Ha Vi, MD, Tran Ba Hieu, MD, Nguyen Duc Chinh, MD, Tran Hoa, MD, Bui The Dung, MD, Nguyen Minh Duc, MD   +10 more
doaj   +1 more source

Acute Promyelocytic Leukemia: A History over 60 Years—From the Most Malignant to the most Curable Form of Acute Leukemia

Oncology and Therapy, 2019
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) that is cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion of the promyelocytic ...
X. Thomas
semanticscholar   +1 more source