Results 181 to 190 of about 7,722 (194)

Monoallelic variants in ACVR1 in a cohort of Egyptian individuals with fibrodysplasia ossificans progressiva

Clinical Dysmorphology
Objectives Fibrodysplasia ossificans progressiva (FOP) is a rare ectopic ossification disorder of connective tissue deposited in the muscles, fascia, tendons, and ligaments.
R. Elhossini, H. El-Bassyouni, E. Ashaat, A. Ashour, Khaled Hamed, D. R. Soliman, Ibrahim M Hegazy, Sawsan Abdel-Hadi, H. Elbendary, M. Mehrez, N. Hassib, M. A. Al Kersh, A. Othman, G. Abdel-Salam, Mohamed S. Abdel-Hamid, M. Aglan   +15 more
semanticscholar   +1 more source

Pro-tumor Macrophage Polarization Mediated by BMP2/4-ACVR1 Signaling Orchestrates an Immunosuppressive Microenvironment During Tumor Initiation.

Cancer Research
Cancer cells are able to evade immune surveillance by engendering an immunosuppressive "cold" tumor microenvironment (cTME). A better understanding of the mechanisms underlying the establishment of a cTME in the initial phases of tumor formation could ...
Mingchao Wang, Zhihong Song, Hao Yuan, Chang Liu, Wei Wang, Naixue Yang, Keyong Sun, Shanshan Zhang, Xianhan Qin, Jingwei Li, Chen Tian, Runda Xu, Yixin Huang, Shicheng Hu, X. Nie, Zhixin Bie, Xinquan Liu, Yi Yao, Xin Lin, Chunhua Lin, Xun Lan   +20 more
semanticscholar   +1 more source

Multi-omics therapeutic perspective on ACVR1 gene: from genetic alterations to potential targeting.

Briefings in Functional Genomics, 2022
Activin A receptor type I (ACVR1), a transmembrane serine/threonine kinase, belongs to the transforming growth factor-β superfamily, which signals via phosphorylating the downstream effectors and SMAD transcription factors.
Garima C. Nagar, Pooja Mittal, Shradheya R. R. Gupta, Monika Pahuja, Manisha Sanger, R. Mishra, Ashutosh Kumar Singh, I. Singh   +7 more
semanticscholar   +1 more source

ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation.

Cellular Signalling
Tubulointerstitial fibrosis in the kidneys is a chronic and progressive process. Although studies suggested that tubular epithelial-mesenchymal transition (EMT) plays a key role in the development of kidney fibrosis, whether ACVR1, a member of the TGFβ ...
Tianli Yu, Zhangyu Mai, Shunhui Zhang, Shunyi Wang, Wenjin Yang, Zhang Ruan, Pi Li, Fujia Guo, Yining Zhang, Jiangchao Li, Lijing Wang, Caixia Lin, Lingyun Zheng   +12 more
semanticscholar   +1 more source

Bta-miR-301a targets ACVR1 to influence cleavage time and blastocyst formation rate of early embryos in cattle

Biology of Reproduction
Accumulating evidence indicates that paternally derived microRNAs play a crucial role in the development of early embryos and are regarded as the key factor in the successful development of somatic cell cloned embryos. In our previous study, bta-miR-301a
Heqiang Li, Jing Gao, Jingyi Wang, Baobao Zhao, Xiaonan Ma, Bihan Zhang, C. Lv, Hailian Qiao, Yongsheng Wang, S. Qing   +9 more
semanticscholar   +1 more source

Unlocking the Door for Precision Medicine in Rare Conditions: Structural and Functional Consequences of Missense ACVR1 Variants

Omics
Rare diseases and conditions have thus far received relatively less attention in the field of precision/personalized medicine than common chronic diseases.
Garima Nagar, Shradheya R. R. Gupta, Vanshika Rustagi, R. K. Pramod, Archana Singh, Monika Pahuja, I. Singh   +6 more
semanticscholar   +1 more source

Corrigendum to "Design of primers for direct sequencing of nine coding exons in the human ACVR1 gene" [Bone 138 (2020) 115469].

Bone, 2023
Masaru Matsuoka, S. Tsukamoto, Yuta Orihara, R. Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri   +7 more
semanticscholar   +1 more source

Morpholino-Mediated Exon Skipping Targeting Human ACVR1/ALK2 for Fibrodysplasia Ossificans Progressiva.

Methods in molecular biology
R. Maruyama, T. Yokota
semanticscholar   +1 more source

Recurrent ACVR1 mutations in posterior fossa ependymoma

Acta Neuropathologica, 2022
D. Pratt, C. Lucas, Pavalan Selvam, Zied Abdullaev, Courtney Ketchum, Martha Quezado, T. Armstrong, M. Gilbert, A. Papanicolau‐Sengos, M. Raffeld, Hyoyoung Choo-Wosoba, Priya P. Chan, Nicholas S Whipple, M. Nasrallah, M. Santi, V. Ramaswamy, C. Giannini, Timothy A. Ritzmann, R. Grundy, A. Burford, Chris Jones, C. Hawkins, S. Venneti, D. Solomon, Kenneth D. Aldape   +24 more
semanticscholar   +1 more source

POSTER: MDS-380 ACVR1 Expression in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia Based on Response to Hypomethylating Agents

Clinical Lymphoma, Myeloma & Leukemia
Yue Wei, J. Rodriguez-Sevilla, N. Short, G. Bravo, K. Sasaki, A. Bataller, A. Bazinet, I. Bouligny, Hui Yang, H. Kantarjian, G. Garcia-Manero, K. Chien   +11 more
semanticscholar   +1 more source