Results 21 to 30 of about 7,722 (194)

Global Gene Expression Profiling of Individual Human Oocytes and Embryos Demonstrates Heterogeneity in Early Development [PDF]

, 2013
Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals.
Brison, Daniel R., Kimber, Susan J., Shaw, Lisa, Sneddon, Sharon F., Zeef, Leo   +4 more
core   +13 more sources

Momelotinib (JAK1/JAK2/ACVR1 inhibitor): mechanism of action, clinical trial reports, and therapeutic prospects beyond myelofibrosis

Haematologica, 2023
Janus kinase (JAK) 2 inhibitors are now part of the therapeutic armamentarium for primary and secondary myelofibrosis (MF). Patients with MF endure shortened survival and poor quality of life.
A. Tefferi, A. Pardanani, N. Gangat
semanticscholar   +1 more source

Fibrodysplasia ossificans progressiva: current concepts from bench to bedside

Disease Models & Mechanisms, 2020
Heterotopic ossification (HO) is a disorder characterised by the formation of ectopic bone in soft tissue. Acquired HO typically occurs in response to trauma and is relatively common, yet its aetiology remains poorly understood.
Arun-Kumar Kaliya-Perumal, Tom J. Carney, Philip W. Ingham   +2 more
doaj   +1 more source

Revision Distal Bicep Repair in the Setting of Heterotopic Ossification: Case Study. [PDF]

Clin Case Rep
Radiographic and intraoperative findings demonstrating heterotopic ossification following distal biceps tendon repair. ABSTRACT Heterotopic ossification (HO) following distal biceps tendon repair is an uncommon but potential complication. This may present pain, limited range of motion, or sensory changes due to nerve compression.
Brikho AM, Abbo JJ, Yousif MJ.
europepmc   +2 more sources

High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. [PDF]

, 2015
Human genome-wide association studies have identified thousands of loci associated with disease phenotypes. Genome-wide association studies also have become feasible using rodent models and these have some important advantages over human studies ...
Churchill, Gary A, Eskin, Eleazar, Lusis, Aldons J, Parks, Brian, Rau, Christoph D, Simecek, Petr, Wang, Yibin   +6 more
core   +1 more source

MicroRNA-483 amelioration of experimental pulmonary hypertension. [PDF]

, 2020
Endothelial dysfunction is critically involved in the pathogenesis of pulmonary arterial hypertension (PAH) and that exogenously administered microRNA may be of therapeutic benefit.
Bai, Liang, Chen, Shanshan, Chou, Chih-Hung, Cui, Xiaopei, Fan, Fenling, Gongol, Brendan, Gu, Mingxia, He, Ming, He, Yangyang, Huang, Hsien-Da, Jing, Zhi-Cheng, Lei, Yuyang, Li, Zhao, Malhotra, Atul, Miao, Yifei, Rabinovitch, Marlene, Shen, Yuan, Shyy, John Y-J, Wang, Xiaojian, Yan, Xiaosong, Zhang, Jiao, Zhang, Jin, Zhang, Yixin   +22 more
core   +1 more source

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

eLife, 2021
Abnormalities in skeletal muscle repair can lead to poor function and complications such as scarring or heterotopic ossification (HO). Here, we use fibrodysplasia ossificans progressiva (FOP), a disease of progressive HO caused by ACVR1R206H (Activin ...
Emilie Barruet, Steven M Garcia, Jake Wu, Blanca M Morales, Stanley Tamaki, Tania Moody, Jason H Pomerantz, Edward C Hsiao   +7 more
doaj   +1 more source

Influence on proliferation and apoptosis of intestinal epithelial cells and expression of ACVR1 by Helicobacter pylori

European Journal of Inflammation, 2021
To discuss the influence on proliferation and apoptosis of human intestinal epithelial cells by Helicobacter pylori (Hp). CCK-8 method and flow cytometry to test the influence on proliferation and apoptosis of intestinal epithelial cells by Hp and cell ...
Yunfeng Lin, Min Chen, Shuyu Zhang, Zhichun Feng, Jingwen Wang   +4 more
doaj   +1 more source

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]

, 2015
BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi, Bauer, Jessica, Carroll, Timothy, Eckmann, Lars, Grippo, Paul J, Jung, Barbara, Ozden, Ozkan, Principe, Daniel R, Spehlmann, Martina E, Staudacher, Jonas J   +9 more
core   +2 more sources

ACVR1: A Novel Therapeutic Target to Treat Anemia in Myelofibrosis

Cancers, 2023
Simple Summary The human activin receptor type I (ACVR1) is a complex protein that regulates production of hepcidin on hepatocytes and red blood cells. Hepcidin is a small peptide that regulates iron metabolism and plasma iron levels.
A. Duminuco, H. Chifotides, S. Giallongo, C. Giallongo, D. Tibullo, G. A. Palumbo   +5 more
semanticscholar   +1 more source