Results 61 to 70 of about 7,648 (236)

The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens

Disease Models & Mechanisms, 2011
SUMMARY We previously found that lenses lacking the Acvr1 gene, which encodes a bone morphogenetic protein (BMP) receptor, had abnormal proliferation and cell death in epithelial and cortical fiber cells.
Luke A. Wiley, Ramya Rajagopal, Lisa K. Dattilo, David C. Beebe   +3 more
doaj   +1 more source

MicroRNA bta-miR-365-3p inhibits proliferation but promotes differentiation of primary bovine myoblasts by targeting the activin A receptor type I

Journal of Animal Science and Biotechnology, 2021
Background MicroRNAs act as post-transcriptional regulators that repress translation or degrade mRNA transcripts. Each microRNA has many mRNA targets and each mRNA may be targeted by several microRNAs.
Dan Hao, Xiaogang Wang, Xiao Wang, Bo Thomsen, Yu Yang, Xianyong Lan, Yongzhen Huang, Hong Chen   +7 more
doaj   +1 more source

BMP signaling in telencephalic neural cell specification and maturation [PDF]

, 2016
Bone morphogenetic proteins (BMPs) make up a family of morphogens that are critical for patterning, development, and function of the central and peripheral nervous system.
Gamez Molina, Beatriz, Rodríguez Carballo, Edgardo, Ventura Pujol, Francesc   +2 more
core   +1 more source

S249: SELECTIVE JAK2/IRAK1/ACVR1 INHIBITOR PACRITINIB BEFORE REDUCED-INTENSITY CONDITIONING ALLOGENEIC STEM CELL TRANSPLANTATION IN MYELOFIBROSIS: FINAL ANALYSIS OF THE PHASE II HOVON-134 TRIAL

HemaSphere, 2023
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Ruben Van Dijck, Ron VAN DER Holt, E. Meijer, T. Devos, M. Hazenberg, M. V. D. van der Poel, D. Breems, L. Deleu, N. Schaap, Peter André Willem Te Boekhorst   +9 more
semanticscholar   +1 more source

ACVR1 mutation and Fibrodysplasia Ossificans Progressiva in Chinese children [PDF]

Pediatric Rheumatology, 2011
Fibrodysplasia Ossificans Progressiva (FOP) is a rare autosomal dominant connective tissue disorder characterized by congenital great toes malformation and progressive heterotopic osteogenesis leading to progressive debilitating ankylosis of the body.
Ng Bobby KW, Liu KL, Chan KH, Hui Joannie, Ho Assunta CH, Lo Ivan FM, Lam STS   +6 more
openaire   +2 more sources

Cross-talk among AFAP1-AS1, ACVR1 and microRNA-384 regulates the stemness of pancreatic cancer cells and tumorigenicity in nude mice

Journal of Experimental & Clinical Cancer Research, 2019
Background Pancreatic cancer (PC) represents one of the most aggressive forms of cancer. The role of long non-coding RNAs (lncRNAs) has been highlighted in various malignancies including PC.
Xu-Bo Wu, Xia Feng, Qi-Meng Chang, Cheng-Wu Zhang, Zhi-Fei Wang, Jie Liu, Zhi-Qiu Hu, Jia-Zhe Liu, Wei-Ding Wu, Zi-Ping Zhang, Xi-Qiang Liu   +10 more
doaj   +1 more source

ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans

Pain, 2022
Supplemental Digital Content is Available in the Text. An ACVR1 activating mutation causes heat and mechanical pain hypersensitivity and induces sensory neuron hyperexcitability in humans.
Xiaobing Yu, A. Ton, Zejun Niu, Blanca M. Morales, Jiadong Chen, J. Braz, M. H. Lai, Emilie Barruet, Hongju Liu, K. Cheung, S. Ali, Tea Chan, K. Bigay, Jennifer Ho, Ina Nikolli, S. Hansberry, K. Wentworth, A. Kriegstein, A. Basbaum, E. Hsiao   +19 more
semanticscholar   +1 more source

Twists in the fibrodysplasia ossificans progressiva story challenge and expand our understanding of BMP biology

The Journal of Clinical Investigation, 2022
Fibrodysplasia ossificans progressiva (FOP) is an ultrarare, debilitating disease in which heterotopic bone is formed in certain soft tissues. A gain-of-function variant in the cytoplasmic domain of the activin A receptor type I (ACVR1) exists in all ...
Michael T. Collins
doaj   +1 more source

Atypical Presentation and Management of Fibrodysplasia Ossificans Progressiva [PDF]

, 2017
We report a case of an 18-year-old woman, with bilateral acute inflammatory pain on the hip area, during the premenstrual period, and progressive increase in volume and rigidity of both hips. Bilateral exuberant soft tissue calcifications were present on
Arcângelo, J, Grenho, A, Martins, A
core   +1 more source

Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes)

PLoS ONE, 2023
Activin and Bone Morphogenetic Protein (BMP) signaling plays crucial roles in vertebrate organ formation, including osteo- and angiogenesis, and tissue homeostasis, such as neuronal maintenance.
M. Trumpp, W. H. Tan, Wiktor Burdzinski, Yara Basler, Jerome Jatzlau, Petra Knaus, Christoph Winkler   +6 more
semanticscholar   +1 more source