Results 81 to 90 of about 7,722 (194)

Population Pharmacokinetics and Exposure–Response Analyses of Momelotinib, Its Active Metabolite (M21), and Total Active Moiety in Myelofibrosis

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 629-640, March 2026.
Momelotinib, a Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor, is approved for the treatment of myelofibrosis with anemia. These analyses characterized the population pharmacokinetics of momelotinib and its active metabolite M21 following administration of the commercial tablet formulation in patients with myelofibrosis from phase II/III
Benjamin Rich, Meenakshi Srinivasan, Yu Liu Ho, Sandra A.G. Visser, Geraldine Ferron‐Brady, Georgios Vlasakakis   +5 more
wiley   +1 more source

Development of the SIOPE DIPG network, registry and imaging repository : a collaborative effort to optimize research into a rare and lethal disease [PDF]

, 2017
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival.
Bailey, S, Barkhof, F, Baugh, J, Biassoni, V, Bison, B, Calmon, R, Cannarozzo, A, Castel, D, Chaney, B, Colditz, N, Cruz, O, Damen-Korbijn, CM, De Jongh, D, De Wolf, R, Deak, L, Emmerik, J, Entz-Werle, N, Fouladi, M, Gandola, L, Garami, M, Gerber, N, Gielen, GH, Gil-da-Costa, MJ, Giraud, G, Grill, J, Grundy, R, Hargrave, DR, Hauser, P, Hayden, T, Hoffmann, M, Holm, S, Hulleman, E, Jacobs, S, Jadrijevic-Cvrlje, F, Janssens, GO, Jones, C, Jones, DT, Kaspers, GJ, Kattamis, A, Kebudi, R, Kitanovski, L, Kivivuori, SM, Kramm, CM, Leblond, P, Lieverst, JA, Lopez-Aguilar, E, Massimino, M, members of the SIOPE DIPG Network, ., Morales La Madrid, A, Noltes, J, Nysom, K, Pears, J, Pentikainen, V, Perek-Polnik, M, Rutkauskiene, G, Sanchez Aliaga, E, Shats, L, Slavc, I, Sturm, D, Sumerauer, D, Thorarinsdottir, HK, Torsvik, IK, Van Dijk, J, Van Gool, S, van Vuurden, DG, Vandertop, WP, Varlet, P, Veldhuijzen van Zanten, SE, von Bueren, AO, Warmuth-Metz, M, Zapata-Tarres, M, Zheludkova, O   +71 more
core   +5 more sources

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
This study shows that the blood‐derived molecule, Fibrinogen, has a differential effect on human Oligodendroglial (OL) cells. Fibrinogen, when added in vitro, leads to aberrant differentiation of OL‐precursors towards an astrocytic fate. On the other hand, when added into the culture of mature OLs, fibrinogen increases myelination capacity.
Gabriela J. Blaszczyk, Chao Weng, Abdulshakour Mohammadnia, Qiao‐Ling Cui, Arianna Giurleo, Adam M. R. Groh, Chloe Plouffe, Julien Sirois, Valerio E. C. Piscopo, Moein Yaqubi, Asad Taqvi, Erin Cassidy, Liam Callahan Martin, Jeffery A. Hall, Roy W. R. Dudley, Myriam Srour, Stephanie E. J. Zandee, Wendy Klement, Sandra Larouche, Alexandre Prat, Thomas M. Durcan, Jo Anne Stratton, Jack P. Antel, G. R. Wayne Moore   +23 more
wiley   +1 more source

Fibrodysplasia ossificans progressiva with minor unilateral hallux anomaly in a sporadic case from Northern Tanzania with the common ACVR1c.617G A mutation

The Pan African Medical Journal, 2015
Fibrodysplasia ossificans progressiva is a rare autosomal dominantly inherited disorder of connective tissue caused by mutations in the gene encoding for ACVR1/ALK2, a bone morphogenetic protein type I receptor.
Mohammed Saleh, Joost Commandeur, Renata Bocciardi, Grace Kinabo, Ben Hamel   +4 more
doaj   +1 more source

A Transcriptomic Analysis of Cancer‐Stromal Interactome in Lung Cancer Xenograft Models

Cancer Science, Volume 117, Issue 3, Page 841-851, March 2026.
We conducted a comprehensive analysis of the lung cancer interactome to identify key ligand–receptor pairs involved in the aggressiveness of lung adenocarcinoma. Tumor necrosis factor superfamily member 12 and its receptor tumor necrosis factor receptor superfamily member 12A signaling axis may be potential candidates for therapeutic intervention for ...
Yuriko Takayama‐Isagawa, Daisuke Komura, Takayuki Isagawa, Yusuke Amano, Atsushi Kihara, Tamaki Miura, Taichiro Yoshimoto, Hiroyoshi Tsubochi, Kazutaka Fujita, Koichi Hagiwara, Makoto Maemondo, Tetsuo Ushiku, Shumpei Ishikawa, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara, Toshiro Niki   +16 more
wiley   +1 more source

Genetic variants in anti-Mullerian hormone and anti-Mullerian hormone receptor genes and breast cancer risk in Caucasians and African Americans [PDF]

, 2014
Anti-Mullerian hormone (AMH) regulates ovarian folliculogenesis by signaling via its receptors, and elevated serum AMH levels are associated with an increased risk of breast cancer. No previous studies have examined the effects of genetic variants in AMH-
Dorgan, Joanne F., Nan, Hongmei, Rebbeck, Timothy R.   +2 more
core  

Reduced GS domain serine/threonine requirements of Fibrodysplasia Ossificans Progressiva mutant type I BMP receptor ACVR1 in the zebrafish

bioRxiv, 2022
Fibrodysplasia ossificans progressiva (FOP) is a rare human genetic condition characterized by altered skeletal development and extra-skeletal bone formation.
Robyn S. Allen, W. D. Jones, Maya Hale, Bailey Warder, E. Shore, M. Mullins   +5 more
semanticscholar   +1 more source

Survival and quality‐of‐life implications of cytopenia trajectories in ruxolitinib‐treated myelofibrosis

Cancer, Volume 132, Issue 4, 15 February 2026.
Abstract Background Cytopenia is a common complication in patients with myelofibrosis and may worsen during treatment with ruxolitinib. Methods The RUX‐MF multicenter study evaluated 879 patients treated with ruxolitinib for at least 6 months, categorizing them into four groups based on the evolution of cytopenia: never cytopenic, treatment‐emergent ...
Francesca Palandri, Giovanni Caocci, Elisabetta Abruzzese, Mario Tiribelli, Erika Morsia, Mirko Farina, Giulia Benevolo, Eloise Beggiato, Bruno Martino, Novella Pugliese, Alessia Tieghi, Monica Crugnola, Gianni Binotto, Francesco Cavazzini, Alessandra Iurlo, Alessandro Isidori, Alessandra Dedola, Emilia Scalzulli, Andrea Duminuco, Daniele Cattaneo, Roberto M. Lemoli, Costanza Bosi, Daniela Cilloni, Monica Bocchia, Fabrizio Pane, Chiara Sartor, Florian H. Heidel, Massimo Breccia, Filippo Branzanti, Giuseppe A. Palumbo, Massimiliano Bonifacio, Elena M. Elli   +31 more
wiley   +1 more source

Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers

Scientific Reports, 2021
The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in ...
Eirini Tarsani, Andreas Kranis, Gerasimos Maniatis, Ariadne L. Hager-Theodorides, Antonios Kominakis   +4 more
doaj   +1 more source

The prognostic value and potential immunotherapeutic efficacy of ACVR1 in treating gastric cancer

Journal of Gastrointestinal Oncology
Background The discovery of biomarkers has facilitated the treatment of cancer. At present, the relationship between activin A receptor type-1 (ACVR1) and gastric cancer is gradually discovered.
Hui Zhang, Ruiqi Liu, Yanrong Chen, Ruicong Ma, Qiang Xue, Arvind Sahu, Xiaodi Yan, Hongmei Gu   +7 more
semanticscholar   +1 more source