Results 31 to 40 of about 30,581 (218)

Pseudoboehmite as a drug delivery system for acyclovir

Scientific Reports, 2021
Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital ...
Renato Meneghetti Peres, Jéssica Maiara Leme Sousa, Mariana Oliva de Oliveira, Maura Vincenza Rossi, Rene Ramos de Oliveira, Nelson Batista de Lima, Ayrton Bernussi, Juliusz Warzywoda, Bruno Sarmento, Antonio Hortencio Munhoz   +9 more
doaj   +1 more source

Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir

Pharmaceuticals, 2021
Conventional formulations of antiviral drug acyclovir have various limitations such as low bioavailability. The current study was aimed at developing polymeric matrices for the controlled delivery of acyclovir using sericin as polymer and acrylic acid ...
Moawia M. Al-Tabakha, Shujaat Ali Khan, Akram Ashames, Hamid Ullah, Kaleem Ullah, Ghulam Murtaza, Nageeb Hassan   +6 more
doaj   +1 more source

Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct

Journal of Neuroinflammation, 2010
Regulatory T cells, Tregs, are a subset of lymphocytes that have immunosuppressive attributes. They are elevated in blood of glioblastoma patients and within this tumor's tissue itself. Indoleamine 2,3-dioxygenase, IDO, converts tryptophan to kynurenine.
Söderlund Johan, Erhardt Sophie, Kast Richard E   +2 more
doaj   +1 more source

Acyclovir Nephrotoxicity: A Case Report Highlighting the Importance of Prevention, Detection, and Treatment of Acyclovir-Induced Nephropathy

Case Reports in Medicine, 2010
Acute kidney injury is an unfortunate complication of acyclovir therapy secondary to crystal-induced nephropathy. It is characterized by a decrease in renal function that develops within 24–48 hours of acyclovir administration indicated by a rapid rise ...
Raymond Fleischer, Michael Johnson
doaj   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics

Advanced Healthcare Materials, EarlyView.
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Herpes Simplex Virus Type 1 Clinical Isolates Respond to UL29-Targeted siRNA Swarm Treatment Independent of Their Acyclovir Sensitivity

Viruses, 2020
Acyclovir is the drug of choice for the treatment of herpes simplex virus (HSV) infections. Acyclovir-resistant HSV strains may emerge, especially during long-term drug use, and subsequently cause difficult-to-treat exacerbations. Previously, we set up a
Kiira Kalke, Jenni Lehtinen, Jelena Gnjatovic, Liisa M. Lund, Marie C. Nyman, Henrik Paavilainen, Julius Orpana, Tuomas Lasanen, Fanny Frejborg, Alesia A. Levanova, Tytti Vuorinen, Minna M. Poranen, Veijo Hukkanen   +12 more
doaj   +1 more source

Acyclovir in bipolar disorder: A mismatched combination?

Indian Journal of Psychological Medicine, 2011
Acyclovir, a commonly used antiviral drug can rarely result in neuropsychiatric complications especially in elderly. We for the first time report acyclovir associated hypomania in an elderly woman.
Naveen Jayaram, Naren P Rao, Ganesan Venkatasubramanian, S Sanmuganathan, Rishikesh V Behere, Shivaram Varambally, Bangalore N Gangadhar   +6 more
doaj   +1 more source

A Comparative Study to Evaluate the Efficacy and Safety of Acyclovir and Famciclovir in the Management of Herpes Zoster [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Over the years, acyclovir has been the oral antiviral agent approved for the treatment of patients with acute herpes zoster,Its effectiveness in lessening the acute signs and symptoms of herpes zoster has been established but the effects ...
M.G. GOPAL, SHANNOMA, SHARATH KUMAR B.C., RAMESH M., NANDINI A.S., NAMRATA C. MANJUNATH   +5 more
doaj   +1 more source

A simple method for the determination of acyclovir concentrations in human plasma using high-performance liquid chromatography

Future Journal of Pharmaceutical Sciences
Background Acyclovir is an anti-viral medication given to treat herpes simplex and herpes zoster infection. In some severe conditions such as herpes encephalitis, acyclovir is administered intravenously.
Asma Aboelezz, Maged Kharouba, Sherif Hanafy Mahmoud   +2 more
doaj   +1 more source