Results 131 to 140 of about 80,359 (315)

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

Advanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez, Maria Virginia Giolito, Sultan Al‐Siyabi, Kristian Serafimov, Florine Laloux, Emeline Dierge, Léo Aubert, Céline Guilbaud, Selena Kaye, Paula Varon, Dorothée Marchand, Hanne Vlieghe, Emmanuel Hermans, Caroline Bouzin, Davide Brusa, Christiani Andrade Amorim, Barabara Pachikian, Yvan Larondelle, Cyril Corbet, Chantal Dessy, Olivier Feron   +20 more
wiley   +1 more source

ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty Acids

Advanced Science, EarlyView.
This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin, Yulong Hong, Yongqi Zhao, Wensheng Shi, Ruilin Liu, Xinyu You, Chong Yang, Yu Zhang   +7 more
wiley   +1 more source

Acyl carrier protein. V. Identification of 4'-phosphopantetheine bound to a mammalian fatty acid synthetase preparation. [PDF]

, 1965
Allan R. Larrabee, E.G. McDaniel, Howard Bakerman, P. Roy Vagelos   +3 more
openalex   +1 more source

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

Advanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li, Xueying Li, Chunhong Liu, Zhenzhi Li, Kaixin Ding, Yuxin Wang, Ning Gu, Liwei Xie, Zheng Chen   +8 more
wiley   +1 more source

A Plasmodium LARC GAP provides preerythrocytic, stage and species transcending protection in mice

npj Vaccines
Malonyl-CoA-acyl carrier protein transacylase (MCAT) catalyzes the transfer of a malonyl moiety from malonyl–CoA to acyl carrier protein during the initiation step of type II fatty acid synthesis (FASII).
Raksha Devi, Rohini Nandi, Satish Mishra
doaj   +1 more source

Substrate Sequestration and Chain Flipping in Human Mitochondrial Acyl Carrier Protein. [PDF]

Biochemistry, 2023
Suo Y, Chen A, La Clair JJ, Burkart MD.
europepmc   +1 more source

Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat

Advanced Science, EarlyView.
Ruminant meat is widely appreciated for its distinctive flavor. Lipids play a central role in influencing meat flavor, yet their genetic and biochemical basis remains largely unexplored. Here, a comprehensive lipid genetic map of sheep muscle is constructed and 20 candidate genes potentially modulating lipid levels are identified to provide a roadmap ...
Xueying Zhang, Yuanyuan Kong, Jialei Chen, Ran Li, Zhongyu Wang, Yali Song, Tianshu Dai, Yuxin Fu, Beixiang Jiang, Jize Zeng, Shengwei Pei, Yangkai Liu, Qianjie Feng, Weiwei Fu, Zehu Yuan, Joram Mwashigadi Mwacharo, Fadi Li, Xiangpeng Yue   +17 more
wiley   +1 more source

Amide Chemistry Enables Redox Locking of Cyclic Disulfides for Polypeptide Assembly

Angewandte Chemie, EarlyView.
The stability of a family of cyclic dichalcogenides derived from cysteine is significantly enhanced against reductants upon acylation of the alpha‐amino group. Amide formation serves as a redox lock, offering a mechanism to achieve selectivity in the assembly of large cyclic polypeptides on a water‐compatible solid support.
Vincent Diemer, Eliott Roy, Benoît Snella, Frédéric Capet, Oleg Melnyk   +4 more
wiley   +2 more sources

POSTN‐Mediated Interplay of M1 Polarized Macrophage with Tendon‐Derived Stem Cells to Drive Traumatic Heterotopic Ossification Formation through PTK7/ATK Signaling?

Advanced Science, EarlyView.
The mechanism diagram reveals that the formation of trauma‐induced heterotopic ossification (HO) is accompanied by the polarization of macrophages toward the M1 phenotype. Additionally, the extracellular vesicles secreted by M1 macrophages, which contain periostin (POSTN), directly bind to PTK7 in tendon‐derived stem cells (TDSCs).
Hang Liu, Xinyue Li, Mengyi Li, Ziyang Sun, Xu Wang, Juehong Li, Binbin Xu, Qian Chen, Cunyi Fan, Hongjiang Ruan   +9 more
wiley   +1 more source

On‐Demand Photodegradable and Thermo‐Reversible, Soft, Transparent Dithioacetal Hydrogels

Angewandte Chemie, EarlyView.
A versatile chemical platform for the development of photodegradable and thermally–reversible hydrogels is presented. The hydrogels were synthesized via a step‐growth reaction of a difunctional PEG‐thiol with an aromatic dialdehyde cross‐linker. The photosensitive dithioacetal bonds endowed the material with photodegradable and thermo‐reversible ...
Maria Psarrou, Ioanna Chatzaki, Antonis Mavromanolakis, Theodore Manouras, Dimitris Vlassopoulos, Maria Vamvakaki   +5 more
wiley   +2 more sources