Results 11 to 20 of about 47,958 (242)

Interfacial Enzymes Enable Gram-Positive Microbes to Eat Fatty Acids

Membranes, 2023
Exogenous fatty acid (eFA) activation and utilization play key roles in bacterial physiology and confer growth advantages by bypassing the need to make fatty acids for lipid synthesis.
Christopher D. Radka
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A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis

Frontiers in Microbiology, 2022
The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li, Qian Huang, Weidi Zhang, Yinghua Cao, Zhanxin Wang, Zhenwen Zhao, Xiaotian Zhang, Junjie Zhang   +7 more
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Acyl Carrier Protein in Mycoplasmas [PDF]

Journal of Bacteriology, 1973
Acyl carrier protein (ACP) activity was determined by the malonyl-coenzyme A–CO 2 exchange reaction. It was highest in Acholeplasma laidlawii , lower in A. granularum , and lowest in A. axanthum . The sterol-requiring Mycoplasma
S, Rottem, O, Muhsam-Peled, S, Razin
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Acylation of the Type 3 Secretion System Translocon Using a Dedicated Acyl Carrier Protein. [PDF]

PLoS Genetics, 2017
Bacterial pathogens often deliver effectors into host cells using type 3 secretion systems (T3SS), the extremity of which forms a translocon that perforates the host plasma membrane.
Julie P Viala, Valérie Prima, Rémy Puppo, Rym Agrebi, Mickaël J Canestrari, Sabrina Lignon, Nicolas Chauvin, Stéphane Méresse, Tâm Mignot, Régine Lebrun, Emmanuelle Bouveret   +10 more
doaj   +1 more source

Involvement of Arabidopsis Acyl Carrier Protein 1 in PAMP-Triggered Immunity

Molecular Plant-Microbe Interactions, 2022
Plant fatty acids (FAs) and lipids are essential in storing energy and act as structural components for cell membranes and signaling molecules for plant growth and stress responses.
Zhenzhen Zhao, Jiangbo Fan, Piao Yang, Zonghua Wang, Stephen Obol Opiyo, David Mackey, Ye Xia   +6 more
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Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics [version 2; peer review: 2 approved]

F1000Research, 2022
Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics.
Vladyslav Yadrykhins'ky, Ruth Brenk, Charis Georgiou   +2 more
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Trapping of the Enoyl-Acyl Carrier Protein Reductase–Acyl Carrier Protein Interaction [PDF]

Journal of the American Chemical Society, 2016
An ideal target for metabolic engineering, fatty acid biosynthesis remains poorly understood on a molecular level. These carrier protein-dependent pathways require fundamental protein-protein interactions to guide reactivity and processivity, and their control has become one of the major hurdles in successfully adapting these biological machines.
Tallorin, Lorillee, Finzel, Kara, Nguyen, Quynh G, Beld, Joris, La Clair, James J, Burkart, Michael D   +5 more
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Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases. [PDF]

PLoS ONE, 2014
Members of the LuxI protein family catalyze synthesis of acyl-homoserine lactone (acyl-HSL) quorum sensing signals from S-adenosyl-L-methionine and an acyl thioester.
Quin H Christensen, Ryan M Brecht, Dastagiri Dudekula, E Peter Greenberg, Rajesh Nagarajan   +4 more
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Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency

eLife, 2023
Malonyl-CoA-acyl carrier protein transacylase (MCAT) is an enzyme involved in mitochondrial fatty acid synthesis (mtFAS) and catalyzes the transfer of the malonyl moiety of malonyl-CoA to the mitochondrial acyl carrier protein (ACP).
Bryn D Webb, Sara M Nowinski, Ashley Solmonson, Jaya Ganesh, Richard J Rodenburg, Joao Leandro, Anthony Evans, Hieu S Vu, Thomas P Naidich, Bruce D Gelb, Ralph J DeBerardinis, Jared Rutter, Sander M Houten   +12 more
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Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins

Biomolecules, 2022
The transfer of acyl chains to proteins and lipids from acyl-CoA donor molecules is achieved by the actions of diverse enzymes and proteins, including the acyl-CoA binding domain-containing protein ACBD6.
Eric Soupene, Frans A. Kuypers
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