Results 31 to 40 of about 89,834 (290)

High temperature during soybean seed development differentially alters lipid and protein metabolism

Plant Production Science, 2020
High temperatures during seed development can affect the seed yield and quality in many crops. Here, we analyzed how high temperature alters the main seed storage compounds (lipid and protein) in soybean. At five days after R5 stage (initial seed filling
Andressa C. S. Nakagawa, Nobuyuki Ario, Yuki Tomita, Seiya Tanaka, Naoki Murayama, Chiaki Mizuta, Mari Iwaya-Inoue, Yushi Ishibashi   +7 more
doaj   +1 more source

Enhanced Rishirilide Biosynthesis by a Rare In-Cluster Phosphopantetheinyl Transferase in Streptomyces xanthophaeus

Microbiology Spectrum, 2022
Phosphopantetheinyl transferases (PPTases) play important roles in activating apo-acyl carrier proteins (apo-ACPs) and apo-peptidyl carrier proteins (apo-PCPs) in both primary and secondary metabolism. PPTases catalyze the posttranslational modifications
Songya Zhang, Shuai Fan, Jing Zhu, Liying Zhou, Xiaohui Yan, Zhaoyong Yang, Tong Si, Tao Liu   +7 more
doaj   +1 more source

Versatility of Acyl-Acyl Carrier Protein Synthetases

Chemistry & Biology, 2014
The acyl carrier protein (ACP) requires posttranslational modification with a 4'-phosphopantetheine arm for activity, and this thiol-terminated modification carries cargo between enzymes in ACP-dependent metabolic pathways. We show that acyl-ACP synthetases (AasSs) from different organisms are able to load even, odd, and unnatural fatty acids onto E ...
Beld, Joris, Finzel, Kara, Burkart, Michael D.   +2 more
openaire   +2 more sources

Improving hydrocarbon production by engineering cyanobacterial acyl-(acyl carrier protein) reductase

Biotechnology for Biofuels, 2019
Background Acyl-(acyl carrier protein (ACP)) reductase (AAR) is a key enzyme for hydrocarbon biosynthesis in cyanobacteria, reducing fatty acyl-ACPs to aldehydes, which are then converted into hydrocarbons by aldehyde-deformylating oxygenase (ADO ...
Hisashi Kudo, Yuuki Hayashi, Munehito Arai   +2 more
doaj   +1 more source

ACBP and cholesterol differentially alter fatty acyl CoA utilization by microsomal ACAT

Journal of Lipid Research, 2003
Microsomal acyl CoA:cholesterol acyltransferase (AC57) is stimulated in vitro and/or in intact cells by proteins that bind and transfer both substrates, cholesterol, and fatty acyl CoA.
Hsu Chao, Minglong Zhou, Avery McIntosh, Friedhelm Schroeder, Ann B. Kier   +4 more
doaj   +1 more source

Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636 [PDF]

, 2008
The identification of potential new anti-tubercular cemotherapeutics is paramount due to the recent emergence of extensively drug-resistant strains of Mycobacterium tuberculosis (XDR-TB).Libraries of NAS-21 and NAS-91 analogues were synthesized and ...
Besra, Gurdyal S, Bhowruth, Veemal, Brown, Alistair K.   +2 more
core   +2 more sources

Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase

Nature Communications, 2020
Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production.
Yu Gao, Hongmei Zhang, Minrui Fan, Chenjun Jia, Lifang Shi, Xiaowei Pan, Peng Cao, Xuelin Zhao, Wenrui Chang, Mei Li   +9 more
doaj   +1 more source

Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli. [PDF]

PLoS ONE, 2018
BACKGROUND:Fatty acid synthase 1 (FAS I) from Mycobacterium tuberculosis (Mtb) is an essential protein and a promising drug target. FAS I is a multi-functional, multi-domain protein that is organized as a large (1.9 MDa) homohexameric complex.
Szilvia Baron, Yoav Peleg, Jacob Grunwald, David Morgenstern, Nadav Elad, Moshe Peretz, Shira Albeck, Yishai Levin, John T Welch, Kim A DeWeerd, Alon Schwarz, Yigal Burstein, Ron Diskin, Zippora Shakked, Oren Zimhony   +14 more
doaj   +1 more source

Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity

Antibiotics, 2022
Type II fatty acid synthases are promising drug targets against major bacterial pathogens. Platensimycin (PTM) is a potent inhibitor against β-ketoacyl-[acyl carrier protein] synthase II (FabF) and β-ketoacyl-[acyl carrier protein] synthase I (FabB ...
Youchao Deng, Yuling Li, Zhongqing Wen, Claudia H. Ruiz, Xiang Weng, Michael D. Cameron, Yanwen Duan, Yong Huang   +7 more
doaj   +1 more source

Structural classification of biotin carboxyl carrier proteins [PDF]

, 2012
We gathered primary and tertiary structures of acyl-CoA carboxylases from public databases, and established that members of their biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains occur in one family each and that members of ...
Cantu, David, Chen, Yingfei, Elizondo-Noriega, Armando, Reilly, Peter, Reilly, Peter   +4 more
core   +3 more sources