Results 21 to 30 of about 47,643 (280)

A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis

Frontiers in Microbiology, 2022
The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li, Qian Huang, Weidi Zhang, Yinghua Cao, Zhanxin Wang, Zhenwen Zhao, Xiaotian Zhang, Junjie Zhang   +7 more
doaj   +1 more source

Acylation of the Type 3 Secretion System Translocon Using a Dedicated Acyl Carrier Protein. [PDF]

PLoS Genetics, 2017
Bacterial pathogens often deliver effectors into host cells using type 3 secretion systems (T3SS), the extremity of which forms a translocon that perforates the host plasma membrane.
Julie P Viala, Valérie Prima, Rémy Puppo, Rym Agrebi, Mickaël J Canestrari, Sabrina Lignon, Nicolas Chauvin, Stéphane Méresse, Tâm Mignot, Régine Lebrun, Emmanuelle Bouveret   +10 more
doaj   +1 more source

Involvement of Arabidopsis Acyl Carrier Protein 1 in PAMP-Triggered Immunity

Molecular Plant-Microbe Interactions, 2022
Plant fatty acids (FAs) and lipids are essential in storing energy and act as structural components for cell membranes and signaling molecules for plant growth and stress responses.
Zhenzhen Zhao, Jiangbo Fan, Piao Yang, Zonghua Wang, Stephen Obol Opiyo, David Mackey, Ye Xia   +6 more
doaj   +1 more source

Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics [version 2; peer review: 2 approved]

F1000Research, 2022
Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics.
Vladyslav Yadrykhins'ky, Ruth Brenk, Charis Georgiou   +2 more
doaj   +1 more source

Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases. [PDF]

PLoS ONE, 2014
Members of the LuxI protein family catalyze synthesis of acyl-homoserine lactone (acyl-HSL) quorum sensing signals from S-adenosyl-L-methionine and an acyl thioester.
Quin H Christensen, Ryan M Brecht, Dastagiri Dudekula, E Peter Greenberg, Rajesh Nagarajan   +4 more
doaj   +1 more source

2-Acylglycerolphosphoethanolamine acyltransferase/acyl-acyl carrier protein synthetase is a membrane-associated acyl carrier protein binding protein

Journal of Biological Chemistry, 1989
Two enzymatic activities, 2-acylglycerolphosphoethanolamine (2-acyl-GPE) acyltransferase and acyl-acyl carrier protein (acyl-ACP) synthetase, were solubilized and purified from Escherichia coli membranes. Electrophoretic analysis of the final product of the purification procedure revealed a single protein species with an apparent molecular mass of 27 ...
Cynthia L. Cooper, Li-Chieh Hsu, Suzanne Jackowski, Charles O. Rock   +3 more
openalex   +3 more sources

Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency

eLife, 2023
Malonyl-CoA-acyl carrier protein transacylase (MCAT) is an enzyme involved in mitochondrial fatty acid synthesis (mtFAS) and catalyzes the transfer of the malonyl moiety of malonyl-CoA to the mitochondrial acyl carrier protein (ACP).
Bryn D Webb, Sara M Nowinski, Ashley Solmonson, Jaya Ganesh, Richard J Rodenburg, Joao Leandro, Anthony Evans, Hieu S Vu, Thomas P Naidich, Bruce D Gelb, Ralph J DeBerardinis, Jared Rutter, Sander M Houten   +12 more
doaj   +1 more source

Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier protein reductase (InhA). [PDF]

RSC Adv
Batran RZ, Sabt A, Dziadek J, Kassem AF.
europepmc   +3 more sources

Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins

Biomolecules, 2022
The transfer of acyl chains to proteins and lipids from acyl-CoA donor molecules is achieved by the actions of diverse enzymes and proteins, including the acyl-CoA binding domain-containing protein ACBD6.
Eric Soupene, Frans A. Kuypers
doaj   +1 more source

The Enterococcus faecalis FabT Transcription Factor Regulates Fatty Acid Biosynthesis in Response to Exogeneous Fatty Acids

Frontiers in Microbiology, 2022
The phospholipid acyl chains of Enterococcus faecalis can be derived either by de novo synthesis or by incorporation of exogenous fatty acids through the fatty acid kinase complex (Fak)-phosphate acyltransferase (PlsX) pathway.
Qi Zou, Huijuan Dong, Lei Zhu, John E. Cronan, John E. Cronan   +4 more
doaj   +1 more source