Results 21 to 30 of about 74,334 (181)
CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases [PDF]
EMBO Molecular Medicine, 2019 PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA ...
Roald A Lambrechts +10 more
doaj +2 more sources
Concurrent growth rate and transcript analyses reveal essential gene stringency in Escherichia coli [PDF]
, 2009 BACKGROUND: Genes essential for bacterial growth are of particular scientific interest. Many putative essential genes have been identified or predicted in several species, however, little is known about gene expression requirement stringency, which may ...
Boberek, Jaroslaw M +4 more
core +21 more sources
Interfacial Enzymes Enable Gram-Positive Microbes to Eat Fatty Acids
Membranes, 2023 Exogenous fatty acid (eFA) activation and utilization play key roles in bacterial physiology and confer growth advantages by bypassing the need to make fatty acids for lipid synthesis.
Christopher D. Radka
doaj +1 more source
Frontiers in Microbiology, 2022 The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li +7 more
doaj +1 more source
Involvement of Arabidopsis Acyl Carrier Protein 1 in PAMP-Triggered Immunity
Molecular Plant-Microbe Interactions, 2022 Plant fatty acids (FAs) and lipids are essential in storing energy and act as structural components for cell membranes and signaling molecules for plant growth and stress responses.
Zhenzhen Zhao +6 more
doaj +1 more source
Acylation of the Type 3 Secretion System Translocon Using a Dedicated Acyl Carrier Protein. [PDF]
PLoS Genetics, 2017 Bacterial pathogens often deliver effectors into host cells using type 3 secretion systems (T3SS), the extremity of which forms a translocon that perforates the host plasma membrane.
Julie P Viala +10 more
doaj +1 more source
Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases. [PDF]
PLoS ONE, 2014 Members of the LuxI protein family catalyze synthesis of acyl-homoserine lactone (acyl-HSL) quorum sensing signals from S-adenosyl-L-methionine and an acyl thioester.
Quin H Christensen +4 more
doaj +1 more source
Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency
eLife, 2023 Malonyl-CoA-acyl carrier protein transacylase (MCAT) is an enzyme involved in mitochondrial fatty acid synthesis (mtFAS) and catalyzes the transfer of the malonyl moiety of malonyl-CoA to the mitochondrial acyl carrier protein (ACP).
Bryn D Webb +12 more
doaj +1 more source
Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins
Biomolecules, 2022 The transfer of acyl chains to proteins and lipids from acyl-CoA donor molecules is achieved by the actions of diverse enzymes and proteins, including the acyl-CoA binding domain-containing protein ACBD6.
Eric Soupene, Frans A. Kuypers
doaj +1 more source
Frontiers in Microbiology, 2022 The phospholipid acyl chains of Enterococcus faecalis can be derived either by de novo synthesis or by incorporation of exogenous fatty acids through the fatty acid kinase complex (Fak)-phosphate acyltransferase (PlsX) pathway.
Qi Zou +4 more
doaj +1 more source