Results 91 to 100 of about 10,947 (199)

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Serum acylcarnitines profile at ICU discharge to predict mid-term muscle outcomes: an exploratory study

Frontiers in Medicine
BackgroundAlterations in acylcarnitines (AC) profile may reflect mitochondrial and metabolic disturbances after critical illness. This study investigated the association between AC profile at ICU discharge (ICUD) and muscle outcomes assessed 3 months (M3)
Anne-Françoise Rousseau, Anne-Françoise Rousseau, Frédéric Farnir, Etienne Cavalier, Géraldine Luis, Isabelle Kellens, Bernard Lambermont, François Boemer   +7 more
doaj   +1 more source

The significance of acylcarnitine ratio indices in diagnosing carnitine-acylcarnitine translocase deficiency

Translational Pediatrics, 2023
Shi, Congcong, Hao, Hu, Li, Sitao
openaire   +2 more sources

The Dietary Protein Source Modulates Obesity Development and Induces Distinct Plasma Lipid Profiles and Transcriptome Profiles in Liver and Adipose Tissue

Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.
By performing plasma metabolomics analyses combined with RNA sequencing and gene set enrichment analyses of liver, muscle, white‐ and brown‐adipose tissue in mice, we aimed to decipher the metabolic output and pathways modulated by intake of different dietary proteins.
Lene S. Myrmel, Even Fjære, Annette Bernhard, Josef D. Rasinger, Ole Jakob Nøstbakken, Helene Søiland, Philipp Rausch, Martin von Bergen, Ulrike Rolle‐Kampzcyk, Liang Xiao, Hanlin Zhou, Guibo Li, Karsten Kristiansen, Lise Madsen   +13 more
wiley   +1 more source

Acylcarnitine ratio indices in diagnosing carnitine-acylcarnitine translocase deficiency in newborns

Translational Pediatrics, 2023
Tan, Yifei, Wang, Ling, Qi, Xiaoying, Feng, Qingbo, Luo, Hong   +4 more
openaire   +2 more sources

Muscle Mitochondrial Oxidative Capacity and Cognitive Decline Over up to a Decade: Sex Differences

Aging Cell, Volume 25, Issue 8, August 2026.
Skeletal muscle mitochondrial oxidative capacity is linked to cognition and predicts cognitive decline primarily in men. Underlying mechanisms appear to differ by sex, likely through a metabolic‐drive pathway in men and a hematologic‐inflammatory pathway in women.
Qu Tian, Anjay Ambegaonkar, Luigi Ferrucci   +2 more
wiley   +1 more source

Intra-individual variability of the human seminal plasma metabolome

Asian Journal of Andrology
In contrast to the conventional spermiogram, metabolomics approaches give insights into the molecular composition of semen and may provide more detailed information on the fertility status of the respective donor.
Janet Blaurock, Sonja Grunewald, Kathrin M Engel   +2 more
doaj   +1 more source

Apiotrichum‐Centered Fungal Interaction Network Disturbance Correlates With Increased Arterial Stiffness

Aging Cell, Volume 25, Issue 8, August 2026.
Apiotrichum‐centered gut fungal network disturbance correlates with increased arterial stiffness. Five driver genera including Apiotrichum, Mycothermus, Flavocillium, Hyaloscypha, and Microscypha regulate the interaction shift. Thirty‐nine metabolites comprising organic acids, fatty acyls, and sucrose target vasoconstriction regulators CYP11B2, ROCK2 ...
Jiarui Chen, Jialin He, Bingqi Ye, Jialu Yang, Ludi Liu, Jingmeng Ju, Sinan Li, Benjie Li, Min Xia, Yan Liu   +9 more
wiley   +1 more source

Gene networks and metabolomic screening analysis revealed specific pathways of amino acid and acylcarnitine profile alterations in blood plasma of patients with Parkinson’s disease and vascular parkinsonism

Вавиловский журнал генетики и селекции
Parkinson’s disease (PD) and vascular parkinsonism (VP) are characterized by similar neurological syndromes but differ in pathogenesis, morphology, and therapeutic approaches.
A. A. Makarova, P. M. Melnikova, A. D. Rogachev, P. S. Demenkov, T. V. Ivanisenko, E. V. Predtechenskaya, S. Y. Karmanov, V. V. Koval, A. G. Pokrovsky, I. N. Lavrik, N. A. Kolchanov, V. A. Ivanisenko   +11 more
doaj   +1 more source

High heritability of metabolomic profiles in families burdened with premature cardiovascular disease

Molecular Systems Biology, 2009
Integration of genetic and metabolic profiling holds promise for providing insight into human disease. Coronary artery disease (CAD) is strongly heritable, but the heritability of metabolomic profiles has not been evaluated in humans.
Svati H Shah, Elizabeth R Hauser, James R Bain, Michael J Muehlbauer, Carol Haynes, Robert D Stevens, Brett R Wenner, Z Elaine Dowdy, Christopher B Granger, Geoffrey S Ginsburg, Christopher B Newgard, William E Kraus   +11 more
doaj   +1 more source