Results 171 to 180 of about 2,678 (221)

Isomerization of bioactive acylhydrazones triggered by light or thiols

Nature Chemistry, 2023
The acylhydrazone unit is well represented in screening databases used to find ligands for biological targets, and numerous bioactive acylhydrazones have been reported. However, potential E/Z isomerization of the C=N bond in these compounds is rarely examined when bioactivity is assayed. Here we analysed two ortho-hydroxylated acylhydrazones discovered
Zhiwei Zhang, Giang N. T. Le, Yang Ge, Xiaowen Tang, Xin Chen, Linda Ejim, Emily Bordeleau, Gerard D. Wright, Darcy C. Burns, Susannah Tran, Peter Axerio-Cilies, Yu Tian Wang, Mingxin Dong, G. Andrew Woolley   +13 more
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N-Acylhydrazones as inhibitors of PDE10A

Bioorganic & Medicinal Chemistry Letters, 2011
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were efficacious in animal models of schizophrenia and may be useful for the treatment of this disease.
Jennifer L, Gage, Rene, Onrust, Derek, Johnston, Andrew, Osnowski, Wendy, Macdonald, Lee, Mitchell, László, Urögdi, Alex, Rohde, Kevin, Harbol, Sasha, Gragerov, György, Dormán, Tom, Wheeler, Vince, Florio, Neil S, Cutshall   +13 more
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Discovery of novel acylhydrazone neuraminidase inhibitors

European Journal of Medicinal Chemistry, 2019
Neuraminidase (NA) plays a crucial role in the replication and transmission of influenza virus. NA inhibitors have been developed as effective treatments for influenza A and B infections. In this paper, a new lead neuraminidase inhibitor 6a (IC50 = 7.10 ± 0.2 μM) was discovered by ligand-based virtual screening, receptor-based virtual screening ...
Zhi Xiang Zhao, Li Ping Cheng, Meng Li, Wan Pang, Fan Hong Wu   +4 more
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Strecker Reactions of Chiral N‐Acylhydrazones.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gregory K. Friestad, Hui Ding
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D-arabino-hexosulose bis(acylhydrazones) and 2-acylhydrazone 1-arylhydrazones

Carbohydrate Research, 1967
Abstract D - arabino -Hexosulose bis(acylhydrazones) ( 1–4 ), 2-acylhydrazone 1-phenylhydrazones ( 5–16 ), and 2-acylhydrazone 1-(2-methyl-2-phenyl)hydrazones ( 17–24 ) were prepared from D - arabino -hexosulose or its hydrazone and acylhydrazines. The properties of these osazones were compared with those of arylosazones and bis(benzoylhydrazones).
H. El Khadem, M.A.E. Shaban
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Some ferrocene derivatives of acylhydrazones

Wuhan University Journal of Natural Sciences, 1998
The title organometallic compounds were synthesized by the condensation of formyl and acetyl ferrocene with cyanoacetyl, propionyl, butyryl,o-furoyl,o-thiofuroyl andm-pyridinecarboxy hydrazine in anhydrous ethanol under reflux. The IR,1H NMR, MS, and Mossbauer spectra for these compounds were recorded and are discussed.
Ding Zirong, Peng Chen, Zhang Lun, Zhao Qingbo, Chen Sunian, Qi Shoure   +5 more
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Catalytic hydrophosphorylation of alkyl- and acylhydrazones

Russian Chemical Bulletin, 2010
N-Boc- and N-acylhydrazino phosphonates were obtained for the first time by hydrophosphorylation of the appropriate hydrazones of aliphatic and aromatic aldehydes and heterocyclic and aliphatic ketones in the presence of [tetra(tert-butyl)phthalocyanine]aluminum chloride as a catalyst.
E. D. Matveeva, T. A. Podrugina, I. N. Kolesnikova, M. V. Prisyazhnoi, G. G. Karateev, N. S. Zefirov   +5 more
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Deciphering the grounds of the suitability of acylhydrazones as efficient photoswitches

Physical Chemistry Chemical Physics, 2019
Calculations on several acylhydrazones are carried out to explain their diverse photochemistry experimentally observed. Results disclose the role of the intramolecular proton transfer or the loss of the azidic proton in the large Stokes shift.
Miquel Moreno, Ricard Gelabert, José M. Lluch   +2 more
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Phenyliodonium diacetate mediated carbotrifluoromethylation of N-acylhydrazones

Organic & Biomolecular Chemistry, 2016
A concise, efficient and direct trifluoromethylation method of aldehyde-derivedN-acylhydrazones has been firstly developed by using the combination of inexpensive, stable and commercially available TMSCF3and PhI(OAc)2as the CF3source under mild reaction conditions.
Weigang Zhang, Yingpeng Su, Siying Chong, Lili Wu, Guiyan Cao, Danfeng Huang, Ke-Hu Wang, Yulai Hu   +7 more
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Synthesis and application of hypochlorite mediated acylhydrazone fluorescence probes

Luminescence, 2023
AbstractHypochlorous acid (HClO/ClO−) is one of the important reactive oxygen species (ROS). It acts as a second signaling molecule within and between cells and is an indispensable active molecule in living organisms to regulate physiological and pathological processes.
Chenglu Zhang, Xiangling Li, Yiming Wang, Shiru Nie, Chang Liu   +4 more
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