Results 91 to 100 of about 86,883 (336)

Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2−/− lipodystrophic mice independent of hepatocyte leptin receptors[S]

Journal of Lipid Research, 2014
Leptin is essential for energy homeostasis and regulation of food intake. Patients with congenital generalized lipodystrophy (CGL) due to mutations in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) and the CGL murine model (Agpat2−/− mice) both ...
Víctor A. Cortés, Kelly M. Cautivo, Shunxing Rong, Abhimanyu Garg, Jay D. Horton, Anil K. Agarwal   +5 more
doaj   +1 more source

Molecular species of phosphatidylcholine in abetalipoproteinemia: effect of lecithin:cholesterol acyltransferase and lysolecithin acyltransferase.

Journal of Lipid Research, 1989
In order to study the role of very low density lipoproteins (VLDL) and low density lipoproteins (LDL) in determining the molecular species composition of phosphatidylcholine (PC) and the specificity of lecithin:cholesterol acyltransferase (LCAT) in human plasma, we studied the PC species composition in plasma from abetalipoproteinemic (ABL) and control
R. E. Gregg, Papasani V. Subbaiah, John D. Bagdade, B. Banerji   +3 more
openaire   +4 more sources

Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47

Cancer Communications, EarlyView.
Abstract Background Only a few bladder cancer patients benefit from anti‐programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immune evasion. CD47 is a highly glycosylated protein, however, the mechanisms governing CD47 glycosylation and its potential ...
Jie Zhang, Chen Zhang, Ruichen Zang, Weiwu Chen, Yining Guo, Haofei Jiang, Jing Le, Kunyu Wang, Haobo Fan, Xudong Wang, Sisi Mo, Peng Gao, Wenhao Guo, Xinrong Jiang, Fengbin Gao, Junming Jiang, Juyan Zheng, Yuxing Chen, Yicheng Chen, Yanlan Yu, Guoqing Ding   +20 more
wiley   +1 more source

GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis[S]

Journal of Lipid Research, 2010
Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report the further characterization of the two recently identified microsomal GPAT3
Dandan Shan, Jian-liang Li, Leeying Wu, Dongmei Li, Jonathan Hurov, James F. Tobin, Ruth E. Gimeno, Jingsong Cao   +7 more
doaj   +1 more source

Attribution of ghrelin to cancer; Attempts to unravel an apparent controversy [PDF]

, 2019
Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute
Khani, Leila, Pastaki Khoshbin, Amin, Roosta, Venus, Sadeghi, Fatemeh, Soleyman-Jahi, Saeed, Zendehdel, Kazem   +5 more
core   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]

, 2009
OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali, Bacha, Nafees, Lebrihi, Ahmed, Liboz, Thierry, Mathieu, Florence   +4 more
core   +1 more source

Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane

ChemBioChem, EarlyView.
SLIPT‐PM enables the translocation of tag‐fused proteins from the cytoplasm to the plasma membrane using a synthetic self‐localizing ligand. This user‐friendly system permits reversible control of diverse signaling pathways. This concept article highlights the key features and current applications of SLIPT‐PM as a powerful tool in chemical and ...
Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji   +3 more
wiley   +1 more source