Results 201 to 210 of about 58,776 (313)

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

Redundant Glycerol-3-Phosphate Acyltransferases Regulate Thermo-Sensitive Genic Male Sterility in Rice. [PDF]

Plant Biotechnol J
Cheng S, Zheng H, Tian Y, Wang C, Yu X, Dong K, Wang J, Lu J, Chen K, He X, Shao K, Gao J, Yao B, Hu Y, Xie Z, He L, Xie Z, Zhu Y, Guo S, Lei D, Jian A, Zhu X, Yu H, Zhang S, Chen M, Chen Y, Jiang L, Ren Y, Guo X, Liu S, Liu X, Zhu S, Zhao Z, Wan J.   +33 more
europepmc   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

Oil as a Hindrance to Oat (<i>Avena sativa</i> L.) Nutrient Fractionation: Leveraging Mass Spectrometry-Based Omics to Unravel Lipid Regulation for Functional Crop Improvement. [PDF]

Foods
Lau D, Donnellan L, Harris JC, Hoffmann P.   +3 more
europepmc   +1 more source

Insights Into Gut Microbiota and Metabolic Alterations in Type 1 Diabetes Mellitus

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
Caroline Fogagnolo, Gabriela Ueta Ortiz, Adelino Sanchez Ramos da Silva, Ellen Cristini de Freitas   +3 more
wiley   +1 more source

Reprogramming Glial Cell Metabolism via a tRNA Fragment Preserves Vision in Retinal Neurodegeneration

MedComm, Volume 7, Issue 8, August 2026.
Under oxidative and excitotoxic stress, Müller cell‐derived 5′tiRNA‐His‐GTG contributes to retinal neurodegeneration. Pathological stimuli increase ANG‐dependent production of 5′tiRNA‐His‐GTG, which suppresses LPCAT1 expression and disrupts phosphatidylcholine (PC)‐mediated glycerophospholipid metabolism.
Yuke Ji, Sha Liu, Ying Zhang, Junya Zhu, Chang Huang, Ya Zhao, Jiao Xia, Wan Mu, Jin Yao, Biao Yan   +9 more
wiley   +1 more source

Heterologous Production of Barnesin A, an NRPS-PKS Hybrid Containing a Rare Vinylogous Arginine Moiety. [PDF]

Chembiochem
Balluff S, Dayras M, Beemelmanns C.
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Lecithin-Retinol Acyltransferase-Cre Exhibits Widespread Expression Beyond Hepatic Stellate Cells Across Multiple Tissues. [PDF]

Gastro Hep Adv
Kim K, Taleb S, So J, Wann J, Roh HC.
europepmc   +1 more source