Results 221 to 230 of about 58,776 (313)

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, Volume 13, Issue 42, 28 July 2026.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Biocatalytic Regioselective C-Formylation of Resorcinol Derivatives. [PDF]

Angew Chem Int Ed Engl
Gal L, Rohan S, Żądło-Dobrowolska A, Hilweg B, Müller J, Tittmann K, Kroutil W.   +6 more
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, Volume 13, Issue 41, 22 July 2026.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

BnaC03.SEIPIN1 improves seed oil content by increasing the number of lipid droplets in Brassica napus. [PDF]

BMC Plant Biol
Li Y, Cao Z, Xiang Y, Guo L, Zu F, Wang T, Li M, Li B, Lu S.   +8 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, Volume 13, Issue 41, 22 July 2026.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Fatty acid esters of hydroxy fatty acids and alkyl-diacylglycerols: minor but bioactive components in human milk. [PDF]

Biochem Soc Trans
Lee MLX, Elejalde U, Cazenave-Gassiot A.
europepmc   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao, Wei Liu, Xiuping Liang, Jie Bai, Hong Chang, Wenchao Chen, Mohamed A. Farag, Jianbo Xiao, Huifeng Jiang, Jiasheng Wu, Lili Song   +10 more
wiley   +1 more source

Organelle regulation of ferroptosis after intracerebral hemorrhage. [PDF]

Redox Biol
Zhou N, Du Y, Wang Y, Zhao X, Ju Y.
europepmc   +1 more source

Lipid Droplet–Mitochondria Interactions: From Molecular Components to Spatial Aggregation Manipulation

Aggregate, Volume 7, Issue 7, July 2026.
This review summarizes recent advances in lipid droplet–mitochondria interactions that regulate lipid homeostasis, covering contact‐site classification, protein complexes, dual roles in catabolism and storage, and associated diseases, while optogenetic manipulation of organelle spatial aggregation is emerging as a powerful tool for precise subcellular ...
Qingjie Bai, Yanan Gao, Shulin Zhao, Xunxun Wu, Kun Zhao, Xintian Shao, Qinghua Xia, Jianning Wang, Qixin Chen, Xiaofei Chen   +9 more
wiley   +1 more source