Results 51 to 60 of about 101,485 (290)

Automated structure prediction of trans-acyltransferase polyketide synthase products

Nature Chemical Biology, 2019
Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) are among the most complex known enzymes from secondary metabolism and are responsible for the biosynthesis of highly diverse bioactive polyketides.
Eric J. N. Helfrich, Reiko Ueoka, A. Dolev, M. Rust, Roy A. Meoded, Agneya Bhushan, Gianmaria Califano, R. Costa, M. Gugger, C. Steinbeck, P. Moreno, J. Piel   +11 more
semanticscholar   +1 more source

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
core   +3 more sources

Type II Secretion-Dependent Aminopeptidase LapA and Acyltransferase PlaC Are Redundant for Nutrient Acquisition during Legionella pneumophila Intracellular Infection of Amoebas

mBio, 2018
Legionella pneumophila genes encoding LapA, LapB, and PlaC were identified as the most highly upregulated type II secretion (T2S) genes during infection of Acanthamoeba castellanii, although these genes had been considered dispensable on the basis of the
Richard C. White, Felizza F. Gunderson, Jessica Y. Tyson, Katherine H. Richardson, Theo J. Portlock, James A. Garnett, Nicholas P. Cianciotto   +6 more
doaj   +1 more source

Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis

Science Translational Medicine, 2019
Inhibition of DGAT2 reduces steatosis, inflammation, and fibrosis in rodent models of NASH and reduces liver fat in clinical testing. A pill a day keeps liver fat away Nonalcoholic fatty liver diseases can progress to liver failure but currently lack ...
N. Amin, S. Carvajal-Gonzalez, Julie J. Purkal, Tong Zhu, Collin Crowley, Sylvie Perez, Kristin Chidsey, Albert M. Kim, B. Goodwin   +8 more
semanticscholar   +1 more source

Membrane Topology of Hedgehog Acyltransferase [PDF]

Journal of Biological Chemistry, 2015
Hedgehog acyltransferase (Hhat) is a multipass transmembrane enzyme that mediates the covalent attachment of the 16-carbon fatty acid palmitate to the N-terminal cysteine of Sonic Hedgehog (Shh). Palmitoylation of Shh by Hhat is critical for short and long range signaling.
Armine Matevossian, Marilyn D. Resh
openaire   +2 more sources

The pleiotropic transcriptional regulator NlpR contributes to the modulation of nitrogen metabolism, lipogenesis and triacylglycerol accumulation in oleaginous rhodococci [PDF]

, 2017
The regulatory mechanisms involved in lipogenesis and triacylglycerol (TAG) accumulation are largely unknown in oleaginous rhodococci. In this study a regulatory protein (here called NlpR: Nitrogen lipid Regulator), which contributes to the modulation of
Alvarez, Hector Manuel, Gago, Gabriela Marisa, Gramajo, Hugo Cesar, Hernández, Martín Alejandro, Lara, María Julia   +4 more
core   +1 more source

Characterization of Genes Involved in the Formation of Aroma Volatiles in "Charentais" Melon Fruit [PDF]

, 2004
Volatiles esters impart distinct characteristics to the fruit quality. "Charentais" cantaloupe melon (Cucumis melo "cantalupensis") is characterized by abundant sweetness and aromatic flavour.
El-Sharkawy, Islam, Flores, Francisco B., Latché, Alain, Manriquez, Daniel, Pech, Jean-Claude   +4 more
core   +1 more source

Short-chain fatty acids activate acetyltransferase p300

eLife, 2021
Short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced in large quantities by the gut microbiome and contribute to a wide array of physiological processes. While the underlying mechanisms are largely unknown, many effects of SCFAs
Sydney P Thomas, John M Denu
doaj   +1 more source

Properties and Biotechnological Applications of Acyl-CoA:diacylglycerol Acyltransferase and Phospholipid:diacylglycerol Acyltransferase from Terrestrial Plants and Microalgae.

Lipids, 2018
Triacylglycerol (TAG) is the major storage lipid in most terrestrial plants and microalgae, and has great nutritional and industrial value. Since the demand for vegetable oil is consistently increasing, numerous studies have been focused on improving the
Yang Xu, K. M. Caldo, Dipasmita Pal-Nath, J. Ozga, M. Joanne Lemieux, R. Weselake, Guanqun Chen   +6 more
semanticscholar   +1 more source

Genome-Wide Analysis of Serine Carboxypeptidase-Like Acyltransferase Gene Family for Evolution and Characterization of Enzymes Involved in the Biosynthesis of Galloylated Catechins in the Tea Plant (Camellia sinensis)

Frontiers in Plant Science, 2020
Tea (Camellia sinensis L.) leaves synthesize and concentrate a vast array of galloylated catechins (e.g., EGCG and ECG) and non-galloylated catechins (e.g., EGC, catechin, and epicatechin), together constituting 8%–24% of the dry leaf mass.
Muhammad Zulfiqar Ahmad, Penghui Li, Guangbiao She, Enhua Xia, Vagner A. Benedito, Xiao Chun Wan, Jian Zhao   +6 more
doaj   +1 more source