Results 121 to 130 of about 75,759 (281)

Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding

Nature Communications
Overexpression of the transmembrane matrix metalloproteinase MT1-MMP/MMP14 promotes cancer cell invasion. Here we show that MT1-MMP-positive cancer cells turn MT1-MMP-negative cells invasive by transferring a soluble catalytic ectodomain of MT1-MMP ...
Eva Maria Wenzel, Nina Marie Pedersen, Liv Anker Elfmark, Ling Wang, Ingrid Kjos, Espen Stang, Lene Malerød, Andreas Brech, Harald Stenmark, Camilla Raiborg   +9 more
doaj   +1 more source

Inactive metallopeptidase homologs: the secret lives of pseudopeptidases

Frontiers in Molecular Biosciences
Inactive enzyme homologs, or pseudoenzymes, are proteins, found within most enzyme families, that are incapable of performing catalysis. Rather than catalysis, they are involved in protein-protein interactions, sometimes regulating the activity of their ...
Peter J. Lyons
doaj   +1 more source

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

Clinical Pharmacology &Therapeutics, EarlyView.
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Nihan Izat, Haribhau Kangne, Rasmus Jansson‐Löfmark, Jens K. Hertel, Amin Rostami‐Hodjegan, Ida Robertsen, Aleksandra Galetin   +6 more
wiley   +1 more source

A disintegrin and metallopeptidase domain (ADAM) 12, ADAM 17 mRNA and ADAM10 protein hold potential as biomarkers for detection of early gastric cancer

Scientific Reports
AbstractNo biomarker can effectively screen for early gastric cancer (EGC). Players in the A disintegrin and metalloproteinase (ADAM)-natural killer group 2 member D (NKG2D) receptor axis may have a role for that. As a proof-of-concept pilot study, the expression of ADAM8, ADAM9, ADAM10, ADAM12, ADAM17, and major histocompatibility complex (MHC) class ...
Sooyeon Oh, Sang-Soo Lee, Hoeyoung Jin, Seo-Hyeon Choi, Choong-Keun Cha, Jooho Lee, KyuBum Kwack, Sang Gyun Kim, Sang-Woon Choi   +8 more
openaire   +3 more sources

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

ADAM 13: A Novel ADAM Expressed in Somitic Mesoderm and Neural Crest Cells duringXenopus laevisDevelopment

, 1997
Embryonic development involves a series of cell adhesive interactions that provide mechanical and instructive information required for morphogenesis. The ADAMs family of membrane-anchored proteins, containinga disintegrinandmetalloprotease domain, is ...
Wolfsberg, Tyra G., DeSimone, Douglas W., Alfandari, Dominique, White, Judith M.   +3 more
core   +1 more source

Determination of Aflatoxins and Selected Heavy Metals in Rice Varieties Cultivated in Fogera, Amhara Region, Ethiopia

Food Chemistry International, EarlyView.
ABSTRACT Rice (Oryza sativa L.) is a vital staple crop for nearly half the world's population. This study investigates the levels of aflatoxins (AFB1, AFB2, AFG1, and AFG2) and selected heavy metals (Cd, Pb, and Cr) and essential elements (Mn, Fe, Mg, Cu, and Zn) in rice varieties cultivated in Fogera, Amhara Region, Ethiopia.
Melese Tilahun, Bisratewongel Tegegne, Nibret Mekonen, Agegnehu Alemu   +3 more
wiley   +1 more source

Characterisation of ADAMs (protein)of bovine seminal plasma by Mass Spectrometry

Kufa Journal For Veterinary Medical Sciences, 2019
This study has been designed to analyse the secreted and soluble proteins in bovine seminal plasma by mass spectrometry. The majority of these proteins are produced by accessory glands, and partially by testis, epididymis, ductus deferens and vas deferens of male reproductive tract. Seminal plasma of bovine was collected freshly and isolated ...
openaire   +2 more sources

the phylogenetic history of ADAM proteins made from the mind-meld (mmd) gene in Drosophila

, 2020
My research contributes a better understanding of how the mmd gene has developed over evolutionary time to serve an integral role in neuronal membrane function, and how the Drosophila gene has arisen from ancestral genes in distant as well as closely ...
Ankrum, Alivia
core  

Combining phenotypic, physiological, and multi‐omics studies to provide new insights on the role of 2,4‐epibrassinolide in regulation of seed shattering in Elymus sibiricus L.

Grassland Research, EarlyView.
Abstract Background Seed shattering limits the production of Elymus sibiricus L., and application of exogenous brassinosteroid significantly alleviates plant organ abscission. Methods To explore the potential regulatory network of brassinosteroid on seed shattering, the abscission zone of E. sibiricus cv. Lanyu No.
Huanhuan Lu, Yiyang Wan, Liuban Tang, Yongsen Qiu, Yancui Zhao, Yuying Zheng, Wengang Xie   +6 more
wiley   +1 more source