Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review [PDF]
Current Issues in Molecular Biology, 2023 Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role
Agnieszka Kalita +2 more
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ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis [PDF]
BMB Reports, 2013 The ADAM and ADAMTS families, also called adamalysinsbelong to an important group of extracellular matrix proteins.The ADAMs family belong to both the transmembrane andsecreted proteins, while ADAMTS family only containssecreted forms.
Leszczynski Przemyslaw +3 more
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A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. [PDF]
PLoS ONE, 2011 Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Emanuela Leonardi +5 more
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ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview [PDF]
Toxins, 2016 A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors ...
Soichi Takeda
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Conservation and divergence of ADAM family proteins in the
BMC Evolutionary Biology, 2010 Background Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins.
Shah Anoop +6 more
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Correlation Between A Disintegrin and Metalloproteinase (ADAM) Family Proteins (8, 10, 17, 22) and Link with Neuroplasticity in Autism Spectrum Disorder [PDF]
Current Issues in Molecular BiologyBackground: Autism spectrum disorder (ASD) is a condition related to neurodevelopment, typically identified by impaired social interactions and repetitive stereotypical behaviors.
Dost Muhammad Halepoto +6 more
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ADAM-17/FHL2 colocalisation suggests interaction and role of these proteins in colorectal cancer [PDF]
Tumor Biology, 2017 FHL2 is a multifunctional scaffolding protein; its expression is associated with poor prognosis in colorectal cancer. ADAM-17 is a metalloprotease implicated in ectodomain shedding. FHL2 regulates ADAM-17 plasma membrane localisation, and FHL2 deficiency
Laurine Verset +7 more
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Mechanoresponsive ion channels Piezo1 and TRPV4 stimulate ADAM10 and ADAM17 with differential impact on endothelial migration and proliferation [PDF]
Cell Communication and SignalingBackground Endothelial cells are constantly exposed to mechanical forces generated by blood flow regulating endothelial homeostasis. Pathological events such as vascular injury or thrombus formation alter these forces, which are sensed by endothelial ...
Alessa Pabst +7 more
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European Journal of Cell Biology, 2011 ADAM metalloproteases are membrane bound glycoproteins that control many biological processes during development and differentiation, mainly by acting as ectodomain sheddases. The Drosophila genome contains five genes that code for classical ADAM proteins which are characterized by a highly conserved domain structure with the respective catalytic ...
Heiko Meyer +2 more
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Adam13 interacts with large protein complexes to regulate histone modification and gene expression [PDF]
Frontiers in Cell and Developmental BiologyCranial neural crest (CNC) cells are a key stem cell like tissue that contribute to most of the facial structures in vertebrates. A disintegrin and metalloproteinase (ADAM) family of proteins is essential for the induction and migration of the CNC.
Ankit Pandey +10 more
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