Results 31 to 40 of about 67,878 (248)

A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site

Toxins, 2023
A disintegrin and metalloproteinase (ADAM) family proteins are a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell surface protein ectodomains, including amyloid precursor protein (APP).
Eugene Futai, Hajime Kawasaki, Shinichi Sato, Khadija Daoudi, Masafumi Hidaka, Taisuke Tomita, Tomohisa Ogawa   +6 more
doaj   +1 more source

Characterization of Mammalian ADAM2 and Its Absence from Human Sperm. [PDF]

PLoS ONE, 2016
The members of the ADAM (a disintegrin and metalloprotease) family are membrane-anchored multi-domain proteins that play prominent roles in male reproduction.
Heejin Choi, Sora Jin, Jun Tae Kwon, Jihye Kim, Juri Jeong, Jaehwan Kim, Suyeon Jeon, Zee Yong Park, Kang-Jin Jung, Kwangsung Park, Chunghee Cho   +10 more
doaj   +1 more source

Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State

Membranes, 2022
A disintegrin and metalloproteinase 15 (ADAM15) is a member of the ADAM family of sheddases. Its genetic ablation in mice suggests that ADAM15 plays an important role in a wide variety of biological functions, including cartilage homeostasis ...
Chun-Yao Yang, Simone Bonelli, Matteo Calligaris, Anna Paola Carreca, Stephan A. Müller, Stefan F. Lichtenthaler, Linda Troeberg, Simone D. Scilabra   +7 more
doaj   +1 more source

Expression of ADAM‐9 mRNA and protein in human breast cancer [PDF]

International Journal of Cancer, 2003
AbstractThe ADAMs (a disintegrin and metalloprotease) are membrane proteins containing both protease and adhesion domains and thus may be potentially important in cancer invasion and metastasis. The aim of our study was to investigate the distribution and potential clinical significance of ADAM‐9 in breast cancer.
O'Shea C, McKie N, Buggy Y, Duggan C, Hill ADK, McDermotti E, O'Higgins N, Duffy MJ   +7 more
openaire   +3 more sources

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase [PDF]

Journal of Biological Chemistry, 2009
ADAM10 is involved in the proteolytic processing and shedding of proteins such as the amyloid precursor protein (APP), cadherins, and the Notch receptors, thereby initiating the regulated intramembrane proteolysis (RIP) of these proteins. Here, we demonstrate that the sheddase ADAM10 is also subject to RIP.
Tousseyn, T, Thathiah, A, Jorissen, E, Raemaekers, T, Konietzko, U, Reiss, K, Maes, E, Snellinx, A, Serneels, L, Nyabi, O, Annaert, W, Saftig, P, Hartmann, D, De Strooper, B   +13 more
openaire   +2 more sources

Identification of ADAM 31: A Protein Expressed in Leydig Cells and Specialized Epithelia* [PDF]

Endocrinology, 2000
A family of proteins containing a disintegrin and metalloproteinase domain (ADAMs) has been identified recently. Here, we report the identification of a novel member of the ADAM protein family from mouse. This protein is designated ADAM 31. The complementary DNA sequence of ADAM 31 predicts a transmembrane protein with metalloproteinase, disintegrin ...
L, Liu, J W, Smith
openaire   +2 more sources

Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus

Frontiers in Cellular Neuroscience, 2015
Brain is continuously altered in response to experience and environmental changes. One of the underlying mechanisms is synaptic plasticity, which is manifested by modification of synapse structure and function.
Grzegorz eWiera, Grzegorz eWiera, Jerzy W Mozrzymas, Jerzy W Mozrzymas   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes

Cardiovascular Diabetology, 2007
Aims Type 2 diabetes is characterised by increased plasma concentrations of pro-inflammatory cytokines [such as tumour necrosis factor – alpha; TNF-α] and soluble forms of adhesion molecules involved in leukocyte – endothelial interactions.
Dozio Nicoletta, Hughes David A, Worley Joanna R, Gavrilovic Jelena, Sampson Mike J   +4 more
doaj   +1 more source

Polymeric ADAM Protein Mimics Interrogate Mammalian Sperm–Egg Binding [PDF]

ChemBioChem, 2009
AbstractROMPing with the ADAMs family: The sperm‐surface display of egg adhesion proteins was investigated using multivalent polymer sperm mimics. Ruthenium‐catalyzed ring opening metathesis polymerization (ROMP) was used to synthesize heterovalent polymers.magnified imageThe sperm proteins ADAM2 and ADAM3, members of the ADAM family of proteins, have ...
Younjoo, Lee, Nicole S, Sampson
openaire   +2 more sources