Results 181 to 190 of about 182,768 (228)

ADAM family proteins in the immune system

Immunology Today, 1999
CD156 is a member of a family proteins characterized by a disintegrin and a metalloprotease domain (ADAM). These molecules are phylogenically conserved but have individual roles in a variety of cells. Here, Shunsuke Yamamoto and colleagues discuss data suggesting that ADAM family proteins have important roles in the immune system.
S, Yamamoto, Y, Higuchi, K, Yoshiyama, E, Shimizu, M, Kataoka, N, Hijiya, K, Matsuura   +6 more
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Shedding of membrane proteins by ADAM family proteases

Essays in Biochemistry, 2002
Many membrane-bound proteins undergo proteolytic release from the membrane, a process known as 'shedding'. Some of the processing events are carried out by enzymes of the ADAM (a disintegrin and metalloproteinase) family, which are also membrane bound.
Marcia L, Moss, Millard H, Lambert
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Altered cell-matrix associated ADAM proteins in Alzheimer disease

Journal of Neuroscience Research, 2000
Alterations in cell-matrix 'contact' are often related to a disruption of cell cycle regulation and, as such, occur variously in neoplasia. Given the recent findings showing cell cycle alterations in Alzheimer disease, we undertook a study of ADAM-1 and 2 (A Disintegrin And Metalloprotease), developmentally-regulated, integrin-binding, membrane-bound ...
Smith, MA, Takeda, A, Petersen, RB, Pirim, I, Gerst, JL, McShea, A, Harris, PLR, Siedlak, SL, Raina, AK   +8 more
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Sexual Selection and the Molecular Evolution of ADAM Proteins

Journal of Molecular Evolution, 2010
Rapid evolution has been identified for many reproductive genes and recent studies have combined phylogenetic tests and information on species mating systems to test sexual selection. Here we examined the molecular evolution of the ADAM gene family, a diverse group of 35 proteins capable of adhesion to and cleavage of other proteins, using sequence ...
Scott, Finn, Alberto, Civetta
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Structure-Activity Relationship Studies on ADAM Protein-Integrin Interactions

Cardiovascular & Hematological Agents in Medicinal Chemistry, 2007
The ADAM (a disintegrin and metalloprotease) family of proteins possess multi-domain structures composed of a signal peptide, a prodomain, a metalloprotease domain, a disintegrin-like domain, a cysteine rich domain, an epidermal growth factor-like domain, a transmembrane domain and cytoplasmic tail.
X, Lu, D, Lu, M F, Scully, V V, Kakkar
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ADAMs family members as amyloid precursor protein α‐secretases

Journal of Neuroscience Research, 2003
AbstractIn the non‐amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is cleaved within the amyloid‐β domain by α‐secretase precluding deposition of intact amyloid‐β peptide. The large ectodomain released from the cell surface by the action of α‐secretase has several neuroprotective properties.
Allinson, Tobias M. J., Parkin, Edward T., Turner, Anthony J., Hooper, Nigel M.   +3 more
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ADAM proteins in the brain

Journal of Clinical Neuroscience, 2004
ADAM proteins are a family of metalloproteinases with a disintegrin domain. They have proteolytic as well as adhesive functions and can be involved in cell fusion events. Some ADAM proteins are expressed in a highly tissue restricted fashion, whereas others are expressed quite ubiquitously. In the brain, ADAM proteins have a role in neural development,
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ADAM proteins, their ligands, and clinical implications

Neurology, 2012
AD= : Alzheimer disease; ADAM= : A disintegrin and metalloproteinase; ADEAF= : autosomal dominant partial epilepsy with auditory features; ADTLE= : autosomal dominant familial temporal lobe epilepsy; APP= : amyloid precursor protein; EPTP= : epitempin; Kv= : voltage-gated potassium; LGI= : leucine-rich, glioma inactivated; LRR= :
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The ADAM gene family: surface proteins with adhesion and protease activity

Trends in Genetics, 2000
An ADAM is a transmembrane protein that contains a disintegrin and metalloprotease domain and, therefore, it potentially has both cell adhesion and protease activities. Currently, the ADAM gene family has 29 members, although the function of most ADAM gene products is unknown.
P, Primakoff, D G, Myles
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Endothelial metalloprotease-disintegrin protein (ADAM) is implicated in angiogenesis in vitro

Angiogenesis, 1998
Recently two metalloproteinase, disintegrin, cysteine proteins (MDCs), also called ADAMs were identified on endothelial cells. However the role of these ADAMs are not defined on these cells. In order to elucidate whether ADAMs associated with endothelial cells could be involved in angiogenesis, we have tested the effect of an inhibitor of ADAM (GL ...
V, Trochon, H, Li, M, Vasse, F, Frankenne, A, Thomaidis, J, Soria, H, Lu, C, Gardner, C, Soria   +8 more
openaire   +2 more sources